Immunophenotyping: Application to Safety Assessment von Wang, Xiaoting, Lebrec, Hervé

Volltext

Summary of a workshop on preclinical and translational safety assessment of CD3 bispecifics von Kamperschroer, Cris, Shenton, Jacintha, Lebrec, Hervé, Leighton, John K., Moore, Paul A., Thomas, Oliver

Volltext

Characterization of an Anti-CD70 Half-Life Extended Bispecific T-Cell Engager (HLE-BiTE) and Associated On-Target Toxicity in Cynomolgus Monkeys von Harper, Tod, Sharma, Amy, Kaliyaperumal, Sarav, Fajardo, Flordeliza, Hsu, Katie, Liu, Lily, Davies, Rhian, Wei, Yu-Ling, Zhan, Jinghui, Estrada, Juan, Kvesic, Majk, Nahrwold, Lisa, Deisting, Wibke, Panzer, Marc, Cooke, Keegan, Lebrec, Hervé, Nolan-Stevaux, Olivier

Volltext

Application of a newly-developed cynomolgus macaque BiTE-mediated cytotoxic T-lymphocyte activity assay to various immunomodulatory agents in vitro von Frank, Brendon, Guo, Hao, Lebrec, Hervé, Wang, Xiaoting

Volltext

Strategies to evaluate potential effector function of glycan variants: A case study of ordesekimab (AMG 714 or PRV-015) von Wei, Yu-Ling, Wegesser, Teresa, Kuhns, Scott, Werner, Jonathan, Lebrec, Hervé, Wang, Xiaoting

Volltext

Current approaches to evaluate the function of cytotoxic T-cells in non-human primates von Kamperschroer, Cris, Frank, Brendon, Genell, Caroline, Lebrec, Hervé, Mitchell-Ryan, Shermaine, Molinier, Brigitte, Newsome, Courtni, Piche, Marie-Soleil, Weinstock, Daniel, Collinge, Mark, Freebern, Wendy, Rubio, Daniel

Volltext

Regulatory Forum Opinion Piece: Immunotoxicology Assessments in Nonhuman Primates—Challenges and Opportunities von Lebrec, Hervé N.

Volltext

Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque von Frank, Brendon, Wei, Yu-Ling, Kim, Kyung-Hoon, Guerrero, Abraham, Lebrec, Hervé, Balazs, Mercedesz, Wang, Xiaoting

Volltext

The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation von Lebrec, Hervé, Molinier, Brigitte, Boverhof, Darrell, Collinge, Mark, Freebern, Wendy, Henson, Kristin, Mytych, Daniel T., Ochs, Hans D., Wange, Ronald, Yang, Yung, Zhou, Lei, Arrington, Joshua, Christin-Piché, Marie Soleil, Shenton, Jacintha

Volltext

P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors von Subramanian, Raju, Aidasani, Divesh, Bailey, Keith, Branstetter, Dan, Everds, Nancy, Jiang, Jian, Norman, Mark H, Primack, Ronya, Skiles, Gary L, Soto, Irene, Stec, Markian M, Wagner, Mylo, Wu, Tian, Zhu, Xiaochun, Lebrec, Hervé

Volltext

A summary of meeting proceedings for 'Measuring immune responses in non-human primates for drug development-Opportunities and challenges for predicting human efficacy and immunotox... von Kamperschroer, Cris, Kaur, Amitinder, Lebrec, Hervé

Volltext

Overview of the nonclinical quality and toxicology testing for recombinant biopharmaceuticals produced in mammalian cells von Lebrec, Hervé, Narayanan, Padma, Nims, Raymond

Volltext

Overview of the nonclinical quality and toxicology testing for recombinant biopharmaceuticals produced in mammalian cells von Lebrec, Hervé, Narayanan, Padma, Nims, Raymond

Volltext

Survey: Immune function and immunotoxicity assessment in dogs von Lebrec, Hervé, O'Lone, Raegan, Freebern, Wendy, Komocsar, Wendy, Moore, Peter

Volltext

An inter-laboratory retrospective analysis of immunotoxicological endpoints in non-human primates: T-cell-dependent antibody responses von Lebrec, Hervé, Cowan, Laine, Lagrou, Michelle, Krejsa, Cecile, Neradilek, Moni B., Polissar, Nayak L., Black, Lauren, Bussiere, Jeanine

Volltext

Apoptotic Responses in Squamous Carcinoma and Epithelial Cells to Small-Molecule Toll-like Receptor Agonists Evaluated with Automated Cytometry von Inglefield, Jon R., Larson, Christopher J., Gibson, Sheila J., Lebrec, Hervé, Miller, Richard L.

Volltext

Abstract 2559: Generation and evaluation of an FLT3 CAR-T cell therapy for the treatment of acute myeloid leukemia von Bakker, Alice, Lebrec, Hervé, Lindl, Bettina, Adams, Gregor, Mardiros, Armen, Koppikar, Priya, Li, Chi Ming, Gong, Mei, Zheng, Yan, Sastri, Christine, Balazs, Mercedesz, Goldstein, Rebecca, Rock, Dan, Wu, Lawren, Polverino, Anthony, Subklewe, Marion, Coxon, Angela, Arvedson, Tara

Volltext

Current Concepts in Natural Killer Cell Biology and Application to Drug Safety Assessments von Goyos, Ana, Fort, Madeline, Sharma, Amy, Lebrec, Herve

Volltext

Nonclinical safety assessment of engineered T cell therapies von Lebrec, Herve, Maier, Curtis C., Maki, Kazushige, Ponce, Rafael, Shenton, Jacintha, Green, Shon

Volltext

Characterization of Immune Phenotypes in Peripheral Blood of Adult Renal Transplant Recipients using Mass Cytometry (CyTOF) von Kowli, Sangeeta, Martinez, Olivia M, Lebrec, Herve, Minocherhomji, Sheroy, Maecker, Holden T.

Volltext