Targeting metabolism to regulate immune responses in autoimmunity and cancer von Patel, Chirag H., Leone, Robert D., Horton, Maureen R., Powell, Jonathan D.

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Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion von Leone, Robert D, Zhao, Liang, Englert, Judson M, Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Arwood, Matthew L, Bettencourt, Ian A, Patel, Chirag H, Wen, Jiayu, Tam, Ada, Blosser, Richard L, Prchalova, Eva, Alt, Jesse, Rais, Rana, Slusher, Barbara S, Powell, Jonathan D

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Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy von Augustin, Ryan C., Leone, Robert D., Naing, Aung, Fong, Lawrence, Bao, Riyue, Luke, Jason J.

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Metabolism of immune cells in cancer von Leone, Robert D., Powell, Jonathan D.

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A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy von Leone, Robert D, Lo, Ying-Chun, Powell, Jonathan D

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Targeting adenosine for cancer immunotherapy von Leone, Robert D, Emens, Leisha A

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Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy von Leone, Robert D., Horton, Maureen R., Powell, Jonathan D.

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Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis von Parveen, Sadiya, Shen, Jessica, Lun, Shichun, Zhao, Liang, Alt, Jesse, Koleske, Benjamin, Leone, Robert D., Rais, Rana, Powell, Jonathan D., Murphy, John R., Slusher, Barbara S., Bishai, William R.

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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells von Oh, Min-Hee, Sun, Im-Hong, Zhao, Liang, Leone, Robert D, Sun, Im-Meng, Xu, Wei, Collins, Samuel L, Tam, Ada J, Blosser, Richard L, Patel, Chirag H, Englert, Judson M, Arwood, Matthew L, Wen, Jiayu, Chan-Li, Yee, Tenora, Lukáš, Majer, Pavel, Rais, Rana, Slusher, Barbara S, Horton, Maureen R, Powell, Jonathan D

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Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine can... von Leone, Robert D., Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Wen, Jiayu, Englert, Judson, Powell, Jonathan D.

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Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy von Leone, Robert D, Powell, Jonathan D

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Autophagy: a targetable linchpin of cancer cell metabolism von Leone, Robert D, Amaravadi, Ravi K

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SIKs Regulate HDAC7 Stabilization and Cytokine Recall in Late-Stage T Cell Effector Differentiation von Helms, Rachel S, Marin-Gonzalez, Alberto, Patel, Chirag H, Sun, Im-Hong, Wen, Jiayu, Leone, Robert D, Duvall, Bridget, Gao, Run-Duo, Ha, Taekjip, Tsukamoto, Takashi, Slusher, Barbara S, Pomerantz, Joel L, Powell, Jonathan D

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Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation von Dalton, W Brian, Helmenstine, Eric, Walsh, Noel, Gondek, Lukasz P, Kelkar, Dhanashree S, Read, Abigail, Natrajan, Rachael, Christenson, Eric S, Roman, Barbara, Das, Samarjit, Zhao, Liang, Leone, Robert D, Shinn, Daniel, Groginski, Taylor, Madugundu, Anil K, Patil, Arun, Zabransky, Daniel J, Medford, Arielle, Lee, Justin, Cole, Alex J, Rosen, Marc, Thakar, Maya, Ambinder, Alexander, Donaldson, Joshua, DeZern, Amy E, Cravero, Karen, Chu, David, Madero-Marroquin, Rafael, Pandey, Akhilesh, Hurley, Paula J, Lauring, Josh, Park, Ben Ho

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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug von Rais, Rana, Lemberg, Kathryn M, Tenora, Lukáš, Arwood, Matthew L, Pal, Arindom, Alt, Jesse, Wu, Ying, Lam, Jenny, Aguilar, Joanna Marie H, Zhao, Liang, Peters, Diane E, Tallon, Carolyn, Pandey, Rajeev, Thomas, Ajit G, Dash, Ranjeet P, Seiwert, Tanguy, Majer, Pavel, Leone, Robert D, Powell, Jonathan D, Slusher, Barbara S

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Abstract 4364: Adenosine A2a receptor blockade as a means of enhancing immune checkpoint inhibition and adoptive T-cell therapy von Leone, Robert D., Englert, Judson M., Cheng, Chih-Hsien, Wen, Jiayu, Oh, Min-Hee, Sun, Im-Hong, Patel, Chirag, Bettencourt, Ian A., Powell, Jonathan D.

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Interrogation of T Cell-Enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism von Harbison, R Alex, Pandey, Rajeev, Considine, Michael, Leone, Robert D, Murray-Stewart, Tracy, Erbe, Rossin, Mandal, Raj, Burns, Mark, Casero, Jr, Robert A, Seiwert, Tanguy, Fakhry, Carole, Pardoll, Drew, Fertig, Elana, Powell, Jonathan D

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Introduction of a Novel HRP Substrate-Nanogold Probe for Signal Amplification in Immunocytochemistry von Mayer, Gaetan, Leone, Robert D, Hainfeld, James F, Bendayan, Moise

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Enhanced T cell effector function upon differentiation of CD8+ and CD4+ T cells in the presence of BioE-1197 through potential off target ARK family inhibition von Helms, Rachel Shannon, Patel, Chirag H., Leone, Robert D., Duvall, Bridget, Gao, Run-Duo, Tsukamoto, Takashi, Slusher, Barbara S., Pomerantz, Joel L., Powell, Jonathan D

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Abstract 573: Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083 von Leone, Robert D., Englert, Judson M., Oh, Min-Hee, Cheng, Chih-Hsien, Rais, Rana, Slusher, Barbara, Powell, Jonathan D.

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