Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma von Hansen, Joshua D, Correa, Matthew, Nagy, Mark A, Alexander, Matt, Plantevin, Veronique, Grant, Virginia, Whitefield, Brandon, Huang, Dehua, Kercher, Timothy, Harris, Roy, Narla, Rama Krishna, Leisten, Jim, Tang, Yang, Moghaddam, Mehran, Ebinger, Katalin, Piccotti, Joseph, Havens, Courtney G, Cathers, Brian, Carmichael, James, Daniel, Thomas, Vessey, Rupert, Hamann, Lawrence G, Leftheris, Katerina, Mendy, Derek, Baculi, Frans, LeBrun, Laurie A, Khambatta, Gody, Lopez-Girona, Antonia

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CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia von Hansen, Joshua D, Correa, Matthew, Alexander, Matt, Nagy, Mark, Huang, Dehua, Sapienza, John, Lu, Gang, LeBrun, Laurie A, Cathers, Brian E, Zhang, Weihong, Tang, Yang, Ammirante, Massimo, Narla, Rama K, Piccotti, Joseph R, Pourdehnad, Michael, Lopez-Girona, Antonia

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Autocatalytic Mechanism and Consequences of Covalent Heme Attachment in the Cytochrome P4504A Family von LeBrun, Laurie A., Hoch, Ute, Ortiz de Montellano, Paul R.

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase von RUEBSAM, Frank, MURPHY, Douglas E, BLAZEL, Julie K, SUN HEE KIM, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, WEBBER, Stephen E, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, THOMPSON, Peggy A, LEBRUN, Laurie A, HOU, Huiying J, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KHANDURINA, Julia, BROOKS, Jennifer, LI, Lian-Sheng, OKAMOTO, Ellen, KIRKOVSKY, Leo, JINGJING ZHAO, DRAGOVICH, Peter S, MCGUIRE, Helen M, XIANG, Alan X, ZHONGXIANG SUN, AYIDA, Benjamin K

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Participation of Histidine-51 in Catalysis by Horse Liver Alcohol Dehydrogenase von LeBrun, Laurie A, Park, Doo-Hong, Ramaswamy, S, Plapp, Bryce V

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Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase von Ruebsam, Frank, Webber, Stephen E., Tran, Martin T., Tran, Chinh V., Murphy, Douglas E., Zhao, Jingjing, Dragovich, Peter S., Kim, Sun Hee, Li, Lian-Sheng, Zhou, Yuefen, Han, Qing, Kissinger, Charles R., Showalter, Richard E., Lardy, Matthew, Shah, Amit M., Tsan, Mei, Patel, Rupal, LeBrun, Laurie A., Kamran, Ruhi, Sergeeva, Maria V., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Kirkovsky, Leo

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimizat... von Li, Lian-Sheng, Zhou, Yuefen, Murphy, Douglas E, Stankovic, Nebojsa, Zhao, Jingjing, Dragovich, Peter S, Bertolini, Thomas, Sun, Zhongxiang, Ayida, Benjamin, Tran, Chinh V, Ruebsam, Frank, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Showalter, Richard E, Patel, Rupal, Lebrun, Laurie A, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kamran, Ruhi, Brooks, Jennifer, Sergeeva, Maria V, Kirkovsky, Leo, Zhao, Qiang, Kissinger, Charles R

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazin... von DRAGOVICH, Peter S, BLAZEL, Julie K, PATEL, Rupal A, RUEBSAM, Frank, SERGEEVA, Maria V, SHAH, Amit M, SHOWALTER, Richard E, TRAN, Chinh V, TSAN, Mei, WEBBER, Stephen E, KIRKOVSKY, Leo, YUEFEN ZHOU, ELLIS, David A, QING HAN, KAMRAN, Ruhi, KISSINGER, Charles R, LEBRUN, Laurie A, LI, Lian-Sheng, MURPHY, Douglas E, NOBLE, Michael

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B po... von Kim, Sun Hee, Tran, Martin T., Ruebsam, Frank, Xiang, Alan X., Ayida, Benjamin, McGuire, Helen, Ellis, David, Blazel, Julie, Tran, Chinh V., Murphy, Douglas E., Webber, Stephen E., Zhou, Yuefen, Shah, Amit M., Tsan, Mei, Showalter, Richard E., Patel, Rupal, Gobbi, Alberto, LeBrun, Laurie A., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Sergeeva, Maria V., Kirkovsky, Leo, Zhao, Qiang, Han, Qing, Kissinger, Charles R.

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The P450cam G248E Mutant Covalently Binds Its Prosthetic Heme Group von LIMBURG, Julian, LEBRUN, Laurie A., ORTIZ DE MONTELLANO, Paul R.

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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase von Ruebsam, Frank, Tran, Chinh V, Li, Lian-Sheng, Kim, Sun Hee, Xiang, Alan X, Zhou, Yuefen, Blazel, Julie K, Sun, Zhongxiang, Dragovich, Peter S, Zhao, Jingjing, McGuire, Helen M, Murphy, Douglas E, Tran, Martin T, Stankovic, Nebojsa, Ellis, David A, Gobbi, Alberto, Showalter, Richard E, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Patel, Rupal A, Lebrun, Laurie A, Hou, Huiying J, Kamran, Ruhi, Sergeeva, Maria V, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kirkovsky, Leo

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'- dihydro-1' lambda super(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H- pyridazin-3-ones: Part 4. Optimiza... von Sergeeva, Maria V, Zhou, Yuefen, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Okamoto, Ellen, Kirkovsky, Leo, Kamran, Ruhi, LeBrun, Laurie A, Tsan, Mei, Patel, Rupal, Shah, Amit M, Lardy, Matthew, Gobbi, Alberto, Li, Lian-Sheng, Zhao, Jingjing, Bertolini, Thomas, Stankovic, Nebojsa, Sun, Zhongxiang, Murphy, Douglas E, Webber, Stephen E, Dragovich, Peter S

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Interaction of the N-Terminal Domain of Apolipoprotein E4 with Heparin von Dong, Jun, Peters-Libeu, Clare A, Weisgraber, Karl H, Segelke, Brent W, Rupp, Bernhard, Capila, Ishan, Hernáiz, Maria J, LeBrun, Laurie A, Linhardt, Robert J

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5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase von ELLIS, David A, BLAZEL, Julie K, WEBBER, Stephen E, QIANG ZHAO, QING HAN, KISSINGER, Charles R, LARDY, Matthew, GOBBI, Alberto, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, LEBRUN, Laurie A, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, RUEBSAM, Frank, MURPHY, Douglas E, LI, Lian-Sheng, JINGJING ZHAO, YUEFEN ZHOU, MCGUIRE, Helen M, XIANG, Alan X

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Hexahydro-pyrrolo-and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase von RUEBSAM, Frank, ZHONGXIANG SUN, PATEL, Rupal, LEBRUN, Laurie A, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KIRKOVSKY, Leo, AYIDA, Benjamin K, WEBBER, Stephen E, YUEFEN ZHOU, QIANG ZHAO, KISSINGER, Charles R, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei

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Direct Measurement of the Interactions of Glycosaminoglycans and a Heparin Decasaccharide with the Malaria Circumsporozoite Protein von Rathore, Dharmendar, McCutchan, Thomas F, Garboczi, David N, Toida, Toshihiko, Hernáiz, Maria J, LeBrun, Laurie A, Lang, Sybil C, Linhardt, Robert J

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1 '4'-dihydro-1λ-benzo[1',2',4']thiadiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK proper... von SERGEEVA, Maria V, YUEFEN ZHOU, PATEL, Rupal, SHAH, Amit M, LARDY, Matthew, GOBBI, Alberto, LI, Lian-Sheng, JINGJING ZHAO, BERTOLINI, Thomas, STANKOVIC, Nebojsa, ZHONGXIANG SUN, MURPHY, Douglas E, BARTKOWSKI, Darian M, WEBBER, Stephen E, DRAGOVICH, Peter S, NOLAN, Thomas G, NORRIS, Daniel A, OKAMOTO, Ellen, KIRKOVSKY, Leo, KAMRAN, Ruhi, LEBRUN, Laurie A, TSAN, Mei

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4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase von ELLIS, David A, BLAZEL, Julie K, LI, Lian-Sheng, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, SHOWALTER, Richard E, LARDY, Matthew, SHAH, Amit M, TSAN, Mei, PATEL, Rupal, LEBRUN, Laurie A, WEBBER, Stephen E, KAMRAN, Ruhi, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, SERGEEVA, Maria V, KIRKOVSKY, Leo, TRAN, Chinh V, DRAGOVICH, Peter S, ZHONGXIANG SUN, RUEBSAM, Frank, MCGUIRE, Helen M, XIANG, Alan X, JINGJING ZHAO

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Covalent Attachment of the Heme Prosthetic Group in the CYP4F Cytochrome P450 Family von LeBrun, Laurie A, Xu, Fengyun, Kroetz, Deanna L, Ortiz de Montellano, Paul R

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Control of Coenzyme Binding to Horse Liver Alcohol Dehydrogenase von LeBrun, Laurie A, Plapp, Bryce V

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