Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas von Donehower, Lawrence A., Soussi, Thierry, Korkut, Anil, Liu, Yuexin, Schultz, Andre, Cardenas, Maria, Li, Xubin, Babur, Ozgun, Hsu, Teng-Kuei, Lichtarge, Olivier, Weinstein, John N., Akbani, Rehan, Wheeler, David A.

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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy von Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

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Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice von Lee, Susie, Donehower, Lawrence A, Herron, Alan J, Moore, David D, Fu, Loning

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A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement von Zhang, Yiqun, Chen, Fengju, Donehower, Lawrence A., Scheurer, Michael E., Creighton, Chad J.

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Widespread and tissue specific age-related DNA methylation changes in mice von Maegawa, Shinji, Hinkal, George, Kim, Hyun Soo, Shen, Lanlan, Zhang, Li, Zhang, Jiexin, Zhang, Nianxiang, Liang, Shoudan, Donehower, Lawrence A, Issa, Jean-Pierre J

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Notch Activation as a Driver of Osteogenic Sarcoma von Tao, Jianning, Jiang, Ming-Ming, Jiang, Lichun, Salvo, Jason S., Zeng, Huan-Chang, Dawson, Brian, Bertin, Terry K., Rao, Pulivarthi H., Chen, Rui, Donehower, Lawrence A., Gannon, Francis, Lee, Brendan H.

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Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation von Chambers, Stuart M, Shaw, Chad A, Gatza, Catherine, Fisk, C Joseph, Donehower, Lawrence A, Goodell, Margaret A

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WIP1 phosphatase as a potential therapeutic target in neuroblastoma von Richter, Mark, Dayaram, Tajhal, Gilmartin, Aidan G, Ganji, Gopinath, Pemmasani, Sandhya Kiran, Van Der Key, Harjeet, Shohet, Jason M, Donehower, Lawrence A, Kumar, Rakesh

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Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas von Donehower, Lawrence A., Soussi, Thierry, Korkut, Anil, Liu, Yuexin, Schultz, Andre, Cardenas, Maria, Li, Xubin, Babur, Ozgun, Hsu, Teng-Kuei, Lichtarge, Olivier, Weinstein, John N., Akbani, Rehan, Wheeler, David A.

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints von Lu, Xiongbin, Nannenga, Bonnie, Donehower, Lawrence A

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miR‐130b directly targets ARHGAP1 to drive activation of a metastatic CDC42‐PAK1‐AP1 positive feedback loop in Ewing sarcoma von Satterfield, Laura, Shuck, Ryan, Kurenbekova, Lyazat, Allen‐Rhoades, Wendy, Edwards, Dean, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Donehower, Lawrence A., Yustein, Jason T.

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The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways von Lu, Xiongbin, Nguyen, Thuy-Ai, Moon, Sung-Hwan, Darlington, Yolanda, Sommer, Matthias, Donehower, Lawrence A.

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Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential von Techavichit, Piti, Gao, Yang, Kurenbekova, Lyazat, Shuck, Ryan, Donehower, Lawrence A, Yustein, Jason T

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The Wip1 Phosphatase Acts as a Gatekeeper in the p53-Mdm2 Autoregulatory Loop von Lu, Xiongbin, Ma, Ou, Nguyen, Thuy-Ai, Jones, Stephen N., Oren, Moshe, Donehower, Lawrence A.

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Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression von Hinkal, George, Parikh, Neha, Donehower, Lawrence A

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Effects of TP53 mutational status on gene expression patterns across 10 human cancer types von Parikh, Neha, Hilsenbeck, Susan, Creighton, Chad J, Dayaram, Tajhal, Shuck, Ryan, Shinbrot, Eve, Xi, Liu, Gibbs, Richard A, Wheeler, David A, Donehower, Lawrence A

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Pla2g16 phospholipase mediates gain-of-function activities of mutant p53 von Xiong, Shunbin, Tu, Huolin, Kollareddy, Madhusudhan, Pant, Vinod, Li, Qin, Zhang, Yun, Jackson, James G., Suh, Young-Ah, Elizondo-Fraire, Ana C., Yang, Peirong, Chau, Gilda, Tashakori, Mehrnoosh, Wasylishen, Amanda R., Ju, Zhenlin, Solomon, Hilla, Rotter, Varda, Liu, Bin, El-Naggar, Adel K., Donehower, Lawrence A., Martinez, Luis Alfonso, Lozano, Guillermina

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The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging von Dumble, Melissa, Moore, Lynette, Chambers, Stuart M., Geiger, Hartmut, Van Zant, Gary, Goodell, Margaret A., Donehower, Lawrence A.

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K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications von Nakahata, Kengo, Simons, Brian W, Pozzo, Enrico, Shuck, Ryan, Kurenbekova, Lyazat, Prudowsky, Zachary, Dholakia, Kshiti, Coarfa, Cristian, Patel, Tajhal D, Donehower, Lawrence A, Yustein, Jason T

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MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes von Donehower, Lawrence A, Creighton, Chad J, Schultz, Nikolaus, Shinbrot, Eve, Chang, Kyle, Gunaratne, Preethi H, Muzny, Donna, Sander, Chris, Hamilton, Stanley R, Gibbs, Richard A, Wheeler, David

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