Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase von Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi

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Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes von LAMORTE, Louie, TITOLO, Steve, AIKEN, Christopher, SUNDQUIST, Wesley I, MASON, Stephen W, LEMKE, Christopher T, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, SHAH, Vaibhav B, VON SCHWEDLER, Uta K, LANGELIER, Charles, BANIK, Soma S. R

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Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein von LEMKE, Christopher T, TITOLO, Steve, GAGNON, Alexandre, KAWAI, Stephen H, RANCOURT, Jean, TREMBLAY, Martin, YOAKIM, Christiane, SIMONEAU, Bruno, ARCHAMBAULT, Jacques, SUNDQUIST, Wesley I, MASON, Stephen W, VON SCHWEDLER, Uta, GOUDREAU, Nathalie, MERCIER, Jean-François, WARDROP, Elizabeth, FAUCHER, Anne-Marie, COULOMBE, Rene, BANIK, Soma S. R, FADER, Lee

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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly von Fader, Lee D., Bethell, Richard, Bonneau, Pierre, Bös, Michael, Bousquet, Yves, Cordingley, Michael G., Coulombe, René, Deroy, Patrick, Faucher, Anne-Marie, Gagnon, Alexandre, Goudreau, Nathalie, Grand-Maître, Chantal, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lacoste, Jean-Eric, Landry, Serge, Lemke, Christopher T., Malenfant, Eric, Mason, Stephen, Morin, Sébastien, O’Meara, Jeff, Simoneau, Bruno, Titolo, Steve, Yoakim, Christiane

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Structure of the Antibiotic Resistance Factor Spectinomycin Phosphotransferase from Legionella pneumophila von Fong, Desiree H., Lemke, Christopher T., Hwang, Jiyoung, Xiong, Bing, Berghuis, Albert M.

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Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole sca... von Tremblay, Martin, Bonneau, Pierre, Bousquet, Yves, DeRoy, Patrick, Duan, Jianmin, Duplessis, Martin, Gagnon, Alexandre, Garneau, Michel, Goudreau, Nathalie, Guse, Ingrid, Hucke, Oliver, Kawai, Stephen H., Lemke, Christopher T., Mason, Stephen W., Simoneau, Bruno, Surprenant, Simon, Titolo, Steve, Yoakim, Christiane

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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers von Ito, Takahiro, Young, Michael J., Li, Ruitong, Jain, Sidharth, Wernitznig, Andreas, Krill-Burger, John M., Lemke, Christopher T., Monducci, Davide, Rodriguez, Diego J., Chang, Liang, Dutta, Sanjukta, Pal, Debjani, Paolella, Brenton R., Rothberg, Michael V., Root, David E., Johannessen, Cory M., Parida, Laxmi, Getz, Gad, Vazquez, Francisca, Doench, John G., Zamanighomi, Mahdi, Sellers, William R.

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Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex von Kwon, Jason J., Hajian, Behnoush, Bian, Yuemin, Young, Lucy C., Amor, Alvaro J., Fuller, James R., Fraley, Cara V., Sykes, Abbey M., So, Jonathan, Pan, Joshua, Baker, Laura, Lee, Sun Joo, Wheeler, Douglas B., Mayhew, David L., Persky, Nicole S., Yang, Xiaoping, Root, David E., Barsotti, Anthony M., Stamford, Andrew W., Perry, Charles K., Burgin, Alex, McCormick, Frank, Lemke, Christopher T., Hahn, William C., Aguirre, Andrew J.

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Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069 von Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Ligand Bioactive Conformation Plays a Critical Role in the Design of Drugs That Target the Hepatitis C Virus NS3 Protease von LaPlante, Steven R., Nar, Herbert, Lemke, Christopher T., Jakalian, Araz, Aubry, Norman, Kawai, Stephen H.

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation von Babbe, Holger, Sundberg, Thomas B, Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Chai, Wenying, Chang, Leon, Chung, De Michael, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T, Mak, Puiying A, Mathur, Ashok, Mercado-Marin, Eduardo V, Metkar, Shailesh, Raymond, Donald D, Rives, Marie-Laure, Rizzolio, Michele, Shaffer, Paul L, Smith, Russell, Smith, Jacqueline, Steele, Ruth, Steffens, Helena, Suarez, Javier, Tian, Gaochao, Majewski, Nathan, Volak, Laurie P, Wei, Jianmei, Desai, Prerak T, Ong, Luvena L, Koudriakova, Tatiana, Goldberg, Steven D, Hirst, Gavin, Kaushik, Virendar K, Ort, Tatiana, Seth, Nilufer, Graham, Daniel B, Plevy, Scott, Venable, Jennifer D, Xavier, Ramnik J, Towne, Jennifer E

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Correction to “Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069” von Orsi, Douglas L., Pook, Elisabeth, Bräuer, Nico, Friberg, Anders, Lienau, Philip, Lemke, Christopher T., Stellfeld, Timo, Brüggemeier, Ulf, Pütter, Vera, Meyer, Hanna, Baco, Maria, Tang, Stephanie, Cherniack, Andrew D., Westlake, Lindsay, Bender, Samantha A., Kocak, Mustafa, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists von Orsi, Douglas L., Ferrara, Steven J., Siegel, Stephan, Friberg, Anders, Bouché, Léa, Pook, Elisabeth, Lienau, Philip, Bluck, Joseph P., Lemke, Christopher T., Akcay, Gizem, Stellfeld, Timo, Meyer, Hanna, Pütter, Vera, Holton, Simon J., Korr, Daniel, Jerchel-Furau, Isabel, Pantelidou, Constantia, Strathdee, Craig A., Meyerson, Matthew, Eis, Knut, Goldstein, Jonathan T.

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Multimodal small-molecule screening for human prion protein binders von Reidenbach, Andrew G., Mesleh, Michael F., Casalena, Dominick, Vallabh, Sonia M., Dahlin, Jayme L., Leed, Alison J., Chan, Alix I., Usanov, Dmitry L., Yehl, Jenna B., Lemke, Christopher T., Campbell, Arthur J., Shah, Rishi N., Shrestha, Om K., Sacher, Joshua R., Rangel, Victor L., Moroco, Jamie A., Sathappa, Murugappan, Nonato, Maria Cristina, Nguyen, Kong T., Wright, S. Kirk, Liu, David R., Wagner, Florence F., Kaushik, Virendar K., Auld, Douglas S., Schreiber, Stuart L., Minikel, Eric Vallabh

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Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335 von Lemke, Christopher T., Goudreau, Nathalie, Zhao, Songping, Hucke, Oliver, Thibeault, Diane, Llinàs-Brunet, Montse, White, Peter W.

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A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization von Lemke, Christopher T., Titolo, Steve, Goudreau, Nathalie, Faucher, Anne-Marie, Mason, Stephen W., Bonneau, Pierre

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BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models von Rauh, Ulrike, Wei, Guo, Serrano-Wu, Michael, Kosmidis, Georgios, Kaulfuss, Stefan, Siegel, Franziska, Thede, Kai, McFarland, James, Lemke, Christopher T., Werbeck, Nicolas, Nowak-Reppel, Katrin, Pilari, Sabine, Menz, Stephan, Ocker, Matthias, Zhang, Weiqun, Davis, Kyle, Poncet-Montange, Guillaume, Roth, Jennifer, Daniels, Douglas, Kaushik, Virendar K., Hubbard, Brian, Ziegelbauer, Karl, Golub, Todd R.

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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor von Garvie, Colin W., Fraley, Cara V., Elowe, Nadine H., Culyba, Elizabeth K., Lemke, Christopher T., Hubbard, Brian K., Kaushik, Virendar K., Daniels, Douglas S.

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Novel Inhibitor Binding Site Discovery on HIV‑1 Capsid N‑Terminal Domain by NMR and X‑ray Crystallography von Goudreau, Nathalie, Lemke, Christopher T, Faucher, Anne-Marie, Grand-Maître, Chantal, Goulet, Sylvie, Lacoste, Jean-Eric, Rancourt, Jean, Malenfant, Eric, Mercier, Jean-François, Titolo, Steve, Mason, Stephen W

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Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease von Bailey, Murray D., Halmos, Teddy, Lemke, Christopher T.

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