Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach von Steeneck, Christoph, Gege, Christian, Kinzel, Olaf, Albers, Michael, Kleymann, Gerald, Schlüter, Thomas, Schulz, Andreas, Xue, Xiaohua, Cummings, Maxwell D., Fourie, Anne M., Leonard, Kristi A., Scott, Brian, Edwards, James P., Hoffmann, Thomas, Goldberg, Steven D.

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease von Leonard, Kristi A, Madge, Lisa A, Krawczuk, Paul J, Wang, Aihua, Kreutter, Kevin D, Bacani, Genesis M, Chai, Wenying, Smith, Russell C, Tichenor, Mark S, Harris, Michael C, Malaviya, Ravi, Seierstad, Mark, Johnson, Marguerite E, Venable, Jennifer D, Kim, Suzie, Hirst, Gavin C, Mathur, Ashok S, Rao, Tadimeti S, Edwards, James P, Rizzolio, Michele C, Koudriakova, Tatiana

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity von Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P

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Design, Synthesis, and Biological Evaluation of Novel Potent and Selective αvβ3/αvβ5 Integrin Dual Inhibitors with Improved Bioavailability. Selection of the Molecular Core von Marugán, Juan José, Manthey, Carl, Anaclerio, Beth, Lafrance, Lou, Lu, Tianbao, Markotan, Tom, Leonard, Kristi A, Crysler, Carl, Eisennagel, Stephen, Dasgupta, Malini, Tomczuk, Bruce

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A Transient N−O-Linked Pauson−Khand Strategy for the Synthesis of the Deschloro Carbocyclic Core of the Palau'amines and Styloguanidines von Koenig, Stefan G, Miller, Stefan M, Leonard, Kristi A, Löwe, Ralf S, Chen, Betty C, Austin, David J

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Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation von Scannevin, Robert H., Alexander, Richard, Haarlander, Tara Mezzasalma, Burke, Sharon L., Singer, Monica, Huo, Cuifen, Zhang, Yue-Mei, Maguire, Diane, Spurlino, John, Deckman, Ingrid, Carroll, Karen I., Lewandowski, Frank, Devine, Eric, Dzordzorme, Keli, Tounge, Brett, Milligan, Cindy, Bayoumy, Shariff, Williams, Robyn, Schalk-Hihi, Celine, Leonard, Kristi, Jackson, Paul, Todd, Matthew, Kuo, Lawrence C., Rhodes, Kenneth J.

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2,4,6-Triarylchalcogenopyrylium Dyes Related in Structure to the Antitumor Agent AA1 as in Vitro Sensitizers for the Photodynamic Therapy of Cancer von Leonard, Kristi A, Nelen, Marina I, Anderson, Linda T, Gibson, Scott L, Hilf, Russell, Detty, Michael R

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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis von Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria-Babi, Luis, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L., Fourie, Anne M.

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A Selenopyrylium Photosensitizer for Photodynamic Therapy Related in Structure to the Antitumor Agent AA1 with Potent in Vivo Activity and No Long-Term Skin Photosensitization von Leonard, Kristi A, Hall, Jonathan P, Nelen, Marina I, Davies, Sherry R, Gollnick, Sandra O, Camacho, Sue, Oseroff, Allan R, Gibson, Scott L, Hilf, Russell, Detty, Michael R

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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt von Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.

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Synthesis and Evaluation of Chalcogenopyrylium Dyes as Potential Sensitizers for the Photodynamic Therapy of Cancer von Leonard, Kristi A, Nelen, Marina I, Simard, Todd P, Davies, Sherry R, Gollnick, Sandra O, Oseroff, Allan R, Gibson, Scott L, Hilf, Russell, Chen, Lan Bo, Detty, Michael R

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Identification and biological evaluation of thiazole-based inverse agonists of RORγt von Gege, Christian, Cummings, Maxwell D., Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Nelen, Marina I., Milligan, Cindy, Spurlino, John, Xue, Xiaohua, Leonard, Kristi, Edwards, James P., Fourie, Anne, Goldberg, Steven D., Hoffmann, Thomas

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Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt von Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

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6-Substituted quinolines as RORγt inverse agonists von Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

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3-Substituted Quinolines as RORγt Inverse Agonists von Tanis, Virginia M., Venkatesan, Hariharan, Cummings, Maxwell D., Albers, Michael, Kent Barbay, J., Herman, Krystal, Kummer, David A., Milligan, Cynthia, Nelen, Marina I., Nishimura, Rachel, Schlueter, Thomas, Scott, Brian, Spurlino, John, Wolin, Ronald, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

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Synthesis of 3,4-substituted cyclopentenones via an intramolecular Pauson–Khand reaction of NO linked enynes von Koenig, Stefan G, Leonard, Kristi A, Löwe, Ralf S, Austin, David J

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Chalcogen(IV)−Chalcogen(II) Redox Cycles. 1. Halogenation of Organic Substrates with Dihaloselenium(IV) and -tellurium(IV) Derivatives. Dehalogenation of Vicinal Dibromides with Di... von Leonard, Kristi A, Zhou, Feng, Detty, Michael R

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Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis von Xue, Xiaohua, Soroosh, Pejman, De Leon-Tabaldo, Aimee, Luna-Roman, Rosa, Sablad, Marciano, Rozenkrants, Natasha, Yu, Jingxue, Castro, Glenda, Banie, Homayon, Fung-Leung, Wai-Ping, Santamaria Babí, Luis F, Schlueter, Thomas, Albers, Michael, Leonard, Kristi, Budelsky, Alison L, Fourie, Anne M

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Design and Characterization of Optimized Adenosine A 2A /A 1 Receptor Antagonists for the Treatment of Parkinson's Disease von Shook, Brian C., Rassnick, Stefanie, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Powell, Mark T., Leonard, Kristi, Alford, Vernon, Scannevin, Robert H., Carroll, Karen, Lampron, Lisa, Westover, Lori, Lim, Heng-Keang, Russell, Ronald, Branum, Shawn, Wells, Kenneth M., Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A., Rhodes, Kenneth, Jackson, Paul F.

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Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists von Shook, Brian C., Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Leonard, Kristi, Alford, Vernon, Powell, Mark T., Rassnick, Stefanie, Scannevin, Robert H., Carroll, Karen, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Lampron, Lisa, Westover, Lori, Rhodes, Kenneth, Jackson, Paul F.

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