Metabolic network failures in Alzheimer's disease—A biochemical road map von Toledo, Jon B, Arnold, Matthias, Kastenmüller, Gabi, Chang, Rui, Baillie, Rebecca A, Han, Xianlin, Thambisetty, Madhav, Tenenbaum, Jessica D, Suhre, Karsten, Thompson, J. Will, John-Williams, Lisa St, MahmoudianDehkordi, Siamak, Rotroff, Daniel M, Jack, John R, Motsinger-Reif, Alison, Risacher, Shannon L, Blach, Colette, Lucas, Joseph E, Massaro, Tyler, Louie, Gregory, Zhu, Hongjie, Dallmann, Guido, Klavins, Kristaps, Koal, Therese, Kim, Sungeun, Nho, Kwangsik, Shen, Li, Casanova, Ramon, Varma, Sudhir, Legido-Quigley, Cristina, Moseley, M. Arthur, Zhu, Kuixi, Henrion, Marc Y.R, van der Lee, Sven J, Harms, Amy C, Demirkan, Ayse, Hankemeier, Thomas, van Duijn, Cornelia M, Trojanowski, John Q, Shaw, Leslie M, Saykin, Andrew J, Weiner, Michael W, Doraiswamy, P. Murali, Kaddurah-Daouk, Rima

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Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts von Tynkkynen, Juho, Chouraki, Vincent, van der Lee, Sven J., Hernesniemi, Jussi, Yang, Qiong, Li, Shuo, Beiser, Alexa, Larson, Martin G., Sääksjärvi, Katri, Shipley, Martin J., Singh-Manoux, Archana, Gerszten, Robert E., Wang, Thomas J., Havulinna, Aki S., Würtz, Peter, Fischer, Krista, Demirkan, Ayse, Ikram, M. Arfan, Amin, Najaf, Lehtimäki, Terho, Kähönen, Mika, Perola, Markus, Metspalu, Andres, Kangas, Antti J., Soininen, Pasi, Ala-Korpela, Mika, Vasan, Ramachandran S., Kivimäki, Mika, van Duijn, Cornelia M., Seshadri, Sudha, Salomaa, Veikko

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The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study von van der Lee, Sven J, Wolters, Frank J, Ikram, M Kamran, Hofman, Albert, Ikram, M Arfan, Amin, Najaf, van Duijn, Cornelia M

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Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status von Le Borgne, Julie, Amouyel, Philippe, Andreassen, Ole, Frikke‐Schmidt, Ruth, Hiltunen, Mikko, Ingelsson, Martin, Ramirez, Alfredo, Rossi, Giacomina, Ruiz, Agustin, Sanchez‐Juan, Pascual, Sims, Rebecca, Sleegers, Kristel, Tsolaki, Magda, Lee, Sven J., Williams, Julie, Lambert, Jean‐Charles, Bellenguez, Céline

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The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease von Boon, Baayla D. C., Bulk, Marjolein, Jonker, Allert J., Morrema, Tjado H. J., van den Berg, Emma, Popovic, Marko, Walter, Jochen, Kumar, Sathish, van der Lee, Sven J., Holstege, Henne, Zhu, Xiaoyue, Van Nostrand, William E., Natté, Remco, van der Weerd, Louise, Bouwman, Femke H., van de Berg, Wilma D. J., Rozemuller, Annemieke J. M., Hoozemans, Jeroen J. M.

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Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies von van der Lee, Sven J., Teunissen, Charlotte E., Pool, René, Shipley, Martin J., Teumer, Alexander, Chouraki, Vincent, Melo van Lent, Debora, Tynkkynen, Juho, Fischer, Krista, Hernesniemi, Jussi, Haller, Toomas, Singh-Manoux, Archana, Verhoeven, Aswin, Willemsen, Gonneke, de Leeuw, Francisca A., Wagner, Holger, van Dongen, Jenny, Hertel, Johannes, Budde, Kathrin, Willems van Dijk, Ko, Weinhold, Leonie, Ikram, M. Arfan, Pietzner, Maik, Perola, Markus, Wagner, Michael, Friedrich, Nele, Slagboom, P. Eline, Scheltens, Philip, Yang, Qiong, Gertzen, Robert E., Egert, Sarah, Li, Shuo, Hankemeier, Thomas, van Beijsterveldt, Catharina E.M., Vasan, Ramachandran S., Maier, Wolfgang, Peeters, Carel F.W., Jörgen Grabe, Hans, Ramirez, Alfredo, Seshadri, Sudha, Metspalu, Andres, Kivimäki, Mika, Salomaa, Veikko, Demirkan, Ayşe, Boomsma, Dorret I., van der Flier, Wiesje M., Amin, Najaf, van Duijn, Cornelia M.

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Alzheimer's disease clinical variants show distinct neuroinflammatory profiles with neuropathology von Boon, Baayla D. C., Frigerio, Irene, Gooijer, Danae, Morrema, Tjado H. J., Bol, John, Galis ‐ de Graaf, Yvon, Heymans, Martijn, Murray, Melissa E., Lee, Sven J., Holstege, Henne, Berg, Wilma D. J., Jonkman, Laura E., Rozemuller, Annemieke J. M., Bouwman, Femke H., Hoozemans, Jeroen J. M.

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PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment von Kleineidam, Luca, Chouraki, Vincent, Próchnicki, Tomasz, van der Lee, Sven J., Madrid-Márquez, Laura, Wagner-Thelen, Holger, Karaca, Ilker, Weinhold, Leonie, Wolfsgruber, Steffen, Boland, Anne, Martino Adami, Pamela V., Lewczuk, Piotr, Popp, Julius, Brosseron, Frederic, Jansen, Iris E., Hulsman, Marc, Kornhuber, Johannes, Peters, Oliver, Berr, Claudine, Heun, Reinhard, Frölich, Lutz, Tzourio, Christophe, Dartigues, Jean-François, Hüll, Michael, Espinosa, Ana, Hernández, Isabel, de Rojas, Itziar, Orellana, Adelina, Valero, Sergi, Stringa, Najada, van Schoor, Natasja M., Huisman, Martijn, Scheltens, Philip, Rüther, Eckart, Deleuze, Jean-Francois, Wiltfang, Jens, Tarraga, Lluis, Schmid, Matthias, Scherer, Martin, Riedel-Heller, Steffi, Heneka, Michael T., Amouyel, Philippe, Jessen, Frank, Boada, Merce, Maier, Wolfgang, Schneider, Anja, González-Pérez, Antonio, van der Flier, Wiesje M., Wagner, Michael, Lambert, Jean-Charles, Holstege, Henne, Sáez, Mª Eugenia, Latz, Eicke, Ruiz, Agustin, Ramirez, Alfredo

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The global impact of non-communicable diseases on healthcare spending and national income: a systematic review von Muka, Taulant, Imo, David, Jaspers, Loes, Colpani, Veronica, Chaker, Layal, van der Lee, Sven J., Mendis, Shanthi, Chowdhury, Rajiv, Bramer, Wichor M., Falla, Abby, Pazoki, Raha, Franco, Oscar H.

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Haplotype reference consortium panel: Practical implications of imputations with large reference panels von Iglesias, Adriana I., der Lee, Sven J., Bonnemaijer, Pieter W.M., Höhn, René, Nag, Abhishek, Gharahkhani, Puya, Khawaja, Anthony P., Broer, Linda, Foster, Paul J., Hammond, Christopher J., Hysi, Pirro G., Leeuwen, Elisabeth M., MacGregor, Stuart, Mackey, David A., Mazur, Johanna, Nickels, Stefan, Uitterlinden, André G., Klaver, Caroline C.W., Amin, Najaf, Duijn, Cornelia M.

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SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network von Hung, Christy, Tuck, Eleanor, Stubbs, Victoria, van der Lee, Sven J., Aalfs, Cora, van Spaendonk, Resie, Scheltens, Philip, Hardy, John, Holstege, Henne, Livesey, Frederick J.

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Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study von Ahmad, Shahzad, Bannister, Christian, van der Lee, Sven J., Vojinovic, Dina, Adams, Hieab H.H., Ramirez, Alfredo, Escott-Price, Valentina, Sims, Rebecca, Baker, Emily, Williams, Julie, Holmans, Peter, Vernooij, Meike W., Ikram, M. Arfan, Amin, Najaf, van Duijn, Cornelia M.

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Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome‐wide association study in over 12,000 non‐demented participants von Damotte, Vincent, Lee, Sven J., Chouraki, Vincent, Grenier‐Boley, Benjamin, Simino, Jeannette, Adams, Hieab, Tosto, Giuseppe, White, Charles, Terzikhan, Natalie, Cruchaga, Carlos, Knol, Maria J., Li, Shuo, Schraen, Susanna, Grove, Megan L., Satizabal, Claudia, Amin, Najaf, Berr, Claudine, Younkin, Steven, Gottesman, Rebecca F., Buée, Luc, Beiser, Alexa, Knopman, David S., Uitterlinden, Andre, DeCarli, Charles, Bressler, Jan, DeStefano, Anita, Dartigues, Jean‐François, Yang, Qiong, Boerwinkle, Eric, Tzourio, Christophe, Fornage, Myriam, Ikram, M. Arfan, Amouyel, Philippe, Jager, Phil, Reitz, Christiane, Mosley, Thomas H., Lambert, Jean‐Charles, Seshadri, Sudha, Duijn, Cornelia M.

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Risk of dementia in APOE ε4 carriers is mitigated by a polygenic risk score von Ebenau, Jarith L., Lee, Sven J., Hulsman, Marc, Tesi, Niccolò, Jansen, Iris E., Verberk, Inge M.W., Leeuwenstijn, Mardou, Teunissen, Charlotte E., Barkhof, Frederik, Prins, Niels D., Scheltens, Philip, Holstege, Henne, Berckel, Bart N.M., Flier, Wiesje M.

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Blood-based metabolic signatures in Alzheimer's disease von de Leeuw, Francisca A., Peeters, Carel F.W., Kester, Maartje I., Harms, Amy C., Struys, Eduard A., Hankemeier, Thomas, van Vlijmen, Herman W.T., van der Lee, Sven J., van Duijn, Cornelia M., Scheltens, Philip, Demirkan, Ayşe, van de Wiel, Mark A., van der Flier, Wiesje M., Teunissen, Charlotte E.

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The association of vascular disorders with incident dementia in different age groups von Legdeur, Nienke, van der Lee, Sven J, de Wilde, Marcel, van der Lei, Johan, Muller, Majon, Maier, Andrea B, Visser, Pieter Jelle

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The global impact of non-communicable diseases on households and impoverishment: a systematic review von Jaspers, Loes, Colpani, Veronica, Chaker, Layal, van der Lee, Sven J., Muka, Taulant, Imo, David, Mendis, Shanthi, Chowdhury, Rajiv, Bramer, Wichor M., Falla, Abby, Pazoki, Raha, Franco, Oscar H.

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Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease von Tesi, Niccolò, van der Lee, Sven J, Hulsman, Marc, Jansen, Iris E, Stringa, Najada, van Schoor, Natasja, Meijers-Heijboer, Hanne, Huisman, Martijn, Scheltens, Philip, Reinders, Marcel J T, van der Flier, Wiesje M, Holstege, Henne

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Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease von Visser, Pieter Jelle, Reus, Lianne M, Gobom, Johan, Jansen, Iris, Dicks, Ellen, van der Lee, Sven J, Tsolaki, Magda, Verhey, Frans R J, Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Freund-Levi, Yvonne, Froelich, Lutz, Sleegers, Kristel, Dobricic, Valerija, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie J B, Bos, Isabelle, Smit, August B, Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E, Bertram, Lars, Zetterberg, Henrik, Tijms, Betty M

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The global impact of non-communicable diseases on macro-economic productivity: a systematic review von Chaker, Layal, Falla, Abby, van der Lee, Sven J., Muka, Taulant, Imo, David, Jaspers, Loes, Colpani, Veronica, Mendis, Shanthi, Chowdhury, Rajiv, Bramer, Wichor M., Pazoki, Raha, Franco, Oscar H.

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