Dimethyl fumarate, a two‐edged drug: Current status and future directions von Saidu, Nathaniel Edward Bennett, Kavian, Niloufar, Leroy, Karen, Jacob, Claus, Nicco, Carole, Batteux, Frédéric, Alexandre, Jérôme

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TP53, STK11 , and EGFR Mutations Predict Tumor Immune Profile and the Response to Anti-PD-1 in Lung Adenocarcinoma von Biton, Jérôme, Mansuet-Lupo, Audrey, Pécuchet, Nicolas, Alifano, Marco, Ouakrim, Hanane, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Goldwasser, François, Leroy, Karen, Goc, Jeremy, Wislez, Marie, Germain, Claire, Laurent-Puig, Pierre, Dieu-Nosjean, Marie-Caroline, Cremer, Isabelle, Herbst, Ronald, Blons, Hélène, Damotte, Diane

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Efficacy of Immune Checkpoint Inhibitors in Lung Sarcomatoid Carcinoma von Domblides, Charlotte, Leroy, Karen, Monnet, Isabelle, Mazières, Julien, Barlesi, Fabrice, Gounant, Valérie, Baldacci, Simon, Mennecier, Bertrand, Toffart, Anne-Claire, Audigier-Valette, Clarisse, Doucet, Ludovic, Giroux-Leprieur, Etienne, Guisier, Florian, Ricordel, Charles, Molinier, Olivier, Perol, Maurice, Pichon, Eric, Robinet, Gilles, Templement-Grangerat, Dorine, Ruppert, Anne-Marie, Rabbe, Nathalie, Antoine, Martine, Wislez, Marie

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Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease von Emile, Jean-François, Diamond, Eli L., Hélias-Rodzewicz, Zofia, Cohen-Aubart, Fleur, Charlotte, Frédéric, Hyman, David M., Kim, Eunhee, Rampal, Raajit, Patel, Minal, Ganzel, Chezi, Aumann, Shlomzion, Faucher, Gladwys, Le Gall, Catherine, Leroy, Karen, Colombat, Magali, Kahn, Jean-Emmanuel, Trad, Salim, Nizard, Philippe, Donadieu, Jean, Taly, Valérie, Amoura, Zahir, Abdel-Wahab, Omar, Haroche, Julien

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Cracking the homologous recombination deficiency code: how to identify responders to PARP inhibitors von Paulet, Lola, Trecourt, Alexis, Leary, Alexandra, Peron, Julien, Descotes, Françoise, Devouassoux-Shisheboran, Mojgan, Leroy, Karen, You, Benoit, Lopez, Jonathan

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The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort von Damotte, Diane, Warren, Sarah, Arrondeau, Jennifer, Boudou-Rouquette, Pascaline, Mansuet-Lupo, Audrey, Biton, Jérôme, Ouakrim, Hanane, Alifano, Marco, Gervais, Claire, Bellesoeur, Audrey, Kramkimel, Nora, Tlemsani, Camille, Burroni, Barbara, Duche, Angéline, Letourneur, Franck, Si, Han, Halpin, Rebecca, Creasy, Todd, Herbst, Ronald, Ren, Xing, Morel, Pascale, Cesano, Alessandra, Goldwasser, François, Leroy, Karen

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Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study von Dubois, Sydney, Viailly, Pierre-Julien, Mareschal, Sylvain, Bohers, Elodie, Bertrand, Philippe, Ruminy, Philippe, Maingonnat, Catherine, Jais, Jean-Philippe, Peyrouze, Pauline, Figeac, Martin, Molina, Thierry J, Desmots, Fabienne, Fest, Thierry, Haioun, Corinne, Lamy, Thierry, Copie-Bergman, Christiane, Brière, Josette, Petrella, Tony, Canioni, Danielle, Fabiani, Bettina, Coiffier, Bertrand, Delarue, Richard, Peyrade, Frédéric, Bosly, André, André, Marc, Ketterer, Nicolas, Salles, Gilles, Tilly, Hervé, Leroy, Karen, Jardin, Fabrice

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Clinical and molecular characteristics associated with high PD-L1 expression in EGFR-mutated lung adenocarcinoma von Slomka, Jeremy, Berthou, Hugo, Mansuet-Lupo, Audrey, Blons, Hélène, Fabre, Elizabeth, Lerner, Ivan, Rance, Bastien, Alifano, Marco, Chapron, Jeanne, Birsen, Gary, Gibault, Laure, Arrondeau, Jennifer, Leroy, Karen, Wislez, Marie

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Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma von Gunawardana, Jay, Chan, Fong Chun, Telenius, Adèle, Woolcock, Bruce, Kridel, Robert, Tan, King L, Ben-Neriah, Susana, Mottok, Anja, Lim, Raymond S, Boyle, Merrill, Rogic, Sanja, Rimsza, Lisa M, Guiter, Chrystelle, Leroy, Karen, Gaulard, Philippe, Haioun, Corinne, Marra, Marco A, Savage, Kerry J, Connors, Joseph M, Shah, Sohrab P, Gascoyne, Randy D, Steidl, Christian

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Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P-Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases von Dubois, Sydney, Viailly, Pierre-Julien, Bohers, Elodie, Bertrand, Philippe, Ruminy, Philippe, Marchand, Vinciane, Maingonnat, Catherine, Mareschal, Sylvain, Picquenot, Jean-Michel, Penther, Dominique, Jais, Jean-Philippe, Tesson, Bruno, Peyrouze, Pauline, Figeac, Martin, Desmots, Fabienne, Fest, Thierry, Haioun, Corinne, Lamy, Thierry, Copie-Bergman, Christiane, Fabiani, Bettina, Delarue, Richard, Peyrade, Frédéric, André, Marc, Ketterer, Nicolas, Leroy, Karen, Salles, Gilles, Molina, Thierry J, Tilly, Hervé, Jardin, Fabrice

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Predictive Value of Soluble PD-1, PD-L1, VEGFA, CD40 Ligand and CD44 for Nivolumab Therapy in Advanced Non-Small Cell Lung Cancer: A Case-Control Study von Meyo, Manuela Tiako, Jouinot, Anne, Giroux-Leprieur, Etienne, Fabre, Elizabeth, Wislez, Marie, Alifano, Marco, Leroy, Karen, Boudou-Rouquette, Pascaline, Tlemsani, Camille, Khoudour, Nihel, Arrondeau, Jennifer, Thomas-Schoemann, Audrey, Blons, Helene, Mansuet-Lupo, Audrey, Damotte, Diane, Vidal, Michel, Goldwasser, Francois, Alexandre, Jerome, Blanchet, Benoit

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Sarcopenic overweight is associated with early acute limiting toxicity of anti-PD1 checkpoint inhibitors in melanoma patients von Heidelberger, Valentine, Goldwasser, François, Kramkimel, Nora, Jouinot, Anne, Huillard, Olivier, Boudou-Rouquette, Pascaline, Chanal, Johan, Arrondeau, Jennifer, Franck, Nathalie, Alexandre, Jérôme, Blanchet, Benoît, Leroy, Karen, Avril, Marie-Françoise, Dupin, Nicolas, Aractingi, Sélim

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Retrospective analysis of real-world data to evaluate actionability of a comprehensive molecular profiling panel in solid tumor tissue samples (REALM study) von Leroy, Karen, Audigier Valette, Clarisse, Alexandre, Jérôme, Boussemart, Lise, Chiesa, Jean, Deldycke, Clotilde, Gomez-Rocca, Carlos, Hollebecque, Antoine, Lehmann-Che, Jacqueline, Lemoine, Antoinette, Mansard, Sandrine, Medioni, Jacques, Monnet, Isabelle, Mourah, Samia, Pierret, Thomas, Spaëth, Dominique, Civet, Alexandre, Galoin, Sandrine, Italiano, Antoine

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Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma von Mareschal, Sylvain, Dubois, Sydney, Viailly, Pierre-Julien, Bertrand, Philippe, Bohers, Elodie, Maingonnat, Catherine, Jaïs, Jean-Philippe, Tesson, Bruno, Ruminy, Philippe, Peyrouze, Pauline, Copie-Bergman, Christiane, Fest, Thierry, Jo Molina, Thierry, Haioun, Corinne, Salles, Gilles, Tilly, Hervé, Lecroq, Thierry, Leroy, Karen, Jardin, Fabrice

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Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diff... von Bohers, Elodie, Viailly, Pierre Julien, Dubois, Sydney, Bertrand, Philippe, Maingonnat, Catherine, Mareschal, Sylvain, Ruminy, Philippe, Picquenot, Jean-Michel, Bastard, Christian, Desmots, Fabienne, Fest, Thierry, Leroy, Karen, Tilly, Hervé, Jardin, Fabrice

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Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation von Viganò, Elena, Gunawardana, Jay, Mottok, Anja, Van Tol, Tessa, Mak, Katina, Chan, Fong Chun, Chong, Lauren, Chavez, Elizabeth, Woolcock, Bruce, Takata, Katsuyoshi, Twa, David, Shulha, Hennady P., Telenius, Adèle, Kutovaya, Olga, Hung, Stacy S., Healy, Shannon, Ben-Neriah, Susana, Leroy, Karen, Gaulard, Philippe, Diepstra, Arjan, Kridel, Robert, Savage, Kerry J., Rimsza, Lisa, Gascoyne, Randy, Steidl, Christian

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Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR von Suraweera, Nirosha, Duval, Alex, Reperant, Maryline, Vaury, Christelle, Furlan, Daniela, Leroy, Karen, Seruca, Raquel, Iacopetta, Barry, Hamelin, Richard

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Role of Noncoding RNA ANRIL in Genesis of Plexiform Neurofibromas in Neurofibromatosis Type 1 von Pasmant, Eric, Sabbagh, Audrey, Masliah-Planchon, Julien, Ortonne, Nicolas, Laurendeau, Ingrid, Melin, Lucie, Ferkal, Salah, Hernandez, Lucie, Leroy, Karen, Valeyrie-Allanore, Laurence, Parfait, Béatrice, Vidaud, Dominique, Bièche, Ivan, Lantieri, Laurent, Wolkenstein, Pierre, Vidaud, Michel

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The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas von Beinse, Guillaume, Just, Pierre-Alexandre, Rance, Bastien, Izac, Brigitte, Letourneur, Franck, Saidu, Nathaniel Edward Bennett, Chouzenoux, Sandrine, Nicco, Carole, Goldwasser, François, Pasmant, Eric, Batteux, Frederic, Borghese, Bruno, Alexandre, Jérôme, Leroy, Karen

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Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma von Rosenwald, Andreas, Wright, George, Leroy, Karen, Yu, Xin, Gaulard, Philippe, Gascoyne, Randy D, Chan, Wing C, Zhao, Tong, Haioun, Corinne, Greiner, Timothy C, Weisenburger, Dennis D, Lynch, James C, Vose, Julie, Armitage, James O, Smeland, Erlend B, Kvaloy, Stein, Holte, Harald, Delabie, Jan, Campo, Elias, Montserrat, Emili, Lopez-Guillermo, Armando, Ott, German, Muller-Hermelink, H Konrad, Connors, Joseph M, Braziel, Rita, Grogan, Thomas M, Fisher, Richard I, Miller, Thomas P, LeBlanc, Michael, Chiorazzi, Michael, Zhao, Hong, Yang, Liming, Powell, John, Wilson, Wyndham H, Jaffe, Elaine S, Simon, Richard, Klausner, Richard D, Staudt, Louis M

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