NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts von Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen D., Edwards, Dylan R., Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.

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Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment von Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D., Edwards, Dylan R., Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M., Rushworth, Stuart A.

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Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells von Montano, Monica M, Yeh, I-Ju, Chen, Yinghua, Hernandez, Chris, Kiselar, Janna G, de la Fuente, Maria, Lawes, Adriane M, Nieman, Marvin T, Kiser, Philip D, Jacobberger, James, Exner, Agata A, Lawes, Matthew C

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Structural modeling of an outer membrane electron conduit from a metal-reducing bacterium suggests electron transfer via periplasmic redox partners von Edwards, Marcus J., White, Gaye F., Lockwood, Colin W., Lawes, Matthew C., Martel, Anne, Harris, Gemma, Scott, David J., Richardson, David J., Butt, Julea N., Clarke, Thomas A.

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MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia von Abdul-Aziz, Amina M, Shafat, Manar S, Mehta, Tarang K, Di Palma, Federica, Lawes, Matthew J, Rushworth, Stuart A, Bowles, Kristian M

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Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML von Zaitseva, Lyubov, Murray, Megan Y, Shafat, Manar S, Lawes, Matthew J, MacEwan, David J, Bowles, Kristian M, Rushworth, Stuart A

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Genetic diversity and phylogeography of broomcorn millet (Panicum miliaceum L.) across Eurasia von HUNT, HARRIET V., CAMPANA, MICHAEL G., LAWES, MATTHEW C., PARK, YONG-JIN, BOWER, MIM A., HOWE, CHRISTOPHER J., JONES, MARTIN K.

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Characterization of MtoD from Sideroxydans lithotrophicus: a cytochrome c electron shuttle used in lithoautotrophic growth von Beckwith, Christopher R, Edwards, Marcus J, Lawes, Matthew, Shi, Liang, Butt, Julea N, Richardson, David J, Clarke, Thomas A

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Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia von Pillinger, Genevra, Abdul-Aziz, Amina, Zaitseva, Lyubov, Lawes, Matthew, MacEwan, David J., Bowles, Kristian M., Rushworth, Stuart A.

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Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection von Pillinger, Genevra, Loughran, Niamh V, Piddock, Rachel E, Shafat, Manar S, Zaitseva, Lyubov, Abdul-Aziz, Amina, Lawes, Matthew J, Bowles, Kristian M, Rushworth, Stuart A

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Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells von Rushworth, Stuart A, PhD, Pillinger, Genevra, Abdul-Aziz, Amina, MSc, Piddock, Rachel, BSc, Shafat, Manar S, MSc, Murray, Megan Y, PhD, Zaitseva, Lyubov, PhD, Lawes, Matthew J, MB BChir, MacEwan, David J, Prof, Bowles, Kristian M, Prof

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Oseltamivir-resistant pandemic (H1N1) 2009 in patient with impaired immune system von Hill-Cawthorne, Grant A, Schelenz, Silke, Lawes, Matthew, Dervisevic, Samir

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A banned variety was the mother of several major wine grapes von Hunt, Harriet V., Lawes, Matthew C., Bower, Mim A., Haeger, John W., Howe, Christopher J.

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The Use of Avapritinib in Advanced Systemic Mastocytosis: Report of an Open-Label Compassionate Use Program in the United Kingdom von Saunders, Christopher J., Saha, Chandan, Sriskandarajah, Priya, Cashman, Helen, Wilson, Andrew J, Lambert, Jonathan, Lawes, Matthew, Tucker, David, Green, Simone, Jain, Manish, Stables, Victoria, Addada, Juanah, Yin, Theingi, Roddie, Huw, Psaila, Bethan, Radia, Deepti H.

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Acute Myeloid Leukemia Export Mitochondria in Extracellular Vesicles Which Induces Pro-Tumoral Changes in Bone Marrow Macrophages von Moore, Jamie A, Mistry, Jayna J, Horton, Rebecca H, Hellmich, Charlotte, Pattinson, Adam, Morfakis, Adam, Sun, Yu, Lawes, Matthew, Morris, Christopher J, Haestier, Anna, Bowles, Kristian M, Rushworth, Stuart A

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Protein Kinase C-ß Dependent IL-8 Release Promotes Acute Myeloid Leukemia Blast Cell Survival in Co-Cultures with Bone Marrow Stromal Cells von Abdul-Aziz, Amina M, Shafat, Manar S, Lawes, Matthew J, Bowles, Kristian M, Rushworth, Stuart A

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Hypoxia Drives AML Proliferation in the Bone Marrow Microenvironment Via Macrophage Inhibitory Factor von Abdul-Aziz, Amina M, Shafat, Manar S, Zaitseva, Lyubov, Lawes, Matthew J, Rushworth, Stuart A, Bowles, Kristian M

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Abstract 4327: Bone marrow adipocytes drive transcriptional changes in leukemic blasts to enhance their capacity to derive energy from free fatty acid metabolism von Shafat, Manar, Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen, Edwards, Dylan, Piddock, Rachel, Abdul-Aziz, Amina, Marlein, Christopher, Fenech, Matthew, Turner, Jeremy, Lawes, Matthew, Zaitseva, Lyubov, Watkins, Johnathan, Bowles, Kristian, Rushworth, Stuart

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The BTK Inhibitor Ibrutinib Blocks SDF1/CXCR4 Mediated Migration of Acute Myeloid Leukemia Cells von Rushworth, Stuart A, Zaitseva, Lyubov, Murray, Megan Y, Lawes, Matthew J, MacEwan, David J, Bowles, Kristian M

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Mutations That Confer Resistance to 2-Deoxyglucose Reduce the Specific Activity of Hexokinase from Myxococcus xanthus von Youderian, P, Lawes, M C, Creighton, C, Cook, J C, Saier, Jr, M H

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