Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor von Hallin, Jill, Bowcut, Vickie, Calinisan, Andrew, Briere, David M., Hargis, Lauren, Engstrom, Lars D., Laguer, Jade, Medwid, James, Vanderpool, Darin, Lifset, Ella, Trinh, David, Hoffman, Natalie, Wang, Xiaolun, David Lawson, J., Gunn, Robin J., Smith, Christopher R., Thomas, Nicole C., Martinson, Matthew, Bergstrom, Alex, Sullivan, Francis, Bouhana, Karyn, Winski, Shannon, He, Leo, Fernandez-Banet, Julio, Pavlicek, Adam, Haling, Jacob R., Rahbaek, Lisa, Marx, Matthew A., Olson, Peter, Christensen, James G.

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Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor von Wang, Xiaolun, Allen, Shelley, Blake, James F, Bowcut, Vickie, Briere, David M, Calinisan, Andrew, Dahlke, Joshua R, Fell, Jay B, Fischer, John P, Gunn, Robin J, Hallin, Jill, Laguer, Jade, Lawson, J. David, Medwid, James, Newhouse, Brad, Nguyen, Phong, O’Leary, Jacob M, Olson, Peter, Pajk, Spencer, Rahbaek, Lisa, Rodriguez, Mareli, Smith, Christopher R, Tang, Tony P, Thomas, Nicole C, Vanderpool, Darin, Vigers, Guy P, Christensen, James G, Marx, Matthew A

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Protein flexibility and intrinsic disorder von Radivojac, Predrag, Obradovic, Zoran, Smith, David K., Zhu, Guang, Vucetic, Slobodan, Brown, Celeste J., Lawson, J. David, Dunker, A. Keith

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MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody von Farrell, Pamela J, Matuszkiewicz, Jennifer, Balakrishna, Deepika, Pandya, Shweta, Hixon, Mark S, Kamran, Ruhi, Chu, Shaosong, Lawson, J David, Okada, Kengo, Hori, Akira, Mizutani, Akio, Iwata, Hidehisa, de Jong, Ron, Hibner, Barbara, Vincent, Patrick

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Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 2 von McBride, Christopher, Cheruvallath, Zacharia, Komandla, Mallareddy, Tang, Mingnam, Farrell, Pamela, Lawson, J. David, Vanderpool, Darin, Wu, Yiqin, Dougan, Douglas R., Plonowski, Artur, Holub, Corine, Larson, Chris

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DisProt: a database of protein disorder von Vucetic, Slobodan, Obradovic, Zoran, Vacic, Vladimir, Radivojac, Predrag, Peng, Kang, Iakoucheva, Lilia M., Cortese, Marc S., Lawson, J. David, Brown, Celeste J., Sikes, Jason G., Newton, Crystal D., Dunker, A. Keith

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Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers von Smith, Christopher R, Aranda, Ruth, Bobinski, Thomas P, Briere, David M, Burns, Aaron C, Christensen, James G, Clarine, Jeffery, Engstrom, Lars D, Gunn, Robin J, Ivetac, Anthony, Jean-Baptiste, Ronald, Ketcham, John M, Kobayashi, Masakazu, Kuehler, Jon, Kulyk, Svitlana, Lawson, J. David, Moya, Krystal, Olson, Peter, Rahbaek, Lisa, Thomas, Nicole C, Wang, Xiaolun, Waters, Laura M, Marx, Matthew A

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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction von Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.

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Selected Approaches to Disrupting Protein-Protein Interactions within the MAPK/RAS Pathway von Harwood, Stephen J, Smith, Christopher R, Lawson, J David, Ketcham, John M

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MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer von Engstrom, Lars D, Aranda, Ruth, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Trinh, David, Hebbert, Allan, Smith, Christopher R, Kulyk, Svitlana, Lawson, J David, He, Leo, Hover, Laura D, Fernandez-Banet, Julio, Hallin, Jill, Vanderpool, Darin, Briere, David M, Blaj, Alice, Marx, Matthew A, Rodon, Jordi, Offin, Michael, Arbour, Kathryn C, Johnson, Melissa L, Kwiatkowski, David J, Jänne, Pasi A, Haddox, Candace L, Papadopoulos, Kyriakos P, Henry, Jason T, Leventakos, Konstantinos, Christensen, James G, Shazer, Ronald, Olson, Peter

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Intrinsic Disorder in Cell-signaling and Cancer-associated Proteins von Iakoucheva, Lilia M., Brown, Celeste J., Lawson, J.David, Obradović, Zoran, Dunker, A.Keith

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Exploration of Cryptic Pockets Using Enhanced Sampling Along Normal Modes: A Case Study of KRAS G12D von Vithani, Neha, Zhang, She, Thompson, Jeffrey P., Patel, Lara A., Demidov, Alex, Xia, Junchao, Balaeff, Alexander, Mentes, Ahmet, Arnautova, Yelena A., Kohlmann, Anna, Lawson, J. David, Nicholls, Anthony, Skillman, A. Geoffrey, LeBard, David N.

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Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase von Smith, Christopher R., Dougan, Douglas R., Komandla, Mallareddy, Kanouni, Toufike, Knight, Beverly, Lawson, J. David, Sabat, Mark, Taylor, Ewan R., Vu, Phong, Wyrick, Corey

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Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors von Smith, Christopher R., Aranda, Ruth, Christensen, James G., Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, David Lawson, J., Marx, Matthew A., Olson, Peter, Thomas, Nicole C., Wang, Xiaolun, Waters, Laura M., Kulyk, Svitlana

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Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)‑5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro‑3H‑1,2,4-triazol-3-one, by Fra... von Sabat, Mark, Dougan, Douglas R, Knight, Beverly, Lawson, J. David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

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Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X‑Ray Cocrystallography von Smith, Christopher R., Chen, Dan, Christensen, James G., Coulombe, René, Féthière, James, Gunn, Robin J., Hollander, Johan, Jones, Benjamin, Ketcham, John M., Khare, Shilpi, Kuehler, Jon, Lawson, J. David, Marx, Matthew A., Olson, Peter, Pearson, Kelly E., Ren, Cynthia, Tsagris, Denise, Ulaganathan, Thirumalaiselvi, Van’t Veer, Inge, Wang, Xiaolun, Ivetac, Anthony

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Molecular dynamics analysis of structural factors influencing back door pi release in myosin von Lawson, J David, Pate, Edward, Rayment, Ivan, Yount, Ralph G

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Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S )-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-one, by... von Sabat, Mark, Dougan, Douglas R, Knight, Beverly, Lawson, J David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

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Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3Kα Mutant Protein von Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.

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Correction to “Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)‑5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro‑3H‑1,2,4-triazo... von Sabat, Mark, Dougan, Douglas R, Ermolieff, Jacques, Halkowycz, Petro, Knight, Beverly, Lawson, J. David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

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