Biomimetic Synthesis of (−)-Longithorone A von Layton, Mark E, Morales, Carl A, Shair, Matthew D

Volltext

Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve von Klein, Rebecca M., Layton, Mark E., Regan, Hillary, Regan, Christopher P., Li, Yuxing, Filzen, Tracey, Cato, Matt, Clements, Michelle K., Wang, Jixin, Sanoja, Raul, Greshock, Thomas J., Roecker, Anthony J., Pero, Joseph E., Kim, Ron, Burgey, Christopher, John, Christopher T., Wang, Ying-Hong, Bhandari, Neetesh, Struyk, Arie, Kraus, Richard L., Henze, Darrell A., Houghton, Andrea K.

Volltext

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts von Brnardic, Edward J., Fraley, Mark E., Garbaccio, Robert M., Layton, Mark E., Sanders, John M., Culberson, Chris, Jacobson, Marlene A., Magliaro, Brian C., Hutson, Pete H., O’Brien, Julie A., Huszar, Sarah L., Uslaner, Jason M., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Sur, Sylvie M., Hartman, George D.

Volltext

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia von Layton, Mark E., Kern, Jeffrey C., Hartingh, Timothy J., Shipe, William D., Raheem, Izzat, Kandebo, Monika, Hayes, Robert P., Huszar, Sarah, Eddins, Donnie, Ma, Bennett, Fuerst, Joy, Wollenberg, Gordon K., Li, Jing, Fritzen, Jeff, McGaughey, Georgia B., Uslaner, Jason M., Smith, Sean M., Coleman, Paul J., Cox, Christopher D.

Volltext

Analgesia and peripheral c-fiber modulation by selective Nav1.8 inhibition in rhesus von Vardigan, Joshua D, Pall, Parul S, McDevitt, Dillon S, Huang, ChienJung, Clements, Michelle K, Li, Yuxing, Kraus, Richard L, Breslin, Michael J, Bungard, Christopher J, Nemenov, Mikhail I, Klukinov, Mikhail, Burgey, Chritopher S, Layton, Mark E, Stachel, Shawn J, Lange, Henry S, Savitz, Alan T, Santarelli, Vincent P, Henze, Darrell A, Uslaner, Jason M

Volltext

Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic von Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.

Volltext

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Nav1.7 inhibitors with pain efficacy in mice von Roecker, Anthony J., Egbertson, Melissa, Jones, Kristen L.G., Gomez, Robert, Kraus, Richard L., Li, Yuxing, Koser, Amy Jo, Urban, Mark O., Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N., Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A., Sherer, Edward C., Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J., Houghton, Andrea K., Layton, Mark E.

Volltext

Synthesis of Cyclooctenones Using Intramolecular Hydroacylation von Aloise, Allen D, Layton, Mark E, Shair, Matthew D

Volltext

Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model von Pero, Joseph E., Rossi, Michael A., Lehman, Hannah D.G.F., Kelly, Michael J., Mulhearn, James J., Wolkenberg, Scott E., Cato, Matthew J., Clements, Michelle K., Daley, Christopher J., Filzen, Tracey, Finger, Eleftheria N., Gregan, Yun, Henze, Darrell A., Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L., Li, Yuxing, Liang, Annie, Majercak, John M., Panigel, Jacqueline, Urban, Mark O., Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K., Layton, Mark E.

Volltext

Synthesis of (-)-Longithorone A: Using Organic Synthesis to Probe a Proposed Biosynthesis von Morales, Carl A., Layton, Mark E., Shair, Matthew D., Nicolaou, Kyriacos C.

Volltext

Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists von Layton, Mark E., Kelly, Michael J., Rodzinak, Kevin J., Sanderson, Philip E., Young, Steven D., Bednar, Rodney A., DiLella, Anthony G., Mcdonald, Terrence P., Wang, Hao, Mosser, Scott D., Fay, John F., Cunningham, Michael E., Reiss, Duane R., Fandozzi, Christine, Trainor, Nicole, Liang, Annie, Lis, Edward V., Seabrook, Guy R., Urban, Mark O., Yergey, James, Koblan, Kenneth S.

Volltext

Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile von Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P. J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S

Volltext

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling von Alvarez, Nadine, Adam, Gregory C, Howe, John A, Sharma, Vijeta, Zimmerman, Matthew D, Dolgov, Enriko, Rasheed, Risha, Nizar, Fatima, Sahay, Khushboo, Nelson, Andrew M, Park, Steven, Zhou, Xiaoyan, Burlein, Christine, Fay, John F, Iwamoto, Daniel V, Bahnck-Teets, Carolyn M, Getty, Krista L, Lin Goh, Shih, Salhab, Imad, Smith, Keith, Boyce, Christopher W, Cabalu, Tamara D, Murgolo, Nicholas, Fox, Nicholas G, Mayhood, Todd W, Shurtleff, Valerie W, Layton, Mark E, Parish, Craig A, McCauley, John A, Olsen, David B, Perlin, David S

Volltext

Discovery of Arylsulfonamide Na v 1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile von Roecker, Anthony J, Layton, Mark E, Pero, Joseph E, Kelly, 3rd, Michael J, Greshock, Thomas J, Kraus, Richard L, Li, Yuxing, Klein, Rebecca, Clements, Michelle, Daley, Christopher, Jovanovska, Aneta, Ballard, Jeanine E, Wang, Deping, Zhao, Fuqiang, Brunskill, Andrew P J, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Houghton, Andrea K, Burgey, Christopher S

Volltext

Benzoxazolinone aryl sulfonamides as potent, selective Na v 1.7 inhibitors with in vivo efficacy in a preclinical pain model von Pero, Joseph E, Rossi, Michael A, Lehman, Hannah D G F, Kelly, 3rd, Michael J, Mulhearn, James J, Wolkenberg, Scott E, Cato, Matthew J, Clements, Michelle K, Daley, Christopher J, Filzen, Tracey, Finger, Eleftheria N, Gregan, Yun, Henze, Darrell A, Jovanovska, Aneta, Klein, Rebecca, Kraus, Richard L, Li, Yuxing, Liang, Annie, Majercak, John M, Panigel, Jacqueline, Urban, Mark O, Wang, Jixin, Wang, Ying-Hong, Houghton, Andrea K, Layton, Mark E

Volltext

Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na v 1.7 inhibitors with pain efficacy in mice von Roecker, Anthony J, Egbertson, Melissa, Jones, Kristen L G, Gomez, Robert, Kraus, Richard L, Li, Yuxing, Koser, Amy Jo, Urban, Mark O, Klein, Rebecca, Clements, Michelle, Panigel, Jacqueline, Daley, Christopher, Wang, Jixin, Finger, Eleftheria N, Majercak, John, Santarelli, Vincent, Gregan, Irene, Cato, Matthew, Filzen, Tracey, Jovanovska, Aneta, Wang, Ying-Hong, Wang, Deping, Joyce, Leo A, Sherer, Edward C, Peng, Xuanjia, Wang, Xiu, Sun, Haiyan, Coleman, Paul J, Houghton, Andrea K, Layton, Mark E

Volltext

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinic... von Layton, Mark E., Reif, Alexander J., Hartingh, Timothy J., Rodzinak, Kevin, Dudkin, Vadim, Wang, Cheng, Arrington, Ken, Kelly, Michael J., Garbaccio, Robert M., O’Brien, Julie A., Magliaro, Brian C., Uslaner, Jason M., Huszar, Sarah L., Fillgrove, Kerry L., Tang, Cuyue, Kuo, Yuhsin, Jacobson, Marlene A.

Volltext

Optimization of Novel Aza-benzimidazolone mGluR2 PAMs with Respect to LLE and PK Properties and Mitigation of CYP TDI von Pero, Joseph E, Rossi, Michael A, Kelly, Michael J, Lehman, Hannah D. G. F, Layton, Mark E, Garbaccio, Robert M, O’Brien, Julie A, Magliaro, Brian C, Uslaner, Jason M, Huszar, Sarah L, Fillgrove, Kerry L, Tang, Cuyue, Kuo, Yuhsin, Joyce, Leo A, Sherer, Edward C, Jacobson, Marlene A

Volltext

Synthesis of (+)-CP-263,114 von Chen, Chuo, Layton, Mark E, Sheehan, Scott M, Shair, Matthew D

Volltext

Stereospecific Synthesis of the CP-263,114 Core Structure von Chen, Chuo, Layton, Mark E, Shair, Matthew D

Volltext