Combination of Imvotamab and Loncastuximab Tesirine Shows Enhanced Anti‐Tumor Activity in a Preclinical Model of Non‐Hodgkin’s Lymphoma von Logronio, K. A., Joglekar, M., Oyasu, M., Yakkundi, P., Leabman, M. K., Hernandez, G., Manley, T., Sinclair, A. M., Carroll, S. F., Candia, A., Keyt, B. A., Kotturi, M. F.

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Evolutionary Conservation Predicts Function of Variants of the Human Organic Cation Transporter, OCT1 von Shu, Yan, Leabman, Maya K., Feng, Bo, Mangravite, Lara M., Huang, Conrad C., Stryke, Doug, Kawamoto, Michiko, Johns, Susan J., DeYoung, Joseph, Carlson, Elaine, Ferrin, Thomas E., Herskowitz, Ira, Giacomini, Kathleen M., Pharmacogenetics of Membrane Transporters Investigators

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P1276: DOSE RESPONSE PROFILE OF IGM‐2323, A CD20XCD3 IGM BISPECIFIC T CELL ENGAGER, IN TRANSLATIONAL MODELS SUPPORTS PHASE 2 DOSE SELECTION IN NON‐HODGKIN'S LYMPHOMA von Leabman, M. K., Hernandez, G., Ng, C. M., Tang, J., Pandya, D., Hart, K. C., Li, K., Hinton, P. R., So, J., Qazi, I., Cheah, C. Y., Kim, W. S., Budde, E., Gopal, A. K., Manley, T., Takimoto, C. H., Sinclair, A. M., Carroll, S. F., Keyt, B. A., Kotturi, M. F.

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Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters von Dresser, Mark J., Leabman, Maya Kaushal, Giacomini, Kathleen M.

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Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants von Fujita, Tomoe, Urban, Thomas J., Leabman, Maya K., Fujita, Kazumi, Giacomini, Kathleen M.

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Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters von Dresser, Mark J., Leabman, Maya Kaushal, Giacomini, Kathleen M.

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Natural Variation in Human Membrane Transporter Genes Reveals Evolutionary and Functional Constraints von Leabman, Maya K., Huang, Conrad C., DeYoung, Joseph, Carlson, Elaine J., Taylor, Travis R., de la Cruz, Melanie, Johns, Susan J., Stryke, Doug, Kawamoto, Michiko, Urban, Thomas J., Kroetz, Deanna L., Ferrin, Thomas E., Clark, Andrew G., Risch, Neil, Herskowitz, Ira, Giacomini, Kathleen M., Pharmacogenetics of Membrane Transporters Investigators

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Functional genomics of membrane transporters in human populations von Urban, Thomas J, Sebro, Ronnie, Hurowitz, Evan H, Leabman, Maya K, Badagnani, Ilaria, Lagpacan, Leah L, Risch, Neil, Giacomini, Kathleen M

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Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2) von DRESSER, Mark J, GUANGQING XIAO, LEABMAN, Maya K, GRAY, Andrew T, GIACOMINI, Kathleen M

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Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function von LEABMAN, Maya K, HUANG, Conrad C, GIACOMINI, Kathleen M, KAWAMOTO, Michiko, JOHNS, Susan J, STRYKE, Douglas, FERRIN, Thomas E, DEYOUNG, Joseph, TAYLOR, Travis, CLARK, Andrew G, HERSKOWITZ, Ira

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Estimating the contribution of genes and environment to variation in renal drug clearance von LEABMAN, Maya K, GIACOMINI, Kathleen M

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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin von Chen, Ying, Li, Shuanglian, Brown, Chaline, Cheatham, Stephen, Castro, Richard A, Leabman, Maya K, Urban, Thomas J, Chen, Ligong, Yee, Sook Wah, Choi, Ji Ha, Huang, Yong, Brett, Claire M, Burchard, Esteban G, Giacomini, Kathleen M

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P815: HIGH VALENCY OF IGM‐2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING von Hart, Kevin C., Santos, Daniel, Pandya, Deepal, Deng, Rong, LI, Keyu, Guan, Yinghui, Hernandez, Genevive, Manley, Thomas, Leabman, Maya K., Hinton, Paul R., Liu, Liqin, Sinclair, Angus M., Candia, Albert F., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

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Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1) von Fujita, Tomoe, Brown, Chaline, Carlson, Elaine J, Taylor, Travis, de la Cruz, Melanie, Johns, Susan J, Stryke, Doug, Kawamoto, Michiko, Fujita, Kazumi, Castro, Richard, Chen, Chung-Wen, Lin, Emil T, Brett, Claire M, Burchard, Esteban Gonzalez, Ferrin, Thomas E, Huang, Conrad C, Leabman, Maya K, Giacomini, Kathleen M

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Abstract 52: Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity von Wang, Beatrice T., Kothambawala, Tasnim, Hart, Kevin C., Chen, Xingjie, Desbois, Melanie, Calhoun, Susan E., Yakkundi, Poonam, Rosete, Rodnie A., Cao, Yuan, Cha, Katie, Matthew, Thomas J., Wang, Ling, Hinton, Paul R., Leabman, Maya K., Hernandez, Genevive, Kotturi, Maya F., Humke, Eric W., Sinclair, Angus M., Keyt, Bruce A.

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Abstract 4120: Depletion of tissue-resident B cells by a CD20xCD3 IgM bispecific T cell engager in cynomolgus monkeys demonstrates effective tissue penetration and potent target ce... von Oyasu, Miho, Sinclair, Angus M., Ghermazien, Haben, Hernandez, Genevive, Manley, Thomas, Leabman, Maya K., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

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Abstract 4179: High valency of IGM-2323, a CD20xCD3 IgM bispecific T cell engager, displaces rituximab binding and induces potent B lymphoma cell killing von Hart, Kevin C., Logronio, Kathryn, Li, Mandy, Yakkundi, Poonam, Manlusoc, Marigold, Li, Keyu, Hinton, Paul R., Ng, Dean, Leabman, Maya K., Hernandez, Genevive, Manley, Thomas, Sinclair, Angus M., Carroll, Stephen F., Keyt, Bruce A., Kotturi, Maya F.

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Effects of RG7652, a fully human mAb against proprotein convertase subtilisin/kexin type 9, on LDL-c: a Phase I, randomised, double-blind, placebo-controlled, single- and multiple-... von Tingley, W., Luca, D., Leabman, M., Budha, N., Kahn, R., Baruch, A., Cowan, K., Davis, J. C.

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Effect of Genetic Variation in the Organic Cation Transporter 2, OCT2, on the Renal Elimination of Metformin von Chen, Ying, Li, Shuanglian, Brown, Chaline, Cheatham, Stephen, Castro, Richard A., Leabman, Maya K., Urban, Thomas J., Chen, Ligong, Yee, Sook Wah, Choi, Ji Ha, Huang, Yong, Brett, Claire M., Burchard, Esteban G., Giacomini, Kathleen M.

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Heritability of metformin renal clearance von Leabman, M., Brown, C., Chung, J., Castro, R., Swan, G. E., Lin, E., Giacomini, K. M.

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