Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis von Lefebvre, Eric, Moyle, Graeme, Reshef, Ran, Richman, Lee P, Thompson, Melanie, Hong, Feng, Chou, Hsin-L, Hashiguchi, Taishi, Plato, Craig, Poulin, Dominic, Richards, Toni, Yoneyama, Hiroyuki, Jenkins, Helen, Wolfgang, Grushenka, Friedman, Scott L

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Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting von Bear, Adham S., Blanchard, Tatiana, Cesare, Joseph, Ford, Michael J., Richman, Lee P., Xu, Chong, Baroja, Miren L., McCuaig, Sarah, Costeas, Christina, Gabunia, Khatuna, Scholler, John, Posey, Avery D., O’Hara, Mark H., Smole, Anze, Powell, Daniel J., Garcia, Benjamin A., Vonderheide, Robert H., Linette, Gerald P., Carreno, Beatriz M.

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Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis von Moy, Ryan H., Huffman, Austin P., Richman, Lee P., Crisalli, Lisa, Wang, Ximi K., Hoxie, James A., Mick, Rosemarie, Emerson, Stephen G., Zhang, Yi, Vonderheide, Robert H., Porter, David L., Reshef, Ran

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Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma von Bajor, David L., Mick, Rosemarie, Riese, Matthew J., Huang, Alex C., Sullivan, Brendan, Richman, Lee P., Torigian, Drew A., George, Sangeeth M., Stelekati, Erietta, Chen, Fang, Melenhorst, J. Joseph, Lacey, Simon F., Xu, Xiaowei, Wherry, E. John, Gangadhar, Tara C., Amaravadi, Ravi K., Schuchter, Lynn M., Vonderheide, Robert H.

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ClonoCluster: A method for using clonal origin to inform transcriptome clustering von Richman, Lee P., Goyal, Yogesh, Jiang, Connie L., Raj, Arjun

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Neoantigen Dissimilarity to the Self-Proteome Predicts Immunogenicity and Response to Immune Checkpoint Blockade von Richman, Lee P., Vonderheide, Robert H., Rech, Andrew J.

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Tumor cell–intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2) von Markosyan, Nune, Li, Jinyang, Sun, Yu.H, Richman, Lee P, Lin, Jeffrey H, Yan, Fangxue, Quinones, Liz, Sela, Yogev, Yamazoe, Taiji, Gordon, Naomi, Tobias, John W, Byrne, Katelyn T, Rech, Andrew J, FitzGerald, Garret A, Stanger, Ben Z, Vonderheide, Robert H

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CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication von Tebas, Pablo, Jadlowsky, Julie K, Shaw, Pamela A, Tian, Lifeng, Esparza, Erin, Brennan, Andrea L, Kim, Sukyung, Naing, Soe Yu, Richardson, Max W, Vogel, Ashley N, Maldini, Colby R, Kong, Hong, Liu, Xiaojun, Lacey, Simon F, Bauer, Anya M, Mampe, Felicity, Richman, Lee P, Lee, Gary, Ando, Dale, Levine, Bruce L, Porter, David L, Zhao, Yangbing, Siegel, Don L, Bar, Katharine J, June, Carl H, Riley, James L

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Role of Crosslinking for Agonistic CD40 Monoclonal Antibodies as Immune Therapy of Cancer von RICHMAN, Lee P, VONDERHEIDE, Robert H

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Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression von Mueller, Christian, Chulay, Jeffrey D, Trapnell, Bruce C, Humphries, Margaret, Carey, Brenna, Sandhaus, Robert A, McElvaney, Noel G, Messina, Louis, Tang, Qiushi, Rouhani, Farshid N, Campbell-Thompson, Martha, Fu, Ann Dongtao, Yachnis, Anthony, Knop, David R, Ye, Guo-Jie, Brantly, Mark, Calcedo, Roberto, Somanathan, Suryanarayan, Richman, Lee P, Vonderheide, Robert H, Hulme, Maigan A, Brusko, Todd M, Wilson, James M, Flotte, Terence R

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CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication von Tebas, Pablo, Jadlowsky, Julie K, Shaw, Pamela A, Tian, Lifeng, Esparza, Erin, Brennan, Andrea L, Kim, Sukyung, Naing, Soe Yu, Richardson, Max W, Vogel, Ashley N, Maldini, Colby R, Kong, Hong, Liu, Xiaojun, Lacey, Simon F, Bauer, Anya M, Mampe, Felicity, Richman, Lee P, Lee, Gary, Ando, Dale, Levine, Bruce L, Porter, David L, Zhao, Yangbing, Siegel, Don L, Bar, Katharine J, June, Carl H, Riley, James L

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High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning von Reshef, Ran, Huffman, Austin P, Gao, Amy, Luskin, Marlise R, Frey, Noelle V, Gill, Saar I, Hexner, Elizabeth O, Kambayashi, Taku, Loren, Alison W, Luger, Selina M, Mangan, James K, Nasta, Sunita D, Richman, Lee P, Sell, Mary, Stadtmauer, Edward A, Vonderheide, Robert H, Mick, Rosemarie, Porter, David L

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Toll‐like receptor 9 and interferon‐γ receptor signaling suppress the B‐cell fate of uncommitted progenitors in mice von Baratono, Sheena R., Chu, Niansheng, Richman, Lee P., Behrens, Edward M.

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NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT von Karimi, Mobin A., Bryson, Jerrod L., Richman, Lee P., Fesnak, Andrew D., Leichner, Theresa M., Satake, Atsushi, Vonderheide, Robert H., Raulet, David H., Reshef, Ran, Kambayashi, Taku

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Anti-human CD40 monoclonal antibody therapy is potent without FcR crosslinking von Richman, Lee, Vonderheide, Robert

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Vitamin D deficiency after allogeneic hematopoietic cell transplantation promotes T-cell activation and is inversely associated with an EZH2-ID3 signature von Macedo, Rodney, Pasin, Chloé, Ganetsky, Alex, Harle, David, Wang, Ximi K., Belay, Kirubel, Richman, Lee P., Huffman, Austin P., Vonderheide, Robert H., Yates, Andrew J., Porter, David L., Wang, Ying, Zhang, Yi, Reshef, Ran

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Immune activation and a 9-year ongoing complete remission following CD40 antibody therapy and metastasectomy in a patient with metastatic melanoma von Bajor, David L, Xu, Xiaowei, Torigian, Drew A, Mick, Rosemarie, Garcia, Laura R, Richman, Lee P, Desmarais, Cindy, Nathanson, Katherine L, Schuchter, Lynn M, Kalos, Michael, Vonderheide, Robert H

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Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment von Hexner, Elizabeth O., Luger, Selina M., Reshef, Ran, Jeschke, Grace R., Mangan, James K., Frey, Noelle V., Frank, Dale M., Richman, Lee P., Vonderheide, Robert H., Aqui, Nicole A., Rosenbach, Misha, Zhang, Yi, Chew, Anne, Loren, Alison W., Stadtmauer, Edward A., Levine, Bruce L., June, Carl H., Emerson, Stephen G., Porter, David L.

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Pharmacodynamic Monitoring Predicts Outcomes of CCR5 Blockade as Graft-versus-Host Disease Prophylaxis von Huffman, Austin P., Richman, Lee P., Crisalli, Lisa, Ganetsky, Alex, Porter, David L., Vonderheide, Robert H., Reshef, Ran

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Abstract PR14: Emergence of quality metrics for neoantigens: Dissimilarity to the self-proteome as a novel determinant of immunogenicity von Richman, Lee P., Rech, Andrew J., Vonderheide, Robert H.

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