Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma von Hansen, Joshua D, Correa, Matthew, Nagy, Mark A, Alexander, Matt, Plantevin, Veronique, Grant, Virginia, Whitefield, Brandon, Huang, Dehua, Kercher, Timothy, Harris, Roy, Narla, Rama Krishna, Leisten, Jim, Tang, Yang, Moghaddam, Mehran, Ebinger, Katalin, Piccotti, Joseph, Havens, Courtney G, Cathers, Brian, Carmichael, James, Daniel, Thomas, Vessey, Rupert, Hamann, Lawrence G, Leftheris, Katerina, Mendy, Derek, Baculi, Frans, LeBrun, Laurie A, Khambatta, Gody, Lopez-Girona, Antonia

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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF von Decaris, Martin L., Schaub, Johanna R., Chen, Chun, Cha, Jacob, Lee, Gail G., Rexhepaj, Megi, Ho, Steve S., Rao, Vikram, Marlow, Megan M., Kotak, Prerna, Budi, Erine H., Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Martin, Shamra P., Huang, Shaoyi, Chen, Ming, Muñoz, Manuel, Hom, Timothy F., Wolters, Paul J., Desai, Tushar J., Rock, Fernando, Leftheris, Katerina, Morgans, David J., Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A., Turner, Scott M.

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Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations von Zheng, Yajun, Leftheris, Katerina

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists von Lotesta, Stephen D., Marcus, Andrew P., Zheng, Yajun, Leftheris, Katerina, Noto, Paul B., Meng, Shi, Kandpal, Geeta, Chen, Guozhou, Zhou, Jing, McKeever, Brian, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S., Singh, Suresh B., McGeehan, Gerard M.

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AS144 - PLN-74809, a clinical-stage, dual alphaVbeta6/alphaVbeta1 integrin inhibitor, reduces fibrosis in a preclinical model of biliary fibrosis and precision-cut liver slices fro... von Schaub, Johanna, Chen, Chun, Decaris, Martin, Ho, Steve, Lee, Gail, Rao, Vikram, Marlow, Megan, Martin, Shamra, Chen, Tony, Wu, Jianfeng, Dooka, Christina, Cha, Jake, Munoz, Manuel, Leftheris, Katerina, Gorina, Eduard, Lefebvre, Eric, Turner, Scott

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PLN-74809, a clinical-stage, dual alphaVbeta6/alphaVbeta1 integrin inhibitor, reduces fibrosis in a preclinical model of biliary fibrosis and precision-cut liver slices from primar... von Schaub, Johanna, Chen, Chun, Decaris, Martin, Ho, Steve, Lee, Gail, Rao, Vikram, Marlow, Megan, Martin, Shamra, Chen, Tony, Wu, Jianfeng, Dooka, Christina, Cha, Jake, Munoz, Manuel, Leftheris, Katerina, Gorina, Eduard, Lefebvre, Eric, Turner, Scott

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists von Lotesta, Stephen D., Marcus, Andrew P., Zheng, Yajun, Leftheris, Katerina, Noto, Paul B., Meng, Shi, Kandpal, Geeta, Chen, Guozhou, Zhou, Jing, McKeever, Brian, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S., Singh, Suresh B., McGeehan, Gerard M.

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Improved procedure for the preparation of 7-methoxy-2-methyl-1-(2-morpholinoethyl)-1H-indole-3-carboxylic acid, key intermediate in the synthesis of novel 3-amidoindole and indolop... von Zhao, Rulin, Wang, Bei, Wu, Hong, Hynes, John, Leftheris, Katerina, Balasubramanian, Balu, Barrish, Joel C., Chen, Bang-Chi

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen von Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Development of a Practical Synthesis of a p38 Kinase Inhibitor via a Safe and Robust Amination von Shi, Zhongping, Kiau, Susanne, Lobben, Paul, Hynes, John, Wu, Hong, Parlanti, Luca, Discordia, Robert, Doubleday, Wendel W, Leftheris, Katerina, Dyckman, Alaric J, Wrobleski, Stephen T, Dambalas, Konstantinos, Tummala, Srinivas, Leung, Simon, Lo, Ehrlic

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Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI) von Aldrich, Jane, Allen, Shelley, Araujo, Erika, Bronson, Joanne, Bryant-Friedrich, Amanda, Cyr, Shana K., DiMauro, Erin F., Dzierba, Carolyn, Garner, Amanda L., Georg, Gunda I., Goodwin, Nicole C., Haranahalli, Krupanandan, Huang, Rong, Leftheris, Katerina, May-Dracka, Tricia L., Olson, Margaret E., Blanco, Maria-Jesus

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Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity von Elsner, Jan, Cashion, Dan, Robinson, Dale, Bahmanyar, Sogole, Tehrani, Lida, Fultz, Kimberly E, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Apuy, Julius, LeBrun, Laurie, Leftheris, Katerina, Boylan, John F, Zhu, Dan, Riggs, Jennifer R

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The identification of novel p38I- isoform selective kinase inhibitors having an unprecedented p38I- binding mode von Wrobleski, Stephen, Lin, Shuqun, Dhar, T G, Dyckman, Alaric, Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Fan, Yi, Doweyko, Arthur, Tokarski, John, Kish, Kevin, Kiefer, Susan, Sack, John, Newitt, John, Witmer, Mark, McKinnon, Murray, Barrish, Joel, Dodd, John, Schieven, Gary, Leftheris, Katerina

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Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy von Riggs, Jennifer R, Elsner, Jan, Cashion, Dan, Robinson, Dale, Tehrani, Lida, Nagy, Mark, Fultz, Kimberly E, Krishna Narla, Rama, Peng, Xiaohui, Tran, Tam, Kulkarni, Ashutosh, Bahmanyar, Sogole, Condroski, Kevin, Pagarigan, Barbra, Fenalti, Gustavo, LeBrun, Laurie, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Empowering Voices: Inspiring Women in Medicinal Chemistry von Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy

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Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005 von Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S, Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E

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A novel one-pot synthesis of N,6-disubstituted 1,3,5-triazine-4,6-diamines from isothiocyanates and amidines von Liu, Chunjian, Lin, James, Leftheris, Katerina

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Dual inhibition of [alpha]v[beta]6 and [alpha]v[beta]1 reduces fibrogenesis in lung tissue explants from patients with IPF von Decaris, Ma, Schaub, Johanna R, Chen, Chun, Cha, Jacob, Lee, Gail G, Rexhepaj, Megi, Ho, Steve S, Rao, Vikram, Marlow, Megan M, Kotak, Prerna, Budi, Erine H, Hooi, Lisa, Wu, Jianfeng, Fridlib, Marina, Ma, Huang, Shaoyi, Chen, Ming, Muéoz, Manuel, Hom, Timothy F, Wolters, Paul J, Desai, Tushar J, Rock, Fernando, Leftheris, Katerina, Morgans, David J, Lepist, Eve-Irene, Andre, Patrick, Lefebvre, Eric A, Turner, Scott M

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Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI) von Aldrich, Jane, Allen, Shelley, Araujo, Erika, Bronson, Joanne, Bryant-Friedrich, Amanda, Cyr, Shana K., DiMauro, Erin F., Dzierba, Carolyn, Garner, Amanda L., Georg, Gunda I., Goodwin, Nicole C., Haranahalli, Krupanandan, Huang, Rong, Leftheris, Katerina, May-Dracka, Tricia L., Olson, Margaret E., Blanco, Maria-Jesus

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist von Zheng, Yajun, Zhuang, Linghang, Fan, Kristi Yi, Tice, Colin M, Zhao, Wei, Dong, Chengguo, Lotesta, Stephen D, Leftheris, Katerina, Lindblom, Peter R, Liu, Zhijie, Shimada, Jun, Noto, Paul B, Meng, Shi, Hardy, Andrew, Howard, Lamont, Krosky, Paula, Guo, Joan, Lipinski, Kerri, Kandpal, Geeta, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak, Van Orden, Rebecca, Zhou, Jing, Chen, Guozhou, Wu, Zhongren, McKeever, Brian M, McGeehan, Gerard M, Gregg, Richard E, Claremon, David A, Singh, Suresh B

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