GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors von Kazi, Aslamuzzaman, Xiang, Shengyan, Yang, Hua, Delitto, Daniel, Trevino, José, Jiang, Rays H. Y., Ayaz, Muhammad, Lawrence, Harshani R., Kennedy, Perry, Sebti, Saïd M.

Volltext

A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation von XIAOLEI ZHANG, YING SUN, PIREDDU, Roberta, HUA YANG, URLAM, Murali K, LAWRENCE, Harshani R, GUIDA, Wayne C, LAWRENCE, Nicholas J, SEBTI, Saïd M

Volltext

Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets von Knezevic, Claire E., Wright, Gabriela, Remsing Rix, Lily L., Kim, Woosuk, Kuenzi, Brent M., Luo, Yunting, Watters, January M., Koomen, John M., Haura, Eric B., Monteiro, Alvaro N., Radu, Caius, Lawrence, Harshani R., Rix, Uwe

Volltext

Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity von Li, Qingliang, Karim, Rezaul M., Cheng, Mo, Das, Mousumi, Chen, Lihong, Zhang, Chen, Lawrence, Harshani R., Daughdrill, Gary W., Schonbrunn, Ernst, Ji, Haitao, Chen, Jiandong

Volltext

Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer von Mahajan, Kiran, Coppola, Domenico, Rawal, Bhupendra, Chen, Y. Ann, Lawrence, Harshani R., Engelman, Robert W., Lawrence, Nicholas J., Mahajan, Nupam P.

Volltext

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity von Wright, Gabriela, Golubeva, Volha, Remsing Rix, Lily L, Berndt, Norbert, Luo, Yunting, Ward, Grace A, Gray, Jhanelle E, Schonbrunn, Ernst, Lawrence, Harshani R, Monteiro, Alvaro N.A, Rix, Uwe

Volltext

Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor von Chen, Liwei, Sung, Shen-Shu, Yip, M L Richard, Lawrence, Harshani R, Ren, Yuan, Guida, Wayne C, Sebti, Said M, Lawrence, Nicholas J, Wu, Jie

Volltext

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition von Phadke, Manali, Remsing Rix, Lily L., Smalley, Inna, Bryant, Annamarie T., Luo, Yunting, Lawrence, Harshani R., Schaible, Braydon J., Chen, Yian A., Rix, Uwe, Smalley, Keiran S. M.

Volltext

Lysophosphatidic acid acyltransferase beta regulates mTOR signaling von Blaskovich, Michelle A, Yendluri, Vimala, Lawrence, Harshani R, Lawrence, Nicholas J, Sebti, Saïd M, Springett, Gregory M

Volltext

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof von Davis, Ryan R, Li, Baoli, Yun, Sang Y, Chan, Alice, Nareddy, Pradeep, Gunawan, Steven, Ayaz, Muhammad, Lawrence, Harshani R, Reuther, Gary W, Lawrence, Nicholas J, Schönbrunn, Ernst

Volltext

ACK1 Tyrosine Kinase Interacts with Histone Demethylase KDM3A to Regulate the Mammary Tumor Oncogene HOXA1 von Mahajan, Kiran, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Nupam P.

Volltext

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation von Yang, Hua, Lawrence, Harshani R, Kazi, Aslamuzzaman, Gevariya, Harsukh, Patel, Ronil, Luo, Yunting, Rix, Uwe, Schonbrunn, Ernst, Lawrence, Nicholas J, Sebti, Said M

Volltext

The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors von Palve, Vinayak, Knezevic, Claire E., Bejan, Daniel S., Luo, Yunting, Li, Xueli, Novakova, Silvia, Welsh, Eric A., Fang, Bin, Kinose, Fumi, Haura, Eric B., Monteiro, Alvaro N., Koomen, John M., Cohen, Michael S., Lawrence, Harshani R., Rix, Uwe

Volltext

Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells von Mahajan, Nupam P., Coppola, Domenico, Kim, Jongphil, Lawrence, Harshani R., Lawrence, Nicholas J., Mahajan, Kiran

Volltext

Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer von Nerlakanti, Niveditha, Yao, Jiqiang, Nguyen, Duy T, Patel, Ami K, Eroshkin, Alexey M, Lawrence, Harshani R, Ayaz, Muhammad, Kuenzi, Brent M, Agarwal, Neha, Chen, Yunyun, Gunawan, Steven, Karim, Rezaul M, Berndt, Norbert, Puskas, John, Magliocco, Anthony M, Coppola, Domenico, Dhillon, Jasreman, Zhang, Jingsong, Shymalagovindarajan, Subramaniam, Rix, Uwe, Kim, Youngchul, Perera, Ranjan, Lawrence, Nicholas J, Schonbrunn, Ernst, Mahajan, Kiran

Volltext

Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets von Sumi, Natalia J., Ctortecka, Claudia, Hu, Qianqian, Bryant, Annamarie T., Fang, Bin, Remsing Rix, Lily L., Ayaz, Muhammad, Kinose, Fumi, Welsh, Eric A., Eschrich, Steven A., Lawrence, Harshani R., Koomen, John M., Haura, Eric B., Rix, Uwe

Volltext

Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes von Hesterberg, Rebecca S., Beatty, Matthew S., Han, Ying, Fernandez, Mario R., Akuffo, Afua A., Goodheart, William E., Yang, Chunying, Chang, Shiun, Colin, Christelle M., Alontaga, Aileen Y., McDaniel, Jessica M., Mailloux, Adam W., Billington, Julia M.R., Yue, Lanzhu, Russell, Shonagh, Gillies, Robert J., Yun, Sang Y., Ayaz, Muhammad, Lawrence, Nicholas J., Lawrence, Harshani R., Yu, Xue-Zhong, Fu, Jianing, Darville, Lancia N., Koomen, John M., Ren, Xiubao, Messina, Jane, Jiang, Kun, Garrett, Timothy J., Rajadhyaksha, Anjali M., Cleveland, John L., Epling-Burnette, Pearlie K.

Volltext

Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression von Mahajan, Kiran, Coppola, Domenico, Chen, Y. Ann, Zhu, Weiwei, Lawrence, Harshani R, Lawrence, Nicholas J, Mahajan, Nupam P

Volltext

Development of o‑Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase Inhibitors von Lawrence, Harshani R, Martin, Mathew P, Luo, Yunting, Pireddu, Roberta, Yang, Hua, Gevariya, Harsukh, Ozcan, Sevil, Zhu, Jin-Yi, Kendig, Robert, Rodriguez, Mercedes, Elias, Roy, Cheng, Jin Q, Sebti, Saïd M, Schonbrunn, Ernst, Lawrence, Nicholas J

Volltext

Discovery of PI-1840, a Novel Noncovalent and Rapidly Reversible Proteasome Inhibitor with Anti-tumor Activity von Kazi, Aslamuzzaman, Ozcan, Sevil, Tecleab, Awet, Sun, Ying, Lawrence, Harshani R., Sebti, Saïd M.

Volltext