High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases von Jia, X, Crawford, JC, Gebregzabher, D, Monson, EA, Mettelman, RC, Wan, Y, Ren, Y, Chou, J, Novak, T, McQuilten, HA, Clarke, M, Bachem, A, Foo, IJ, Fritzlar, S, Carrera Montoya, J, Trenerry, AM, Nie, S, Leeming, MG, Nguyen, THO, Kedzierski, L, Littler, DR, Kueh, A, Cardamone, T, Wong, CY, Hensen, L, Cabug, A, Laguna, JG, Agrawal, M, Flerlage, T, Boyd, DF, Van de Velde, L-A, Habel, JR, Loh, L, Koay, H-F, Van de Sandt, CE, Konstantinov, IE, Berzins, SP, Flanagan, KL, Wakim, LM, Herold, MJ, Green, AM, Smallwood, HS, Rossjohn, J, Thwaites, RS, Chiu, C, Scott, NE, Mackenzie, JM, Bedoui, S, Reading, PC, Londrigan, SL, Helbig, KJ, Randolph, AG, Thomas, PG, Xu, J, Wang, Z, Chua, BY, Kedzierska, K

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Nontargeted Identification of Plasma Proteins O-, N-, and S-Transmethylated by O-Methyl Organophosphates von Wang, H, Leeming, MG, Cochran, BJ, Hook, JM, Ho, J, Nguyen, GTH, Zhong, L, Supuran, CT, Donald, WA

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Origin and Prediction of Highly Specific Bond Cleavage Sites in the Thermal Activation of Intact Protein Ions von Wang, H, Leeming, MG, Ho, J, Donald, WA

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Changes in hospital mortality in patients with cancer during the COVID-19 pandemic (ISARIC-CCP-UK): a prospective, multicentre cohort study von Turtle, L, Elliot, S, Drake, TM, Thorpe, M, Khoury, EG, Greenhalf, W, Hardwick, HE, Leeming, G, Law, A, Oosthuyzen, W, Pius, R, Shaw, CA, Baillie, JK, Openshaw, PJM, Docherty, AB, Semple, MG, Harrison, EM, Palmieri, C, ISARIC4C Investigators

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A hybrid architecture (CO-CONNECT) to facilitate rapid discovery and access to data across the United Kingdom in response to the COVID-19 pandemic: development study von Jefferson, E, Cole, C, Mumtaz, S, Cox, S, Giles, TC, Adejumo, S, Urwin, E, Lea, D, Macdonald, C, Best, J, Masood, E, Milligan, G, Johnston, J, Horban, S, Birced, I, Hall, C, Jackson, AS, Collins, C, Rising, S, Dodsley, C, Hampton, J, Hadfield, A, Santos, R, Tarr, S, Panagi, V, Lavagna, J, Jackson, T, Chuter, A, Beggs, J, Martinez-Queipo, M, Ward, H, Von Ziegenweidt, J, Burns, F, Martin, J, Sebire, N, Morris, C, Bradley, D, Baxter, R, Ahonen-Bishopp, A, Smith, P, Shoemark, A, Valdes, AM, Ollivere, B, Manisty, C, Eyre, D, Gallant, S, Joy, G, McAuley, A, Connell, D, Northstone, K, Jeffery, K, Di Angelantonio, E, McMahon, A, Walker, M, Semple, MG, Sims, JM, Lawrence, E, Davies, B, Baillie, JK, Tang, M, Leeming, G, Power, L, Breeze, T, Murray, D, Orton, C, Pierce, I, Hall, I, Ladhani, S, Gillson, N, Whitaker, M, Shallcross, L, Seymour, D, Varma, S, Reilly, G, Morris, A, Hopkins, S, Sheikh, A, Quinlan, P

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Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK von Docherty, AB, Mulholland, RH, Lone, NI, Cheyne, CP, De Angelis, D, Diaz-Ordaz, K, Donegan, C, Drake, TM, Dunning, J, Funk, S, García-Fiñana, M, Girvan, M, Hardwick, HE, Harrison, J, Ho, A, Hughes, DM, Keogh, RH, Kirwan, PD, Leeming, G, Nguyen Van-Tam, JS, Pius, R, Russell, CD, Spencer, RG, Tom, BD, Turtle, L, Openshaw, PJ, Baillie, JK, Harrison, EM, Semple, MG, ISARIC4C Investigators

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Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study von Närhi, F, Moonesinghe, SR, Shenkin, SD, Drake, TM, Mulholland, RH, Donegan, C, Dunning, J, Fairfield, CJ, Girvan, M, Hardwick, HE, Ho, A, Leeming, G, Nguyen-Van-Tam, JS, Pius, R, Russell, CD, Shaw, CA, Spencer, RG, Turtle, L, Openshaw, PJM, Baillie, JK, Harrison, EM, Semple, MG, Docherty, AB, ISARIC4C investigators

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Towards nationally curated data archives for clinical radiology image analysis at scale: learnings from national data collection in response to a pandemic von Cushnan, D, Berka, R, Bertolli, O, Williams, P, Schofield, D, Joshi, I, Favaro, A, Halling-Brown, M, Imreh, G, Jefferson, E, Sebire, NJ, Reilly, G, Rodrigues, JCL, Robinson, G, Copley, S, Malik, R, Bloomfield, C, Gleeson, F, Crotty, M, Denton, E, Dickson, J, Leeming, G, Hardwick, HE, Baillie, K, Openshaw, PJM, Semple, MG, Rubin, C, Howlett, A, Rockall, AG, Bhayat, A, Fascia, D, Sudlow, C, Jacob, J

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Cirrhotic human liver extracellular matrix 3D scaffolds promote smad-dependent TGF-β1 epithelial mesenchymal transition von Mazza, G, Telese, A, Al-Akkad, W, Frenguelli, L, Levi, A, Marrali, M, Longato, L, Thanapirom, K, Vilia, MG, Lombardi, B, Crowley, C, Crawford, M, Karsdal, MA, Leeming, DJ, Marrone, G, Bottcher, K, Robinson, B, Del Rio Hernandez, A, Tamburrino, D, Spoletini, G, Malago, M, Hall, AR, Godovac-Zimmermann, J, Luong, TV, De Coppi, P, Pinzani, M, Rombouts, K

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Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 von Siggins, MK, Davies, K, Fellows, R, Thwaites, RS, Baillie, JK, Semple, MG, Openshaw, PJM, Zelek, WM, Harris, CL, Morgan, BP, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Docherty, AB, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, CA, Harrison, EM, Hiscox, JA, Ho, AYW, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC, Palmarini, M, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Russell, CD, Sancho-Shimizu, V, Scott, JT, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thomson, EC, Thompson, AAR, Turtle, LCW, Gupta, RK, Zambon, M, Hardwick, H, Donohue, C, Lyons, R, Griffiths, F, Oosthuyzen, W, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Clohisey, S, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, McDonald, S, Keating, S, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL

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Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK von Docherty, AB, Mulholland, RH, Lone, NI, Cheyne, CP, De Angelis, D, Diaz-Ordaz, K, Donegan, C, Drake, TM, Dunning, J, Funk, S, García-Fiñana, M, Girvan, M, Hardwick, HE, Harrison, J, Ho, A, Hughes, DM, Keogh, RH, Kirwan, PD, Leeming, G, Nguyen Van-Tam, JS, Pius, R, Russell, CD, Spencer, RG, Tom, BD, Turtle, L, Openshaw, PJ, Baillie, JK, Harrison, EM, Semple, MG, ISARIC4C Investigators

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Towards nationally curated data archives for clinical radiology image analysis at scale: Learnings from national data collection in response to a pandemic von Cushnan, D, Berka, R, Bertolli, O, Williams, P, Schofield, D, Joshi, I, Favaro, A, Halling-Brown, M, Imreh, G, Jefferson, E, Sebire, NJ, Reilly, G, Rodrigues, JCL, Robinson, G, Copley, S, Malik, R, Bloomfield, C, Gleeson, F, Crotty, M, Denton, E, Dickson, J, Leeming, G, Hardwick, HE, Baillie, K, Openshaw, PJM, Semple, MG, Rubin, C, Howlett, A, Rockall, AG, Bhayat, A, Fascia, D, Sudlow, C, Jacob, J

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Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study von Närhi, F, Moonesinghe, SR, Shenkin, SD, Drake, TM, Mulholland, RH, Donegan, C, Dunning, J, Fairfield, CJ, Girvan, M, Hardwick, HE, Ho, A, Leeming, G, Nguyen-Van-Tam, JS, Pius, R, Russell, CD, Shaw, CA, Spencer, RG, Turtle, L, Openshaw, PJM, Baillie, JK, Harrison, EM, Semple, MG, Docherty, AB, Openshaw, PJ, Carson, G, Alex, B, Andrikopoulos, P, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Chechi, K, Cooke, GS, da Silva Filipe, A, de Silva, T, dos Santos Correia, G, Dumas, ME, Fletcher, T, Green, CA, Greenhalf, W, Griffin, J, Gupta, RK, Hiscox, JA, Ho, AY, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lewis, M, Liggi, S, Lim, WS, Maslen, L, Mentzer, AJ, Merson, L, Meynert, AM, Moore, SC, Noursadeghi, M, Olanipekun, M, Osagie, A, Palmarini, M, Palmieri, C, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Sancho-Shimizu, V, Sands, C, Scott, JT, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Swann, OV, Takats, Z, Takis, P, Tedder, RS, Thompson, AR, Thomson, EC, Thwaites, RS, Turtle, LC, Zambon, M, Donohue, C, Griffiths, F, Oosthuyzen, W, Norman, L, Knight, SR, Mclean, KA, Murphy, D, Dalton, J, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C

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Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition von Mazza, G, Telese, A, Al-Akkad, W, Frenguelli, L, Levi, A, Marrali, M, Longato, L, Thanapirom, K, Vilia, MG, Lombardi, B, Crowley, C, Crawford, M, Karsdal, MA, Leeming, DJ, Marrone, G, Bottcher, K, Robinson, B, Del Rio Hernandez, A, Tamburrino, D, Spoletini, G, Malago, M, Hall, AR, Godovac-Zimmermann, J, Luong, TV, De Coppi, P, Pinzani, M, Rombouts, K

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Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WH... von Bloom, CI, Drake, TM, Docherty, AB, Lipworth, BJ, Johnston, SL, Nguyen-Van-Tam, JS, Carson, G, Dunning, J, Harrison, EM, Baillie, JK, Semple, MG, Cullinan, P, Openshaw, PJM, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Filipe, AD, Fletcher, T, Green, CA, Hiscox, JA, Ho, AY, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC, Palmarini, M, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Robertson, DL, Russell, CD, Sancho-Shimizu, V, Scott, JT, Silva, TD, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thomson, EC, Thompson, AR, Thwaites, RS, Turtle, LC, Zambon, M, Hardwick, H, Donohue, C, Lyons, R, Griffiths, F, Oosthuyzen, W, Norman, L, Pius, R, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Leeming, G, Wham, M, Clohisey, S, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, McDonald, S, Keating, S, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K, Catterall, BW, Clark, JJ, Clarke, EA, Cole, S

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