Oxidative metabolism of linoleic acid modulates PPAR-beta delta suppression of PPAR-gamma activity von Zuo, X, Wu, Y, Morris, J S, Stimmel, J B, Leesnitzer, L M, Fischer, S M, Lippman, S M, Shureiqi, I

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NF-kappa B regulates IL-1 beta transcription through a consensus NF- kappa B binding site and a nonconsensus CRE-like site von Cogswell, JP, Godlevski, MM, Wisely, GB, Clay, WC, Leesnitzer, LM, Ways, JP, Gray, JG

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The 15-Lipoxygenase-1 Product 13-S-Hydroxyoctadecadienoic Acid Down-Regulates PPAR-δ to Induce Apoptosis in Colorectal Cancer Cells von Shureiqi, Imad, Jiang, Wei, Zuo, Xiangsheng, Wu, Yuanqing, Stimmel, Julie B., Leesnitzer, Lisa M., Morris, Jeffrey S., Fan, Hui-Zhen, Fischer, Susan M., Lippman, Scott M.

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A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ von Wang, Yongping, Porter, Weston W, Suh, Nanjoo, Honda, Tadashi, Gribble, Gordon W, Leesnitzer, Lisa M, Plunket, Kelli D, Mangelsdorf, David J, Blanchard, Steven G, Willson, Timothy M, Sporn, Michael B

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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents von Henke, Brad R, Blanchard, Steven G, Brackeen, Marcus F, Brown, Kathleen K, Cobb, Jeff E, Collins, Jon L, Harrington, W. Wallace, Hashim, Mir A, Hull-Ryde, Emily A, Kaldor, Istvan, Kliewer, Steven A, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen M, Lenhard, James M, Orband-Miller, Lisa A, Miller, John F, Mook, Robert A, Noble, Stewart A, Oliver, William, Parks, Derek J, Plunket, Kelli D, Szewczyk, Jerzy R, Willson, Timothy M

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Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis von Liu, Kevin G, Lambert, Millard H, Leesnitzer, Lisa M, Oliver, William, Ott, Ronda J, Plunket, Kelli D, Stuart, Ludwig W, Brown, Peter J, Willson, Timothy M, Sternbach, Daniel D

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Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662 von Leesnitzer, Lisa M, Parks, Derek J, Bledsoe, Randy K, Cobb, Jeff E, Collins, Jon L, Consler, Thomas G, Davis, Roderick G, Hull-Ryde, Emily A, Lenhard, James M, Patel, Lisa, Plunket, Kelli D, Shenk, Jennifer L, Stimmel, Julie B, Therapontos, Christina, Willson, Timothy M, Blanchard, Steven G

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Role of PPARα in mediating the effects of phthalates and metabolites in the liver von Lapinskas, Paula J., Brown, Sherri, Leesnitzer, Lisa M., Blanchard, Steven, Swanson, Cyndi, Cattley, Russell C., Corton, J. Christopher

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A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity von Rocchi, Stéphane, Picard, Frédéric, Vamecq, Joseph, Gelman, Laurent, Potier, Noelle, Zeyer, Denis, Dubuquoy, Laurent, Bac, Pierre, Champy, Marie-France, Plunket, Kelli D., Leesnitzer, Lisa M., Blanchard, Steven G., Desreumaux, Pierre, Moras, Dino, Renaud, Jean-Paul, Auwerx, Johan

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Synthesis and biological activity of a novel series of indole-derived PPARγ agonists von Henke, Brad R., Adkison, Kimberley K., Blanchard, Steven G., Leesnitzer, Lisa M., Mook, Robert A., Plunket, Kelli D., Ray, John A., Roberson, Claudia, Unwalla, Rayomand, Willson, Timothy M.

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The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo von PLACE, Andrew E, NANJOO SUH, ROSEN, Evan, SPORN, Michael B, WILLIAMS, Charlotte R, RISINGSONG, Renee, HONDA, Tadashi, HONDA, Yukiko, GRIBBLE, Gordon W, LEESNITZER, Lisa M, STIMMEL, Julie B, WILLSON, Timothy M

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Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta von Liu, K G, Smith, J S, Ayscue, A H, Henke, B R, Lambert, M H, Leesnitzer, L M, Plunket, K D, Willson, T M, Sternbach, D D

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Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors von Thuillier, Philippe, Brash, Alan R, Kehrer, James P, Stimmel, Julie B, Leesnitzer, Lisa M, Yang, Peiying, Newman, Robert A, Fischer, Susan M

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Conjugated linoleic acid is an activator and ligand for peroxisome proliferator-activated receptor-gamma (PPARγ) von Belury, Martha A, Moya-Camarena, Silvia Y, Lu, Ming, Shi, Lingling, Leesnitzer, Lisa M, Blanchard, Steven G

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Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity von Stanley, Thomas B, Leesnitzer, Lisa M, Montana, Valerie G, Galardi, Cristin M, Lambert, Millard H, Holt, Jason A, Xu, H. Eric, Moore, Linda B, Blanchard, Steven G, Stimmel, Julie B

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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 2. Structure−Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety von Collins, Jon L, Blanchard, Steven G, Boswell, G. Evan, Charifson, Paul S, Cobb, Jeff E, Henke, Brad R, Hull-Ryde, Emily A, Kazmierski, Wieslaw M, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen, Lenhard, James M, Orband-Miller, Lisa A, Gray-Nunez, Yolanda, Parks, Derek J, Plunkett, Kelli D, Tong, Wei-Qin

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Identification of a series of oxadiazole-substituted α-isopropoxy phenylpropanoic acids with activity on PPARα, PPARγ, and PPARδ von Liu, Kevin G, Smith, Jennifer S, Ayscue, Andrea H, Henke, Brad R, Lambert, Millard H, Leesnitzer, Lisa M, Plunket, Kelli D, Willson, Timothy M, Sternbach, Daniel D

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Synthesis and biological activity of l-tyrosine-based PPARγ agonists with reduced molecular weight von Liu, Kevin G., Lambert, Millard H., Ayscue, Andrea H., Henke, Brad R., Leesnitzer, Lisa M., Oliver, Jr, William R., Plunket, Kelli D., Xu, H.Eric, Sternbach, Daniel D., Willson, Timothy M.

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Helix 1/8 Interactions Influence the Activity of Nuclear Receptor Ligand-Binding Domains von Holt, Jason A, Consler, Thomas G, Williams, Shawn P, Ayscue, Andrea H, Leesnitzer, Lisa M, Wisely, G. Bruce, Billin, Andrew N

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A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity von Rocchi, S, Picard, F, Vamecq, J, Gelman, L, Potier, N, Zeyer, D, Dubuquoy, L, Bac, P, Champy, M F, Plunket, K D, Leesnitzer, L M, Blanchard, S G, Desreumaux, P, Moras, D, Renaud, J P, Auwerx, J

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