How to tackle antimalarial resistance? von Leroy, Didier

Volltext

Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials von Duffey, Maëlle, Blasco, Benjamin, Burrows, Jeremy N., Wells, Timothy N.C., Fidock, David A., Leroy, Didier

Volltext

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites von Delves, Michael, Plouffe, David, Scheurer, Christian, Meister, Stephan, Wittlin, Sergio, Winzeler, Elizabeth A, Sinden, Robert E, Leroy, Didier

Volltext

Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin von Platon, Lucien, Leroy, Didier, Fidock, David A, Ménard, Didier

Volltext

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay von Lelièvre, Joël, Almela, Maria Jesus, Lozano, Sonia, Miguel, Celia, Franco, Virginia, Leroy, Didier, Herreros, Esperanza

Volltext

Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials von Naude, Mariska, van Heerden, Ashleigh, Reader, Janette, van der Watt, Mariëtte, Niemand, Jandeli, Joubert, Dorè, Siciliano, Giulia, Alano, Pietro, Njoroge, Mathew, Chibale, Kelly, Herreros, Esperanza, Leroy, Didier, Birkholtz, Lyn-Marié

Volltext

Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay von Walz, Annabelle, Leroy, Didier, Andenmatten, Nicole, Mäser, Pascal, Wittlin, Sergio

Volltext

The relevance of non-human primate and rodent malaria models for humans von Langhorne, Jean, Buffet, Pierre, Galinski, Mary, Good, Michael, Harty, John, Leroy, Didier, Mota, Maria M, Pasini, Erica, Renia, Laurent, Riley, Eleanor, Stins, Monique, Duffy, Patrick

Volltext

Defining the next generation of severe malaria treatment: a target product profile von Achan, Jane, Barry, Aïssata, Leroy, Didier, Kamara, George, Duparc, Stephan, Kaszubska, Wiweka, Gandhi, Preetam, Buffet, Bénédicte, Tshilab, Patrick, Ogutu, Bernhards, Taylor, Terrie, Krishna, Sanjeev, Richardson, Naomi, Ramachandruni, Hanu, Rietveld, Hans

Volltext

The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies von Sinden, Robert E, Carter, Richard, Drakeley, Chris, Leroy, Didier

Volltext

Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages von Delves, Michael, Lafuente-Monasterio, M Jose, Upton, Leanna, Ruecker, Andrea, Leroy, Didier, Gamo, Francisco-Javier, Sinden, Robert

Volltext

African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker von Leroy, Didier, Macintyre, Fiona, Adoke, Yeka, Ouoba, Serge, Barry, Aissata, Mombo-Ngoma, Ghyslain, Ndong Ngomo, Jacques Mari, Varo, Rosauro, Dossou, Yannelle, Tshefu, Antoinette Kitoto, Duong, Tran Thanh, Phuc, Bui Quang, Laurijssens, Bart, Klopper, Roland, Khim, Nimol, Legrand, Eric, Ménard, Didier

Volltext

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults... von Adoke, Yeka, Zoleko-Manego, Rella, Ouoba, Serge, Tiono, Alfred B, Kaguthi, Grace, Bonzela, Juvêncio Eduardo, Duong, Tran Thanh, Nahum, Alain, Bouyou-Akotet, Marielle, Ogutu, Bernhards, Ouedraogo, Alphonse, Macintyre, Fiona, Jessel, Andreas, Laurijssens, Bart, Cherkaoui-Rbati, Mohammed H, Cantalloube, Cathy, Marrast, Anne Claire, Bejuit, Raphaël, White, David, Wells, Timothy N C, Wartha, Florian, Leroy, Didier, Kibuuka, Afizi, Mombo-Ngoma, Ghyslain, Ouattara, Daouda, Mugenya, Irène, Phuc, Bui Quang, Bohissou, Francis, Mawili-Mboumba, Denise P, Olewe, Fredrick, Soulama, Issiaka, Tinto, Halidou

Volltext

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination von Reader, Janette, Botha, Mariëtte, Theron, Anjo, Lauterbach, Sonja B, Rossouw, Claire, Engelbrecht, Dewaldt, Wepener, Melanie, Smit, Annél, Leroy, Didier, Mancama, Dalu, Coetzer, Theresa L, Birkholtz, Lyn-Marie

Volltext

Host-directed therapy, an untapped opportunity for antimalarial intervention von Wei, Ling, Adderley, Jack, Leroy, Didier, Drewry, David H., Wilson, Danny W., Kaushansky, Alexis, Doerig, Christian

Volltext

Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs von Mohring, Franziska, van Schalkwyk, Donelly A, Henrici, Ryan C, Blasco, Benjamin, Leroy, Didier, Sutherland, Colin J, Moon, Robert W

Volltext

A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquin... von Macintyre, Fiona, Adoke, Yeka, Tiono, Alfred B, Duong, Tran Thanh, Mombo-Ngoma, Ghyslain, Bouyou-Akotet, Marielle, Tinto, Halidou, Bassat, Quique, Issifou, Saadou, Adamy, Marc, Demarest, Helen, Duparc, Stephan, Leroy, Didier, Laurijssens, Bart E, Biguenet, Sophie, Kibuuka, Afizi, Tshefu, Antoinette Kitoto, Smith, Melnick, Foster, Chanelle, Leipoldt, Illse, Kremsner, Peter G, Phuc, Bui Quang, Ouedraogo, Alphonse, Ramharter, Michael

Volltext

Tetrahydro-2-naphthyl and 2‑Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity von Kokkonda, Sreekanth, Deng, Xiaoyi, White, Karen L, Coteron, Jose M, Marco, Maria, de las Heras, Laura, White, John, El Mazouni, Farah, Tomchick, Diana R, Manjalanagara, Krishne, Rudra, Kakali Rani, Chen, Gong, Morizzi, Julia, Ryan, Eileen, Kaminsky, Werner, Leroy, Didier, Martínez-Martínez, María Santos, Jimenez-Diaz, Maria Belen, Bazaga, Santiago Ferrer, Angulo-Barturen, Iñigo, Waterson, David, Burrows, Jeremy N, Matthews, Dave, Charman, Susan A, Phillips, Margaret A, Rathod, Pradipsinh K

Volltext

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro von Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio

Volltext

Mouse Model of Respiratory Tract Infection Induced by Waddlia chondrophila von Pilloux, Ludovic, LeRoy, Didier, Brunel, Christophe, Roger, Thierry, Greub, Gilbert

Volltext