Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development von Dang, Lenny, Su, Shin-San Michael

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Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase von Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage von Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya

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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation von Wang, Fang, Travins, Jeremy, DeLaBarre, Byron, Penard-Lacronique, Virginie, Schalm, Stefanie, Hansen, Erica, Straley, Kimberly, Kernytsky, Andrew, Liu, Wei, Gliser, Camelia, Yang, Hua, Gross, Stefan, Artin, Erin, Saada, Veronique, Mylonas, Elena, Quivoron, Cyril, Popovici-Muller, Janeta, Saunders, Jeffrey O., Salituro, Francesco G., Yan, Shunqi, Murray, Stuart, Wei, Wentao, Gao, Yi, Dang, Lenny, Dorsch, Marion, Agresta, Sam, Schenkein, David P., Biller, Scott A., Su, Shinsan M., de Botton, Stephane, Yen, Katharine E.

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

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Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma von Konteatis, Zenon, Artin, Erin, Nicolay, Brandon, Straley, Kimberly, Padyana, Anil K, Jin, Lei, Chen, Yue, Narayaraswamy, Rohini, Tong, Shuilong, Wang, Feng, Zhou, Ding, Cui, Dawei, Cai, Zhenwei, Luo, Zhiyong, Fang, Cheng, Tang, Huachun, Lv, Xiaobing, Nagaraja, Raj, Yang, Hua, Su, Shin-San M, Sui, Zhihua, Dang, Lenny, Yen, Katharine, Popovici-Muller, Janeta, Codega, Paolo, Campos, Carl, Mellinghoff, Ingo K, Biller, Scott A

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Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice von Mattè, Alessandro, Kosinski, Penelope A, Federti, Enrica, Dang, Lenny, Recchiuti, Antonio, Russo, Roberta, Siciliano, Angela, Riccardi, Veronica, Janin, Anne, Mucci, Matteo, Leboeuf, Christophe, Iolascon, Achille, Brugnara, Carlo, De Franceschi, Lucia

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes von Rab, Minke A E, Van Oirschot, Brigitte A, Kosinski, Penelope A, Hixon, Jeffrey, Johnson, Kendall, Chubukov, Victor, Dang, Lenny, Pasterkamp, Gerard, Van Straaten, Stephanie, Van Solinge, Wouter W, Van Beers, Eduard J, Kung, Charles, Van Wijk, Richard

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Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 von Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton

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P1485: PKM AND PKR EXPRESSION DURING HEMATOPOIESIS AND ERYTHROPOIESIS von Tsai, Erin, Rivadeneyra, Leonardo, Yilmaz, Saliha, Dang, Lenny, Wind‐Rotolo, Megan

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Small Molecule Inhibitors of IκB Kinase Are Selectively Toxic for Subgroups of Diffuse Large B-Cell Lymphoma Defined by Gene Expression Profiling von LAM, Lloyd T, DAVIS, R. Eric, STAUDT, Louis M, PIERCE, Jackie, HEPPERLE, Michael, YAJUN XU, HOTTELET, Maria, YUHUA NONG, DANYI WEN, ADAMS, Julian, DANG, Lenny

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Interleukin 6, a Nuclear Factor-κB Target, Predicts Resistance to Docetaxel in Hormone-Independent Prostate Cancer and Nuclear Factor-κB Inhibition by PS-1145 Enhances Docetaxel An... von DOMINGO-DOMENECH, Josep, OLIVA, Cristina, ROLFE, Mark, ROSS, Jeffrey S, GASCON, Pere, ALBANELL, Joan, MELLADO, Begona, ROVIRA, Ana, CODONY-SERVAT, Jordi, BOSCH, Marta, FILELLA, Xavier, MONTAGUT, Clara, TAPIA, Marian, CAMPAS, Clara, DANG, Lenny

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MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo von HIDESHIMA, Teru, NERI, Paola, MUNSHI, Nikhil, RICHARDSON, Paul, SCHENKEIN, David, ANDERSON, Kenneth C, TASSONE, Pierfranchesco, YASUI, Hiroshi, ISHITSUKA, Kenji, RAJE, Noopur, CHAUHAN, Dharminder, PODAR, Klaus, MITSIADES, Constantine, DANG, Lenny

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Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen von Lam, Lloyd T, Davis, R. Eric, Ngo, Vu N, Lenz, Georg, Wright, George, Xu, Weihong, Zhao, Hong, Yu, Xin, Dang, Lenny, Staudt, Louis M

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P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES von Wilde, Jonathan, Ruiter, Titine, Oirschot, Brigitte, Jans, Judith, Dang, Lenny, Wind‐Rotolo, Megan, Solinge, Wouter, Rhenen, Anna, Van Wijk, Richard, Rab, Minke

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Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis von Matte, Alessandro, Wilson, Anand B., Gevi, Federica, Federti, Enrica, Recchiuti, Antonio, Ferri, Giulia, Brunati, Anna Maria, Pagano, Mario Angelo, Russo, Roberta, Leboeuf, Christophe, Janin, Anne, Timperio, Anna Maria, Iolascon, Achille, Gremese, Elisa, Dang, Lenny, Mohandas, Narla, Brugnara, Carlo, De Franceschi, Lucia

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IDH mutations in glioma and acute myeloid leukemia von Dang, Lenny, Jin, Shengfang, Su, Shinsan M

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Protein engineering: A biocatalyst inspired by cancer von Dang, Lenny

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A biocatalyst inspired by cancer von Dang, Lenny

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