Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy von Honigberg, Lee A, Smith, Ashley M, Sirisawad, Mint, Verner, Erik, Loury, David, Chang, Betty, Li, Shyr, Pan, Zhengying, Thamm, Douglas H, Miller, Richard A, Buggy, Joseph J

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ABBY: A phase 2 randomized trial of crenezumab in mild to moderate Alzheimer disease von Cummings, Jeffrey L, Cohen, Sharon, van Dyck, Christopher H, Brody, Mark, Curtis, Craig, Cho, William, Ward, Michael, Friesenhahn, Michel, Rabe, Christina, Brunstein, Flavia, Quartino, Angelica, Honigberg, Lee A, Fuji, Reina N, Clayton, David, Mortensen, Deborah, Ho, Carole, Paul, Robert

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Phase 1 Study of the Anti-HtrA1 Antibody-binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-related Macular Degeneration von Khanani, Arshad M., Hershberger, Vrinda S., Pieramici, Dante J., Khurana, Rahul N., Brunstein, Flavia, Ma, Ling, Maass, Katie F., Honigberg, Lee A., Tom, Irene, Chen, Hao, Strauss, Erich C., Lai, Phillip

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Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mil... von Salloway, Stephen, Honigberg, Lee A, Cho, William, Ward, Michael, Friesenhahn, Michel, Brunstein, Flavia, Quartino, Angelica, Clayton, David, Mortensen, Deborah, Bittner, Tobias, Ho, Carole, Rabe, Christina, Schauer, Stephen P, Wildsmith, Kristin R, Fuji, Reina N, Suliman, Shehnaaz, Reiman, Eric M, Chen, Kewei, Paul, Robert

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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase von Pan, Zhengying, Scheerens, Heleen, Li, Shyr-Jiann, Schultz, Brian E., Sprengeler, Paul A., Burrill, L. Chuck, Mendonca, Rohan V., Sweeney, Michael D., Scott, Keana C. K., Grothaus, Paul G., Jeffery, Douglas A., Spoerke, Jill M., Honigberg, Lee A., Young, Peter R., Dalrymple, Stacie A., Palmer, James T.

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Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics von Wildsmith, Kristin R, Schauer, Stephen P, Smith, Ashley M, Arnott, David, Zhu, Yuda, Haznedar, Joshua, Kaur, Surinder, Mathews, W Rodney, Honigberg, Lee A

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Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor von MacGlashan, Donald, Honigberg, Lee A., Smith, Ashley, Buggy, Joseph, Schroeder, John T.

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Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF von Spellman, Daniel S., Wildsmith, Kristin R., Honigberg, Lee A., Tuefferd, Marianne, Baker, David, Raghavan, Nandini, Nairn, Angus C., Croteau, Pascal, Schirm, Michael, Allard, Rene, Lamontagne, Julie, Chelsky, Daniel, Hoffmann, Steven, Potter, William Z.

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Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer's disease von Yoshida, Kenta, Moein, Anita, Bittner, Tobias, Ostrowitzki, Susanne, Lin, Helen, Honigberg, Lee, Jin, Jin Y., Quartino, Angelica

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Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22 von Wu, Jiansheng, Katrekar, Anjali, Honigberg, Lee A., Smith, Ashley M., Conn, Marion T., Tang, Jie, Jeffery, Doug, Mortara, Kyle, Sampang, Jun, Williams, Steve R., Buggy, Joseph, Clark, James M.

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Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer's disease pathophysiology von Schauer, Stephen P, Toth, Balazs, Lee, Julie, Honigberg, Lee A, Ramakrishnan, Vidya, Jiang, Jenny, Kollmorgen, Gwendlyn, Bayfield, Anna, Wild, Norbert, Hoffman, Jennifer, Ceniceros, Ryan, Dolton, Michael, Bohórquez, Sandra M Sanabria, Hoogenraad, Casper C, Wildsmith, Kristin R, Teng, Edmond, Monteiro, Cecilia, Anania, Veronica, Yeh, Felix L

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Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays von Schauer, Stephen P, Mylott, Jr, William R, Yuan, Moucun, Jenkins, Rand G, Rodney Mathews, W, Honigberg, Lee A, Wildsmith, Kristin R

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Preanalytical approaches to improve recovery of amyloid-[beta] peptides from CSF as measured by immunological or mass spectrometry-based assays von Schauer, Stephen P, Mylott, William R, Yuan, Moucun, Jenkins, Rand G, Rodney Mathews, W, Honigberg, Lee A, Wildsmith, Kristin R

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Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position von Harris, J, Honigberg, L, Robinson, N, Kenyon, C

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BASELINE RECOVERY AND LONGITUDINAL STABILITY OF CEREBROSPINAL FLUID AMYLOID-β PEPTIDES: AN EVALUATION OF COLLECTION METHODS, LONGITUDINAL ASSAY PERFORMANCE, AND BIOMARKER STABILITY... von Schauer, Stephen, Wildsmith, Kristin R., Rabe, Christina, Honigberg, Lee

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Systems genomics in age-related macular degeneration von den Hollander, Anneke I, Mullins, Robert F, Orozco, Luz D, Voigt, Andrew P, Chen, Hsu-Hsin, Strunz, Tobias, Grassmann, Felix, Haines, Jonathan L, Kuiper, Jonas J W, Tumminia, Santa J, Allikmets, Rando, Hageman, Gregory S, Stambolian, Dwight, Klaver, Caroline C W, Boeke, Jef D, Chen, Hao, Honigberg, Lee, Katti, Suresh, Frazer, Kelly A, Weber, Bernhard H F, Gorin, Michael B

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Inter-Reader Agreement and Longitudinal Progression of Incomplete/Complete Retinal Pigment Epithelium and Outer Retinal Atrophy in AMD von Schmitz-Valckenberg, Steffen, Saßmannshausen, Marlene, Braun, Martina, Steffen, Verena, Gao, Simon S, Honigberg, Lee, Ferrara, Daniela, Pfau, Maximilian, Holz, Frank G

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Effects of aliquot size, Tween-20 and tube type on beta-amyloid 42, tau and p-tau(181) measurements von Schauer, Stephen, Wildsmith, Kristin, Honigberg, Lee

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Interreader Agreement and Longitudinal Progression of Incomplete/Complete Retinal Pigment Epithelium and Outer Retinal Atrophy in Age-Related Macular Degeneration von Schmitz-Valckenberg, Steffen, Saßmannshausen, Marlene, Braun, Martina, Steffen, Verena, Gao, Simon S., Honigberg, Lee, Ferrara, Daniela, Pfau, Maximilian, Holz, Frank G.

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CLINICAL TRIAL DESIGN OF CREAD: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP PHASE 3 STUDY TO EVALUATE CRENEZUMAB TREATMENT IN PATIENTS WITH PRODROMAL-TO-MILD ALZ... von Blaettler, Thomas, Smith, Janice, Smith, Jillian, Paul, Robert, Asnaghi, Veronica, Fuji, Reina, Quartino, Angelica, Honigberg, Lee, Rabbia, Michael A, Yule, Susan, Ostrowitzki, Susanne, Fontoura, Paulo

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