Ex Vivo Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy von Karekla, Ellie, Liao, Wen-Jing, Sharp, Barry, Pugh, John, Reid, Helen, Quesne, John Le, Moore, David, Pritchard, Catrin, MacFarlane, Marion, Pringle, James Howard

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eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes von Waldron, Joseph A, Raza, Farheen, Le Quesne, John

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Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment von Zhang, Min, Luo, Jin-Li, Sun, Qianqian, Harber, James, Dawson, Alan G., Nakas, Apostolos, Busacca, Sara, Sharkey, Annabel J., Waller, David, Sheaff, Michael T., Richards, Cathy, Wells-Jordan, Peter, Gaba, Aarti, Poile, Charlotte, Baitei, Essa Y., Bzura, Aleksandra, Dzialo, Joanna, Jama, Maymun, Le Quesne, John, Bajaj, Amrita, Martinson, Luke, Shaw, Jacqui A., Pritchard, Catrin, Kamata, Tamihiro, Kuse, Nathaniel, Brannan, Lee, De Philip Zhang, Pan, Yang, Hongji, Griffiths, Gareth, Wilson, Gareth, Swanton, Charles, Dudbridge, Frank, Hollox, Edward J., Fennell, Dean A.

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The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer von Ghaddar, Nour, Wang, Shuo, Woodvine, Bethany, Krishnamoorthy, Jothilatha, van Hoef, Vincent, Darini, Cedric, Kazimierczak, Urszula, Ah-son, Nicolas, Popper, Helmuth, Johnson, Myriam, Officer, Leah, Teodósio, Ana, Broggini, Massimo, Mann, Koren K., Hatzoglou, Maria, Topisirovic, Ivan, Larsson, Ola, Le Quesne, John, Koromilas, Antonis E.

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The pathogenesis of mesothelioma is driven by a dysregulated translatome von Grosso, Stefano, Marini, Alberto, Gyuraszova, Katarina, Voorde, Johan Vande, Sfakianos, Aristeidis, Garland, Gavin D., Tenor, Angela Rubio, Mordue, Ryan, Chernova, Tanya, Morone, Nobu, Sereno, Marco, Smith, Claire P., Officer, Leah, Farahmand, Pooyeh, Rooney, Claire, Sumpton, David, Das, Madhumita, Teodósio, Ana, Ficken, Catherine, Martin, Maria Guerra, Spriggs, Ruth V., Sun, Xiao-Ming, Bushell, Martin, Sansom, Owen J., Murphy, Daniel, MacFarlane, Marion, Le Quesne, John P. C., Willis, Anne E.

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Dysregulation of protein synthesis and disease von Le Quesne, John PC, Spriggs, Keith A, Bushell, Martin, Willis, Anne E

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In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth—a clinically relevant distinction von Moore, David Allan, Sereno, Marco, Das, Madhumita, Baena Acevedo, Juvenal Dario, Sinnadurai, Samantha, Smith, Claire, McSweeney, Abi, Su, Xiaoyu, Officer, Leah, Jones, Carolyn, Dudek, Kate, Guttery, David, Taniere, Phillipe, Spriggs, Ruth V., Le Quesne, John

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Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane von Phatak, Vinaya, von Grabowiecki, Yannick, Janus, Justyna, Officer, Leah, Behan, Caron, Aschauer, Lydia, Pinon, Lucia, Mackay, Hannah, Zanivan, Sara, Norman, Jim C., Kelly, Michael, Le Quesne, John, Muller, Patricia A. J.

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Repositioning PARP inhibitors for SARS‐CoV‐2 infection(COVID‐19); a new multi‐pronged therapy for acute respiratory distress syndrome? von Curtin, Nicola, Bányai, Krisztián, Thaventhiran, James, Le Quesne, John, Helyes, Zsuzsanna, Bai, Péter

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Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression von Busacca, Sara, Zhang, Qi, Sharkey, Annabel, Dawson, Alan G., Moore, David A., Waller, David A., Nakas, Apostolos, Jones, Carolyn, Cain, Kelvin, Luo, Jin-li, Salcedo, Adriana, Salaroglio, Iris Chiara, Riganti, Chiara, Le Quesne, John, John, Tom, Boutros, Paul C., Zhang, Shu-Dong, Fennell, Dean A.

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Author Correction: Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment von Zhang, Min, Luo, Jin-Li, Sun, Qianqian, Harber, James, Dawson, Alan G., Nakas, Apostolos, Busacca, Sara, Sharkey, Annabel J., Waller, David, Sheaff, Michael T., Richards, Cathy, Wells-Jordan, Peter, Gaba, Aarti, Poile, Charlotte, Baitei, Essa Y., Bzura, Aleksandra, Dzialo, Joanna, Jama, Maymun, Le Quesne, John, Bajaj, Amrita, Martinson, Luke, Shaw, Jacqui A., Pritchard, Catrin, Kamata, Tamihiro, Kuse, Nathaniel, Brannan, Lee, De Philip Zhang, Pan, Yang, Hongji, Griffiths, Gareth, Wilson, Gareth, Swanton, Charles, Dudbridge, Frank, Hollox, Edward J., Fennell, Dean A.

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Tracking the Evolution of Non–Small-Cell Lung Cancer von Jamal-Hanjani, Mariam, Wilson, Gareth A, McGranahan, Nicholas, Birkbak, Nicolai J, Watkins, Thomas B.K, Veeriah, Selvaraju, Shafi, Seema, Johnson, Diana H, Mitter, Richard, Rosenthal, Rachel, Salm, Max, Horswell, Stuart, Escudero, Mickael, Matthews, Nik, Rowan, Andrew, Chambers, Tim, Moore, David A, Turajlic, Samra, Xu, Hang, Lee, Siow-Ming, Forster, Martin D, Ahmad, Tanya, Hiley, Crispin T, Abbosh, Christopher, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M, Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Shah, Rajesh, Joseph, Leena, Quinn, Anne M, Crosbie, Phil A, Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A, Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Dentro, Stefan, Taniere, Philippe, O’Sullivan, Brendan, Lowe, Helen L, Hartley, John A, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Shaw, Jacqui A, Herrero, Javier, Szallasi, Zoltan, Schwarz, Roland F, Stewart, Aengus, Quezada, Sergio A, Le Quesne, John, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Swanton, Charles

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells von Kolluri, Krishna Kalyan, Alifrangis, Constantine, Kumar, Neelam, Ishii, Yuki, Price, Stacey, Michaut, Magali, Williams, Steven, Barthorpe, Syd, Lightfoot, Howard, Busacca, Sara, Sharkey, Annabel, Yuan, Zhenqiang, Sage, Elizabeth K, Vallath, Sabarinath, Le Quesne, John, Tice, David A, Alrifai, Doraid, von Karstedt, Sylvia, Montinaro, Antonella, Guppy, Naomi, Waller, David A, Nakas, Apostolos, Good, Robert, Holmes, Alan, Walczak, Henning, Fennell, Dean A, Garnett, Mathew, Iorio, Francesco, Wessels, Lodewyk, McDermott, Ultan, Janes, Samuel M

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Geospatial immune variability illuminates differential evolution of lung adenocarcinoma von AbdulJabbar, Khalid, Raza, Shan E. Ahmed, Rosenthal, Rachel, Jamal-Hanjani, Mariam, Veeriah, Selvaraju, Akarca, Ayse, Lund, Tom, Moore, David A., Salgado, Roberto, Al Bakir, Maise, Zapata, Luis, Hiley, Crispin T., Officer, Leah, Sereno, Marco, Smith, Claire Rachel, Loi, Sherene, Hackshaw, Allan, Marafioti, Teresa, Quezada, Sergio A., McGranahan, Nicholas, Le Quesne, John, Swanton, Charles, Yuan, Yinyin

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Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma von Au, Lewis, Hatipoglu, Emine, Litchfield, Kevin, Beattie, Gordon, Horswell, Stuart, Nicol, David, Mason, Robert, Del Rosario, Lyra, Edmonds, Kim, Lingard, Karla, Sarker, Sarah, Carlyle, Eleanor, Attig, Jan, Becker, Pablo D., Puccio, Ignazio, Lund, Tom, Ghorani, Ehsan, Xu, Hang, Mitchison, Miriam, Moore, David A., Proctor, Ian, Falzon, Mary, Furness, Andrew J.S., Reading, James L., Marafioti, Teresa, Abbosh, Chris, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Enfield, Katey, Huebner, Ariana, Enver, Tariq, Sinclair, Ron, Rhodes, Zoe, Moore, David, Khiroya, Reena, Ellery, Peter, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Akther, Mita Afroza, Naceur-Lombardelli, Cristina, Manzano, Lizi, Summan, Simranpreet, Kanu, Nnenna, Ward, Sophie, Stone, Paddy, Stirling, Caroline, Spain, Lavinia, Shum, Ben, Carlyle, Eleanor, Korteweg, Justine, Chandra, Ashish, Stewart, Ruby, Iredale, Lara-Rose, Enting, Debra, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Caldas, Carlos, Fitzgerald, Rebecca, Provenzano, Elena, Cluroe, Alison, McDermott, Ultan, Tavare, Simon, Roxburgh, Patricia, Chalmers, Anthony, Fraser, Sioban, Oien, Karin, Krebs, Matt, Blackhall, Fiona, Dransfield, Jo, Le Quesne, John, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Kerr, Amy, Middleton, Gary, Webb, Joanne, Ottensmeier, Christian, Harrison, David, Hackshaw, Allan, Ledermann, Jonathan, Sharp, Abby, Farrelly, Laura, Bridger, Hayley, Kassiotis, George, Chain, Benny, Larkin, James, Swanton, Charles, Quezada, Sergio A., Turajlic, Samra, Drake, William, Fernando, Archana, Hazell, Steve, Hill, Peter, O'Brien, Tim

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Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry von Mitchell, Sally A, Spriggs, Keith A, Bushell, Martin, Evans, Joanne R, Stoneley, Mark, Le Quesne, John P C, Spriggs, Ruth V, Willis, Anne E

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The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers in breast cancer clinical trials a... von Gonzalez‐Ericsson, Paula I, Stovgaard, Elisabeth S, Sua, Luz F, Reisenbichler, Emily, Kos, Zuzana, Carter, Jodi M, Michiels, Stefan, Le Quesne, John, Nielsen, Torsten O, Lænkholm, Anne‐Vibeke, Fox, Stephen B, Adam, Julien, Bartlett, John MS, Rimm, David L, Quinn, Cecily, Peeters, Dieter, Dieci, Maria V, Vincent‐Salomon, Anne, Cree, Ian, Hida, Akira I, Balko, Justin M, Haynes, Harry R, Frahm, Isabel, Acosta‐Haab, Gabriela, Balancin, Marcelo, Bellolio, Enrique, Yang, Wentao, Kirtani, Pawan, Sugie, Tomoharu, Ehinger, Anna, Castaneda, Carlos A, Kok, Marleen, McArthur, Heather, Siziopikou, Kalliopi, Badve, Sunil, Fineberg, Susan, Gown, Allen, Viale, Giuseppe, Schnitt, Stuart J, Pruneri, Giancarlo, Penault‐Llorca, Frederique, Hewitt, Stephen, Thompson, E Aubrey, Allison, Kimberly H, Symmans, William F, Bellizzi, Andrew M, Brogi, Edi, Moore, David A, Larsimont, Denis, Dillon, Deborah A, Lazar, Alexander, Lien, Huangchun, Goetz, Matthew P, Broeckx, Glenn, El Bairi, Khalid, Harbeck, Nadia, Cimino‐Mathews, Ashley, Sotiriou, Christos, Adams, Sylvia, Liu, Shi‐wei, Loibl, Sibylle, Chen, I‐Chun, Lakhani, Sunil R, Juco, Jonathan W, Denkert, Carsten, Blackley, Elizabeth F, Demaria, Sandra, Leon‐Ferre, Roberto, Gluz, Oleg, Zardavas, Dimitrios, Emancipator, Kenneth, Ely, Scott, Loi, Sherene, Salgado, Roberto, Sanders, Melinda

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Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease von Hiley, Crispin T, MD, Le Quesne, John, FRCPath, Santis, George, Prof, Sharpe, Rowena, PhD, de Castro, David Gonzalez, Prof, Middleton, Gary, Prof, Swanton, Charles, Prof

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MicroRNA In Situ Hybridization in Tissue Microarrays von Turnock-Jones, Julia J., Le Quesne, John P. C.

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Micro-RNAs and breast cancer von Le Quesne, John, Caldas, Carlos

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