Statins as Anticancer Agents in the Era of Precision Medicine von Longo, Joseph, van Leeuwen, Jenna E, Elbaz, Mohamad, Branchard, Emily, Penn, Linda Z

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Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins von Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Mullen, Peter J, Ba-Alawi, Wail, Haibe-Kains, Benjamin, Penn, Linda Z

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The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma von Longo, Joseph, Smirnov, Petr, Li, Zhihua, Branchard, Emily, van Leeuwen, Jenna E., Licht, Jonathan D., Haibe-Kains, Benjamin, Andrews, David W., Keats, Jonathan J., Pugh, Trevor J., Trudel, Suzanne, Penn, Linda Z.

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Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins von van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.

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An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer von Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.

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Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N -glycosylation Abundance and Branching von Yu, Rosemary, Longo, Joseph, van Leeuwen, Jenna E, Zhang, Cunjie, Branchard, Emily, Elbaz, Mohamad, Cescon, David W, Drake, Richard R, Dennis, James W, Penn, Linda Z

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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality von Lin, Peter, Lourenco, Corey, Cruickshank, Jennifer, Palomero, Luis, van Leeuwen, Jenna E, Tong, Amy H Y, Chan, Katherine, El Ghamrasni, Samah, Pujana, Miquel Angel, Cescon, David W, Moffat, Jason, Penn, Linda Z

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Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents von Leeuwen, Jenna van, Pandyra, Aleksandra, Goard, Carolyn, Mullen, Peter J., Yu, Rosemary, Penn, Linda Z.

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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality von Lin, Peter, Lourenco, Corey, Cruickshank, Jennifer, Palomero, Luis, Leeuwen, Jenna E. van, Tong, Amy H. Y, Chan, Katherine, El Ghamrasni, Samah, Pujana, Miquel Angel, Cescon, David W, Moffat, Jason, Penn, Linda Z

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