Clinical pharmacology as a cornerstone of orphan drug development von Bashaw, Edward D., Huang, Shiew-Mei, Coté, Timothy R., Pariser, Anne R., Garnett, Christine E., Burckart, Gilbert, Zhang, Lei, Men, Angela Y., Le, Christine D., Charlab, Rosane, Gobburu, Jogaro V., Lesko, Lawrence J.

Volltext

Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation von Mingueneau, Michael, PhD, Boudaoud, Saida, MSc, Haskett, Scott, MSc, Reynolds, Taylor L., DVM, PhD, Nocturne, Gaetane, MD, PhD, Norton, Elizabeth, BSc, Zhang, Xueli, BSc, Constant, Myrtha, BSc, Park, Daniel, MSc, Wang, Wenting, PhD, Lazure, Thierry, MD, Le Pajolec, Christine, MD, Ergun, Ayla, PhD, Mariette, Xavier, MD, PhD

Volltext

Systematic neonatal screening for severe combined immunodeficiency and severe T-cell lymphopenia: Analysis of cost-effectiveness based on French real field data von Clément, Marie Caroline, MD, Mahlaoui, Nizar, MD, MSc, MPH, Mignot, Cécile, MD, MPH, Le Bihan, Christine, MD, Rabetrano, Hasina, MSc, Hoang, Ly, MSc, Neven, Bénédicte, MD, PhD, Moshous, Despina, MD, PhD, Cavazzana, Marina, MD, PhD, Blanche, Stéphane, MD, Fischer, Alain, MD, PhD, Audrain, Marie, MD, PhD, Durand-Zaleski, Isabelle, MD, PhD

Volltext

Pazopanib or methotrexate–vinblastine combination chemotherapy in adult patients with progressive desmoid tumours (DESMOPAZ): a non-comparative, randomised, open-label, multicentre... von Toulmonde, Maud, MD, Pulido, Marina, MSc, Ray-Coquard, Isabelle, Prof, Andre, Thierry, Prof, Isambert, Nicolas, MD, Chevreau, Christine, MD, Penel, Nicolas, Prof, Bompas, Emmanuelle, MD, Saada, Esma, MD, Bertucci, François, MD, Lebbe, Celeste, MD, Le Cesne, Axel, MD, Soulie, Patrick, MD, Piperno-Neumann, Sophie, MD, Sweet, Stephen, PhD, Cecchi, Fabiola, PhD, Hembrough, Todd, PhD, Bellera, Carine, PhD, Kind, Michèle, MD, Crombe, Amandine, MD, Lucchesi, Carlo, PhD, Le Loarer, François, MD, Blay, Jean-Yves, Prof, Italiano, Antoine, Prof

Volltext

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia von Hochhaus, Andreas, Larson, Richard A, Guilhot, François, Radich, Jerald P, Branford, Susan, Hughes, Timothy P, Baccarani, Michele, Deininger, Michael W, Cervantes, Francisco, Fujihara, Satoko, Ortmann, Christine-Elke, Menssen, Hans D, Kantarjian, Hagop, O’Brien, Stephen G, Druker, Brian J

Volltext

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients von Tan, Anthony T., Linster, Martin, Tan, Chee Wah, Le Bert, Nina, Chia, Wan Ni, Kunasegaran, Kamini, Zhuang, Yan, Tham, Christine Y.L., Chia, Adeline, Smith, Gavin J.D., Young, Barnaby, Kalimuddin, Shirin, Low, Jenny G.H., Lye, David, Wang, Lin-Fa, Bertoletti, Antonio

Volltext

Safety and efficacy of regorafenib in patients with advanced soft tissue sarcoma (REGOSARC): a randomised, double-blind, placebo-controlled, phase 2 trial von Mir, Olivier, MD, Brodowicz, Thomas, MD, Italiano, Antoine, MD, Wallet, Jennifer, MSc, Blay, Jean-Yves, MD, Bertucci, François, MD, Chevreau, Christine, MD, Piperno-Neumann, Sophie, MD, Bompas, Emmanuelle, MD, Salas, Sébastien, MD, Perrin, Christophe, MD, Delcambre, Corinne, MD, Liegl-Atzwanger, Bernadette, MD, Toulmonde, Maud, MD, Dumont, Sarah, MD, Ray-Coquard, Isabelle, MD, Clisant, Stéphanie, PharmD, Taieb, Sophie, MD, Guillemet, Cécile, MD, Rios, Maria, MD, Collard, Olivier, MD, Bozec, Laurence, MD, Cupissol, Didier, MD, Saada-Bouzid, Esma, MD, Lemaignan, Christine, MD, Eisterer, Wolfgang, MD, Isambert, Nicolas, MD, Chaigneau, Loïc, MD, Cesne, Axel Le, MD, Penel, Nicolas, Dr

Volltext

An SMN-Dependent U12 Splicing Event Essential for Motor Circuit Function von Lotti, Francesco, Imlach, Wendy L., Saieva, Luciano, Beck, Erin S., Hao, Le T., Li, Darrick K., Jiao, Wei, Mentis, George Z., Beattie, Christine E., McCabe, Brian D., Pellizzoni, Livio

Volltext

European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma von Pace, Andrea, MD, Dirven, Linda, PhD, Koekkoek, Johan A F, MD, Golla, Heidrun, MD, Fleming, Jane, MD, Rudà, Roberta, MD, Marosi, Christine, MD, Rhun, Emilie Le, MD, Grant, Robin, MD, Oliver, Kathy, BA, Oberg, Ingela, MSc, Bulbeck, Helen J, PhD, Rooney, Alasdair G, MD, Henriksson, Roger, Prof, Pasman, H Roeline W, PhD, Oberndorfer, Stefan, Prof, Weller, Michael, Prof, Taphoorn, Martin J B, Prof

Volltext

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas von Weller, Michael, Prof, van den Bent, Martin, Prof, Tonn, Jörg C, Prof, Stupp, Roger, Prof, Preusser, Matthias, MD, Cohen-Jonathan-Moyal, Elizabeth, Prof, Henriksson, Roger, Prof, Rhun, Emilie Le, MD, Balana, Carmen, MD, Chinot, Olivier, Prof, Bendszus, Martin, Prof, Reijneveld, Jaap C, Prof, Dhermain, Frederick, MD, French, Pim, PhD, Marosi, Christine, MD, Watts, Colin, MD, Oberg, Ingela, Pilkington, Geoffrey, PhD, Baumert, Brigitta G, MD, Taphoorn, Martin J B, Prof, Hegi, Monika, PhD, Westphal, Manfred, Prof, Reifenberger, Guido, Prof, Soffietti, Riccardo, Prof, Wick, Wolfgang, Prof

Volltext

Large Maize (Zea mays L.) SNP Genotyping Array: Development and Germplasm Genotyping, and Genetic Mapping to Compare with the B73 Reference Genome von Ganal, Martin W, Durstewitz, Gregor, Polley, Andreas, Bérard, Aurélie, Buckler, Edward S, Charcosset, Alain, Clarke, Joseph D, Graner, Eva-Maria, Hansen, Mark, Joets, Johann, Le Paslier, Marie-Christine, McMullen, Michael D, Montalent, Pierre, Rose, Mark, Schön, Chris-Carolin, Sun, Qi, Walter, Hildrun, Martin, Olivier C, Falque, Matthieu, Lukens, Lewis

Volltext

FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum von Tram, Trinh Thi Bich, Ha, Vu Thi Ngoc, Trieu, Le Pham Tien, Ashton, Philip M, Crawford, Emily D, Thu, Do Dang Anh, Quang, Nguyen Le, Thwaites, Guy E, Walker, Timothy M, Anscombe, Catherine, Thuong, Nguyen Thuy Thuong

Volltext

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173 -activating mutations in 3 children von Frémond, Marie-Louise, MD, Rodero, Mathieu Paul, PhD, Jeremiah, Nadia, PhD, Belot, Alexandre, MD, PhD, Jeziorski, Eric, MD, Duffy, Darragh, PhD, Bessis, Didier, MD, Cros, Guilhem, MD, Rice, Gillian I., PhD, Charbit, Bruno, MSc, Hulin, Anne, PharmD, PhD, Khoudour, Nihel, MD, Caballero, Consuelo Modesto, MD, Bodemer, Christine, MD, PhD, Fabre, Monique, MD, Berteloot, Laureline, MD, Le Bourgeois, Muriel, MD, Reix, Philippe, MD, Walzer, Thierry, PhD, Moshous, Despina, MD, PhD, Blanche, Stéphane, MD, PhD, Fischer, Alain, MD, PhD, Bader-Meunier, Brigitte, MD, Rieux-Laucat, Fréderic, PhD, Crow, Yanick Joseph, MD, PhD, Neven, Bénédicte, MD, PhD

Volltext

Genetic diversity, linkage disequilibrium and power of a large grapevine (Vitis vinifera L) diversity panel newly designed for association studies von Nicolas, Stéphane D, Péros, Jean-Pierre, Lacombe, Thierry, Launay, Amandine, Le Paslier, Marie-Christine, Bérard, Aurélie, Mangin, Brigitte, Valière, Sophie, Martins, Frédéric, Le Cunff, Loïc, Laucou, Valérie, Bacilieri, Roberto, Dereeper, Alexis, Chatelet, Philippe, This, Patrice, Doligez, Agnès

Volltext

Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer von McCoach, Caroline E, Blakely, Collin M, Banks, Kimberly C, Levy, Benjamin, Chue, Ben M, Raymond, Victoria M, Le, Anh T, Lee, Christine E, Diaz, Joseph, Waqar, Saiama N, Purcell, William T, Aisner, Dara L, Davies, Kurtis D, Lanman, Richard B, Shaw, Alice T, Doebele, Robert C

Volltext

Genotyping of DNA pools identifies untapped landraces and genomic regions to develop next‐generation varieties von Arca, Mariangela, Gouesnard, Brigitte, Mary‐Huard, Tristan, Le Paslier, Marie‐Christine, Bauland, Cyril, Combes, Valérie, Madur, Delphine, Charcosset, Alain, Nicolas, Stéphane D.

Volltext

Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcin... von Guigay, Joël, Aupérin, Anne, Fayette, Jérôme, Lafond, Cédrik, Martin, Laurent, Capitain, Olivier, Cupissol, Didier, Even, Caroline, Sire, Christian, Duplomb, Sophie, Evrard, Camille, Delord, Jean-Pierre, Fraslin, Aldéric, Keilholz, Ulrich, Mesia, Ricard, BABA-HAMED, Nabil, BABIN, Emmanuel, BERA, Guillaume, BETRIAN-LAGARDE, Sarah, BLOT, Emmanuel, BOREL, Christian, BRUYAS, Amandine, CALAIS, Gilles, CARPIUC, Ioana, CHAPET, Sophie, CHATELLIER, Thierry, CHELI, Sandrine, CLATOT, Florian, COJOCARASU, Oana, COUTTE, Alexandre, DALLOZ, Pierre, DELHOMMEAU, Melissa, DE RAUCOURT, Dominique, DEBOURDEAU, Philippe, DUBOS-ARVIS, Catherine, DUCOULOMBIER, Agnès, EL KOURI, Claude, FALKOWSKI, Sabrina, FERRAND, François-Regis, GATINEAU, Michel, GERVAIS, Radj, GRAS, Louis, HASBINI, Ali, HENAULT, Stéphane, HERRERA GOMEZ, Ruth Gabriela, HUGUET, Florence, LAGRANGE, Aurélie, LE FOLL, Christine, LINOT, Benjamin, LOPEZ, Qian, MAYACHE-BADIS, Lamia, MINNE, Floriane, NEIDHARDT, Eve Marie, PAVILLET, Julien, PEYRADE, Frédéric, POINTREAU, Yohann, RAMEE, Jean-François, RAUCHE, Camille, RICHARD, Sandrine, RIZZO, Claudia, ROLLAND, Frédéric, STEFANI, Laetitia, TASSY, Louis, THERY, Jean-Christophe, TOULLEC, Clémence, TOURANI, Jean-Marc, TOUSSAINT, Philippe, VAULEON, Elodie, VIRET, Frédéric, WALER, Sabine, ATZPODIEN, Jens, FIETKAU, Rainer, GRANIZKA, Thordis, GUNTINAS-LICHINUS, Orlando, HADLER-MIKESCH, Kristina, HAHN, Dennis, INHESTERN, Johanna, KELLNER, Karolin, KLINGHAMMER, Konrad, KRONENBERGER, Roland, LUEDTKE-HECKENKAMP, Kerstin, OTREMBA, Burkhard, PIRLICH, Markus, ROTHMANN, Frank, TOMETTEN, Mareike, WOHLFARTH, Sabine, ZEBRALLA, Veit, ZIPFEL, Matthias, ADANSA KLEIN, Juan Carlos, ARRAZUBI, Virginia, CABALLERO DAROQUI, Javier, CASTELO, Beatriz, CIRAUQUI CIRAUQUI, Beatriz, GALLEGO, Oscar, IGLESIAS DOCAMPO, Lara Carmen, MARTINEZ DEL PRADO, Maria, MARTINEZ-TRUFERO, Javier, PASTOR BORGONON, Miguel, PEREZ RUIZ, Elisabeth, RUBIO CASADEVALL, Jordi

Volltext

Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium von Cook, Michael B, Barnett, Matthew J, Bock, Cathryn H, Cross, Amanda J, Goodman, Phyllis J, Goodman, Gary E, Haiman, Christopher A, Khaw, Kay-Tee, McCullough, Marjorie L, Newton, Christine C, Boutron-Ruault, Marie-Christine, Lund, Eiliv, Rutegård, Martin, Thornquist, Mark D, Spriggs, Michael, Giffen, Carol, Freedman, Neal D, Kemp, Troy, Kroenke, Candyce H, Le Marchand, Loïc, Park, Jin Young, Simon, Michael, Wilkens, Lynne R, Pinto, Ligia, Hildesheim, Allan, Campbell, Peter T

Volltext

Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform von Enquist-Newman, Maria, Faust, Ann Marie E., Bravo, Daniel D., Santos, Christine Nicole S., Raisner, Ryan M., Hanel, Arthur, Sarvabhowman, Preethi, Le, Chi, Regitsky, Drew D., Cooper, Susan R., Peereboom, Lars, Clark, Alana, Martinez, Yessica, Goldsmith, Joshua, Cho, Min Y., Donohoue, Paul D., Luo, Lily, Lamberson, Brigit, Tamrakar, Pramila, Kim, Edward J., Villari, Jeffrey L., Gill, Avinash, Tripathi, Shital A., Karamchedu, Padma, Paredes, Carlos J., Rajgarhia, Vineet, Kotlar, Hans Kristian, Bailey, Richard B., Miller, Dennis J., Ohler, Nicholas L., Swimmer, Candace, Yoshikuni, Yasuo

Volltext

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial von van der Graaf, Winette TA, Prof, Blay, Jean-Yves, Prof, Chawla, Sant P, MD, Kim, Dong-Wan, MD, Bui-Nguyen, Binh, MD, Casali, Paolo G, MD, Schöffski, Patrick, Prof, Aglietta, Massimo, MD, Staddon, Arthur P, MD, Beppu, Yasuo, MD, Le Cesne, Axel, MD, Gelderblom, Hans, Prof, Judson, Ian R, Prof, Araki, Nobuhito, MD, Ouali, Monia, MSc, Marreaud, Sandrine, MD, Hodge, Rachel, MSc, Dewji, Mohammed R, MSc, Coens, Corneel, MSc, Demetri, George D, MD, Fletcher, Christopher D, Prof, Dei Tos, Angelo Paolo, MD, Hohenberger, Peter, Prof

Volltext