Tumor Suppressor Protein Pdcd4 Inhibits Translation of p53 mRNA von Wedeken, Lena, Singh, Priyanka, Klempnauer, Karl-Heinz

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Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models von Roohani, Siyer, Loskutov, Jürgen, Heufelder, Jens, Ehret, Felix, Wedeken, Lena, Regenbrecht, Manuela, Sauer, Rica, Zips, Daniel, Denker, Andrea, Joussen, Antonia M, Regenbrecht, Christian R A, Kaul, David

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Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models von Dahlmann, Mathias, Gambara, Guido, Brzezicha, Bernadette, Popp, Oliver, Pachmayr, Eva, Wedeken, Lena, Pflaume, Alina, Mokritzkij, Margarita, Gül-Klein, Safak, Brandl, Andreas, Schweiger-Eisbacher, Caroline, Mertins, Philipp, Hoffmann, Jens, Keilholz, Ulrich, Walther, Wolfgang, Regenbrecht, Christian, Rau, Beate, Stein, Ulrike

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Functional Precision Medicine Successfully Guides Therapeutic Regimen of ‘Cancer of Unknown Primary’ Later Classified as Triple-Negative Breast Cancer: A Case Report von Ruhe, Larissa, Heibl, Sonja, Czompo, Manfred, Haybaeck, Johannes, Loskutov, Jürgen, Regenbrecht, Manuela Johanna, Thaler, Josef, Wedeken, Lena, Regenbrecht, Christian René Alexander

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Context Matters—Why We Need to Change From a One Size Fits all Approach to Made-to-Measure Therapies for Individual Patients With Pancreatic Cancer von Sankarasubramanian, Sushmitha, Pfohl, Ulrike, Regenbrecht, Christian R. A., Reinhard, Christoph, Wedeken, Lena

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Precision Oncology Beyond Genomics: The Future Is Here—It Is Just Not Evenly Distributed von Pfohl, Ulrike, Pflaume, Alina, Regenbrecht, Manuela, Finkler, Sabine, Graf Adelmann, Quirin, Reinhard, Christoph, Regenbrecht, Christian, Wedeken, Lena

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A RAS-independent biomarker panel pedicts response to MEK-inhibitors in colorectal cancer von Pfohl, Ulrike, Loskutov, Jürgen, Bashir, Sanum, Kühn, Ralf, Templin, Markus, Mamlouk, Soulafa, Belanov, Sergei, Vetter, Marcus, Reinhard, Christoph, Wedeken, Lena, Regenbrecht, Christian RA

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Abstract 190: Personalized identification of cancer treatments in real-time: TumOC - a tumor organoid-on-chip platform for online cell vitality measurements von Flechner, Marie, Loskutov, Juergen, Nadolny, Madeleine, Pfohl, Ulrike, Regenbrecht, Christian R., Uhlig, Katja, Wedeken, Lena

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Adult Murine Pancreatic Progenitors Require Epidermal Growth Factor and Nicotinamide for Self-Renewal and Differentiation in a Serum- and Conditioned Medium-Free Culture von Wedeken, Lena, Luo, Angela, Tremblay, Jacob R., Rawson, Jeffrey, Jin, Liang, Gao, Dan, Quijano, Janine, Ku, Hsun Teresa

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Personalized Organoid-Based Treatments in Older Patients with Cancer: A Registry Study in Progress von Pirmin Häuptle, Kirsten Mertz, Michèle Voegeli, Robert Rosenberg, Emanuel Burri, Svetozar Subotic, Anna Romanens, Anne Leuppi-Taegtmeyer, Christian Regenbrecht, Lena Wedeken, Marcus Vetter

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Abstract 6209: TumOC: A tumor organoid-on-chip platform for real-time cell vitality measurements von Flechner, Marie, Loskutov, Juergen, Pfohl, Ulrike, Osman, Katja, Regenbrecht, Christian R., Uhlig, Katja, Wedeken, Lena

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Precision Oncology Beyond Genomics: The Future Is Here-It Is Just Not Evently Distributed von Pfohl, Ulrike, Pflaume, Alina, Regenbrecht, Manuela, Finkler, Sabine, Graf Adelmann, Quirin, Reinhard, Christoph, Regenbrecht, Christian R A, Wedeken, Lena

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Methylcellulose colony assay and single-cell micro-manipulation reveal progenitor-like cells in adult human pancreatic ducts von Quijano, Janine C., Wedeken, Lena, Ortiz, Jose A., Zook, Heather N., LeBon, Jeanne M., Luo, Angela, Rawson, Jeffrey, Tremblay, Jacob R., Mares, Jacob M., Lopez, Kassandra, Chen, Min-Hsuan, Jou, Kevin, Mendez-Dorantes, Carlos, Al-Abdullah, Ismail H., Thurmond, Debbie C., Kandeel, Fouad, Riggs, Arthur D., Ku, Hsun Teresa

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A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal Cancer von Pfohl, Ulrike, Loskutov, Jürgen, Bashir, Sanum, Kühn, Ralf, Herter, Patrick, Templin, Markus, Mamlouk, Soulafa, Belanov, Sergei, Linnebacher, Michael, Bürtin, Florian, Vetter, Marcus, Reinhard, Christoph, Wedeken, Lena, Regenbrecht, Christian R. A.

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Abstract 187: Let’s get physiological! Impact of media conditions on drug response to targeted therapies in CRC organoids von Loskutov, Jürgen, Erdmann, Gerrit, Arndt, Anja, Adelmann, Quirin Graf, Dudys, Przemyslaw, Flechner, Marie, Nadolny, Madeleine, Osman, Katja, Pfohl, Ulrike, Reinhard, Christoph, Templin, Markus, Uhlig, Katja, Wedeken, Lena, Regenbrecht, Christian

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Abstract 6223: PD3D®models: New age in cancer research and clinical diagnostics von Pflaume, Alina, Exner, Samantha, Herrera-Glomm, Katja, Loskutov, Jürgen, Pfohl, Ulrike, Regenbrecht, Manuela, Sankarasubramanian, Sushmitha, Wedeken, Lena, Finkler, Sabine, Ruhe, Larissa, Adelmann, Quirin Graf, Reinhard, Christoph, Stroebel, Philipp, Regenbrecht, Christian R.

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Cells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas von Jin, Liang, Gao, Dan, Feng, Tao, Tremblay, Jacob R., Ghazalli, Nadiah, Luo, Angela, Rawson, Jeffrey, Quijano, Janine C., Chai, Jing, Wedeken, Lena, Hsu, Jasper, LeBon, Jeanne, Walker, Stephanie, Shih, Hung-Ping, Mahdavi, Alborz, Tirrell, David A., Riggs, Arthur D., Ku, H. Teresa

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In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas von Tremblay, Jacob R., LeBon, Jeanne M., Luo, Angela, Quijano, Janine C., Wedeken, Lena, Jou, Kevin, Riggs, Arthur D., Tirrell, David A., Ku, H. Teresa

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In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas von Tremblay, Jacob R, LeBon, Jeanne M, Luo, Angela, Quijano, Janine C, Wedeken, Lena, Jou, Kevin, Riggs, Arthur D, Tirrell, David A, Ku, H Teresa

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Expression level and agonist-binding affect the turnover, ubiquitination and complex formation of peroxisome proliferator activated receptor β von Rieck, Markus, Wedeken, Lena, Müller-Brüsselbach, Sabine, Meissner, Wolfgang, Müller, Rolf

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