Single-cell analysis of mixed-lineage states leading to a binary cell fate choice von Olsson, Andre, Venkatasubramanian, Meenakshi, Chaudhri, Viren K., Aronow, Bruce J., Salomonis, Nathan, Singh, Harinder, Grimes, H. Leighton

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Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes von Yáñez, Alberto, Coetzee, Simon G., Olsson, Andre, Muench, David E., Berman, Benjamin P., Hazelett, Dennis J., Salomonis, Nathan, Grimes, H. Leighton, Goodridge, Helen S.

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The Human Cell Atlas bone marrow single-cell interactive web portal von Hay, Stuart B., Ferchen, Kyle, Chetal, Kashish, Grimes, H. Leighton, Salomonis, Nathan

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Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition von Hinge, Ashwini, He, Jingyi, Bartram, James, Javier, Jose, Xu, Juying, Fjellman, Ellen, Sesaki, Hiromi, Li, Tingyu, Yu, Jie, Wunderlich, Mark, Mulloy, James, Kofron, Matthew, Salomonis, Nathan, Grimes, H. Leighton, Filippi, Marie-Dominique

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Unraveling bone marrow architecture von Lucas, Daniel, Salomonis, Nathan, Grimes, H. Leighton

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Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor von Kwok, Immanuel, Becht, Etienne, Xia, Yu, Ng, Melissa, Teh, Ye Chean, Tan, Leonard, Evrard, Maximilien, Li, Jackson L.Y., Tran, Hoa T.N., Tan, Yingrou, Liu, Dehua, Mishra, Archita, Liong, Ka Hang, Leong, Keith, Zhang, Yuning, Olsson, Andre, Mantri, Chinmay Kumar, Shyamsunder, Pavithra, Liu, Zhaoyuan, Piot, Cecile, Dutertre, Charles-Antoine, Cheng, Hui, Bari, Sudipto, Ang, Nicholas, Biswas, Subhra K., Koeffler, H. Philip, Tey, Hong Liang, Larbi, Anis, Su, I-Hsin, Lee, Bernett, St. John, Ashley, Chan, Jerry K.Y., Hwang, William Y.K., Chen, Jinmiao, Salomonis, Nathan, Chong, Shu Zhen, Grimes, H. Leighton, Liu, Bing, Hidalgo, Andrés, Newell, Evan W., Cheng, Tao, Ginhoux, Florent, Ng, Lai Guan

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DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data von DePasquale, Erica A.K., Schnell, Daniel J., Van Camp, Pieter-Jan, Valiente-Alandí, Íñigo, Blaxall, Burns C., Grimes, H. Leighton, Singh, Harinder, Salomonis, Nathan

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Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression von Lee, Jung-Mi, Govindarajah, Vinothini, Goddard, Bryan, Hinge, Ashwini, Muench, David E, Filippi, Marie-Dominique, Aronow, Bruce, Cancelas, Jose A, Salomonis, Nathan, Grimes, H Leighton, Reynaud, Damien

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Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma von Lee, Catherine, Rudneva, Vasilisa A., Erkek, Serap, Zapatka, Marc, Chau, Lianne Q., Tacheva-Grigorova, Silvia K., Garancher, Alexandra, Rusert, Jessica M., Aksoy, Ozlem, Lea, Robin, Mohammad, Helai P., Wang, Jianxun, Weiss, William A., Grimes, H. Leighton, Pfister, Stefan M., Northcott, Paul A., Wechsler-Reya, Robert J.

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cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes von DePasquale, Erica A K, Schnell, Daniel, Dexheimer, Phillip, Ferchen, Kyle, Hay, Stuart, Chetal, Kashish, Valiente-Alandí, Íñigo, Blaxall, Burns C, Grimes, H Leighton, Salomonis, Nathan

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The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification von Lu, Yi-Chien, Sanada, Chad, Xavier-Ferrucio, Juliana, Wang, Lin, Zhang, Ping-Xia, Grimes, H. Leighton, Venkatasubramanian, Meenakshi, Chetal, Kashish, Aronow, Bruce, Salomonis, Nathan, Krause, Diane S.

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MAPK-negative feedback regulation confers dependence to JAK2V617F signaling von Kesarwani, Meenu, Kincaid, Zachary, Azhar, Mohammad, Menke, Jacob, Schwieterman, Joshua, Ansari, Sekhu, Reaves, Angela, Deininger, Michael E., Levine, Ross, Grimes, H. Leighton, Azam, Mohammad

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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia von Kesarwani, Meenu, Kincaid, Zachary, Gomaa, Ahmed, Huber, Erika, Rohrabaugh, Sara, Siddiqui, Zain, Bouso, Muhammad F, Latif, Tahir, Xu, Ming, Komurov, Kakajan, Mulloy, James C, Cancelas, Jose A, Grimes, H Leighton, Azam, Mohammad

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Decision level integration of unimodal and multimodal single cell data with scTriangulate von Li, Guangyuan, Song, Baobao, Singh, Harinder, Surya Prasath, V. B., Leighton Grimes, H., Salomonis, Nathan

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Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress von Unnisa, Zeenath, Clark, Jason P., Roychoudhury, Jayeeta, Thomas, Elizabeth, Tessarollo, Lino, Copeland, Neal G., Jenkins, Nancy A., Grimes, H. Leighton, Kumar, Ashish R.

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Why Single-Cell Sequencing Has Promise in MDS von Zhang, Xuan, Grimes, H Leighton

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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes von Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T

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Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells von Goyama, Susumu, Schibler, Janet, Cunningham, Lea, Zhang, Yue, Rao, Yalan, Nishimoto, Nahoko, Nakagawa, Masahiro, Olsson, Andre, Wunderlich, Mark, Link, Kevin A, Mizukawa, Benjamin, Grimes, H Leighton, Kurokawa, Mineo, Liu, P Paul, Huang, Gang, Mulloy, James C

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Improved detection of measurable residual disease in acute myeloid leukemia von Zhang, Xuan, Grimes, H. Leighton

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Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization von Popovic, Relja, Riesbeck, Laurie E., Velu, Chinavenmeni S., Chaubey, Aditya, Zhang, Jiwang, Achille, Nicholas J., Erfurth, Frank E., Eaton, Katherine, Lu, Jun, Grimes, H. Leighton, Chen, Jianjun, Rowley, Janet D., Zeleznik-Le, Nancy J.

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