Drugging Undruggable Molecular Cancer Targets von Lazo, John S, Sharlow, Elizabeth R

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Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z von Gosai, Sager J, Kwak, Joon Hyeok, Luke, Cliff J, Long, Olivia S, King, Dale E, Kovatch, Kevin J, Johnston, Paul A, Shun, Tong Ying, Lazo, John S, Perlmutter, David H, Silverman, Gary A, Pak, Stephen C

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Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer von Zimmerman, Mark W, Homanics, Gregg E, Lazo, John S

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microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells von PENG WANG, FANGDONG ZOU, XIAODONG ZHANG, HUA LI, DULAK, Austin, TOMKO, Robert J, LAZO, John S, ZHENGHE WANG, LIN ZHANG, JIAN YU

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Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations von Sharlow, Elizabeth R, Llaneza, Danielle C, Tewari, Bhanu P, Mingledorff, Garnett A, Mendelson, Anna J, Sontheimer, Harald, Bloom, George S, Lazo, John S

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The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells von Colunga Biancatelli, Ruben M L, Solopov, Pavel A, Sharlow, Elizabeth R, Lazo, John S, Marik, Paul E, Catravas, John D

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The hubris and humility of cancer pharmacology in the post immuno‐oncology era von Lazo, John S.

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Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor von Salamoun, Joseph M, McQueeney, Kelley E, Patil, Kalyani, Geib, Steven J, Sharlow, Elizabeth R, Lazo, John S, Wipf, Peter

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Low molecular weight inhibitors of Myc-Max interaction and function von XIAOYING YIN, GIAP, Christine, LAZO, John S, PROCHOWNIK, Edward V

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The Substrate Recognition Domains of the N-end Rule Pathway von Tasaki, Takafumi, Zakrzewska, Adriana, Dudgeon, Drew D., Jiang, Yonghua, Lazo, John S., Kwon, Yong Tae

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PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells von ACHIWA, Hiroyuki, LAZO, John S

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Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase von Lazo, John S, Blanco, Isabella K, Tasker, Nikhil R, Rastelli, Ettore J, Burnett, James C, Garrott, Sharon R, Hart, Duncan J, McCloud, Rebecca L, Hsu, Ku-Lung, Wipf, Peter, Sharlow, Elizabeth R

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In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization von Clausen, Dana M, Guo, Jianxia, Parise, Robert A, Beumer, Jan H, Egorin, Merrill J, Lazo, John S, Prochownik, Edward V, Eiseman, Julie L

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Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches [version 1; peer review: 2 approved] von Lazo, John S

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Improved low molecular weight Myc-Max inhibitors von Wang, Huabo, Hammoudeh, Dalia I, Follis, Ariele Viacava, Reese, Brian E, Lazo, John S, Metallo, Steven J, Prochownik, Edward V

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Potent and Selective Disruption of Protein Kinase D Functionality by a Benzoxoloazepinolone von Sharlow, Elizabeth R., Giridhar, Karthik V., LaValle, Courtney R., Chen, Jun, Leimgruber, Stephanie, Barrett, Rebecca, Bravo-Altamirano, Karla, Wipf, Peter, Lazo, John S., Wang, Q. Jane

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Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities von Vázquez Rivera, Alondra, Donald, Heather, Alaoui-El-Azher, Mounia, Skoko, John J, Lazo, John S, Parniak, Michael A, Johnston, Paul A, Sluis-Cremer, Nicolas

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The Benzo[c]phenanthridine Alkaloid, Sanguinarine, Is a Selective, Cell-active Inhibitor of Mitogen-activated Protein Kinase Phosphatase-1 von Vogt, Andreas, Tamewitz, Aletheia, Skoko, John, Sikorski, Rachel P., Giuliano, Kenneth A., Lazo, John S.

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Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production von Aguilar-Sopena, Oscar, Hernandez-Perez, Sara, Alegre-Gomez, Sergio, Castro-Sanchez, Patricia, Iglesias-Ceacero, Alba, Lazo, John S., Roda-Navarro, Pedro

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Diallyl trisulfide-induced G2-M phase cell cycle arrest in human prostate cancer cells is caused by reactive oxygen species-dependent destruction and hyperphosphorylation of Cdc25C von DONG XIAO, HERMAN-ANTOSIEWICZ, Anna, ANTOSIEWICZ, Jedrzej, HUI XIAO, BRISSON, Marni, LAZO, John S, SINGH, Shivendra V

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