A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation von XIAOLEI ZHANG, YING SUN, PIREDDU, Roberta, HUA YANG, URLAM, Murali K, LAWRENCE, Harshani R, GUIDA, Wayne C, LAWRENCE, Nicholas J, SEBTI, Saïd M

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Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer von Mahajan, Kiran, Coppola, Domenico, Rawal, Bhupendra, Chen, Y. Ann, Lawrence, Harshani R., Engelman, Robert W., Lawrence, Nicholas J., Mahajan, Nupam P.

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Regulation of Matrix Metalloproteinase Genes by E2F Transcription Factors: Rb-Raf-1 Interaction as a Novel Target for Metastatic Disease von JOHNSON, Jackie L, PILLAI, Smitha, PERNAZZA, Danielle, SEBTI, Saïd M, LAWRENCE, Nicholas J, CHELLAPPAN, Srikumar P

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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon von Akuffo, Afua A., Alontaga, Aileen Y., Metcalf, Rainer, Beatty, Matthew S., Becker, Andreas, McDaniel, Jessica M., Hesterberg, Rebecca S., Goodheart, William E., Gunawan, Steven, Ayaz, Muhammad, Yang, Yan, Karim, Md Rezaul, Orobello, Morgan E., Daniel, Kenyon, Guida, Wayne, Yoder, Jeffrey A., Rajadhyaksha, Anjali M., Schönbrunn, Ernst, Lawrence, Harshani R., Lawrence, Nicholas J., Epling-Burnette, Pearlie K.

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Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor von Chen, Liwei, Sung, Shen-Shu, Yip, M L Richard, Lawrence, Harshani R, Ren, Yuan, Guida, Wayne C, Sebti, Said M, Lawrence, Nicholas J, Wu, Jie

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Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity von Mahajan, Kiran, Challa, Sridevi, Coppola, Domenico, Lawrence, Harshani, Luo, Yunting, Gevariya, Harsukh, Zhu, Weiwei, Chen, Y. Ann, Lawrence, Nicholas J., Mahajan, Nupam P.

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Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones von Ducki, Sylvie, Mackenzie, Grant, Greedy, Ben, Armitage, Simon, Chabert, Jérémie Fournier Dit, Bennett, Elizabeth, Nettles, Jim, Snyder, James P., Lawrence, Nicholas J.

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Nicotine-mediated induction of E-selectin in aortic endothelial cells requires Src kinase and E2F1 transcriptional activity von Alamanda, Vignesh, Singh, Sandeep, Lawrence, Nicholas J., Chellappan, Srikumar P.

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Lysophosphatidic acid acyltransferase beta regulates mTOR signaling von Blaskovich, Michelle A, Yendluri, Vimala, Lawrence, Harshani R, Lawrence, Nicholas J, Sebti, Saïd M, Springett, Gregory M

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Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors von Li, Rongshi, Martin, Mathew P, Liu, Yan, Wang, Binglin, Patel, Ronil A, Zhu, Jin-Yi, Sun, Nan, Pireddu, Roberta, Lawrence, Nicholas J, Li, Jiannong, Haura, Eric B, Sung, Shen-Shu, Guida, Wayne C, Schonbrunn, Ernst, Sebti, Said M

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Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof von Davis, Ryan R, Li, Baoli, Yun, Sang Y, Chan, Alice, Nareddy, Pradeep, Gunawan, Steven, Ayaz, Muhammad, Lawrence, Harshani R, Reuther, Gary W, Lawrence, Nicholas J, Schönbrunn, Ernst

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Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation von Yang, Hua, Lawrence, Harshani R, Kazi, Aslamuzzaman, Gevariya, Harsukh, Patel, Ronil, Luo, Yunting, Rix, Uwe, Schonbrunn, Ernst, Lawrence, Nicholas J, Sebti, Said M

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ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary Tumor Oncogene HOXA1 von Mahajan, Kiran, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Nupam P.

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Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors von Karim, Rezaul Md, Bikowitz, Melissa J, Chan, Alice, Zhu, Jin-Yi, Grassie, Dylan, Becker, Andreas, Berndt, Norbert, Gunawan, Steven, Lawrence, Nicholas J, Schönbrunn, Ernst

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Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells von Mahajan, Nupam P., Coppola, Domenico, Kim, Jongphil, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Kiran

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RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer von PATEL, Ronil A, FORINASH, Kara D, PIREDDU, Roberta, YING SUN, NAN SUN, MARTIN, Mathew P, SCHÖNBRUNN, Ernst, LAWRENCE, Nicholas J, SEBTI, Saïd M

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Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity von Ducki, Sylvie, Rennison, David, Woo, Meiko, Kendall, Alexander, Chabert, Jérémie Fournier Dit, McGown, Alan T., Lawrence, Nicholas J.

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Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer von Nerlakanti, Niveditha, Yao, Jiqiang, Nguyen, Duy T, Patel, Ami K, Eroshkin, Alexey M, Lawrence, Harshani R, Ayaz, Muhammad, Kuenzi, Brent M, Agarwal, Neha, Chen, Yunyun, Gunawan, Steven, Karim, Rezaul M, Berndt, Norbert, Puskas, John, Magliocco, Anthony M, Coppola, Domenico, Dhillon, Jasreman, Zhang, Jingsong, Shymalagovindarajan, Subramaniam, Rix, Uwe, Kim, Youngchul, Perera, Ranjan, Lawrence, Nicholas J, Schonbrunn, Ernst, Mahajan, Kiran

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Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes von Hesterberg, Rebecca S., Beatty, Matthew S., Han, Ying, Fernandez, Mario R., Akuffo, Afua A., Goodheart, William E., Yang, Chunying, Chang, Shiun, Colin, Christelle M., Alontaga, Aileen Y., McDaniel, Jessica M., Mailloux, Adam W., Billington, Julia M.R., Yue, Lanzhu, Russell, Shonagh, Gillies, Robert J., Yun, Sang Y., Ayaz, Muhammad, Lawrence, Nicholas J., Lawrence, Harshani R., Yu, Xue-Zhong, Fu, Jianing, Darville, Lancia N., Koomen, John M., Ren, Xiubao, Messina, Jane, Jiang, Kun, Garrett, Timothy J., Rajadhyaksha, Anjali M., Cleveland, John L., Epling-Burnette, Pearlie K.

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Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression von Mahajan, Kiran, Coppola, Domenico, Chen, Y. Ann, Zhu, Weiwei, Lawrence, Harshani R, Lawrence, Nicholas J, Mahajan, Nupam P

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