BCX-1812 (RWJ-270201):  Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design von Babu, Y. Sudhakar, Chand, Pooran, Bantia, Shanta, Kotian, Pravin, Dehghani, Ali, El-Kattan, Yahya, Lin, Tsu-Hsing, Hutchison, Tracy L, Elliott, Arthur J, Parker, Cynthia D, Ananth, Sandya L, Horn, LaShun L, Laver, Graeme W, Montgomery, John A

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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors von Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C

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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores von Wang, Gary T, Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

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Crystal Structure of a Bacterial Sialidase (From Salmonella typhimurium LT2) Shows the Same Fold as an Influenza Virus Neuraminidase von Crennell, Susan J., Garman, Elspeth F., Laver, W. Graeme, Vimr, Eric R., Taylor, Garry L.

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Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex von Tulip, W.R., Varghese, J.N., Laver, W.G., Webster, R.G., Colman, P.M.

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Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase von KATI, Warren M, MONTGOMERY, Debra, MARING, Clarence, STOLL, Vincent S, GIRANDA, Vincent, XIAOQI CHEN, LAVER, W. Graeme, KOHLBRENNER, William, NORBECK, Daniel W

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Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent von Atigadda, Venkatram R, Brouillette, Wayne J, Duarte, Franco, Ali, Shoukath M, Babu, Yarlagadda S, Bantia, Shanta, Chand, Pooran, Chu, Naiming, Montgomery, John A, Walsh, David A, Sudbeck, Elise A, Finley, James, Luo, Ming, Air, Gillian M, Laver, Graeme W

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Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design von Chand, Pooran, Babu, Yarlagadda S, Bantia, Shanta, Chu, Naiming, Cole, L. Brent, Kotian, Pravin L, Laver, W. Graeme, Montgomery, John A, Pathak, Ved P, Petty, Sandra L, Shrout, David P, Walsh, David A, Walsh, Gerald M

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Three-dimensional Structure of Influenza A N9 Neuraminidase and Its Complex with the Inhibitor 2-Deoxy 2,3-Dehydro- N-Acetyl Neuraminic Acid von Bossart-Whitaker, P., Carson, M., Babu, Y.S., Smith, C.D., Laver, W.G., Air, Gillian M.

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Three-dimensional structure of a complex of antibody with influenza virus neuraminidase von COLMAN, P. M, LAVER, W. G, VARGHESE, J. N, BAKER, A. T, TULLOCH, P. A, AIR, G. M, WEBSTER, R. G

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Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Anal... von Kim, Choung U, Lew, Willard, Williams, Matthew A, Liu, Hongtao, Zhang, Lijun, Swaminathan, S, Bischofberger, Norbert, Chen, Ming S, Mendel, Dirk B, Tai, Chun Y, Laver, W. Graeme, Stevens, Raymond C

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Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution von Varghese, J. N., Laver, W. G., Colman, P. M.

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Hydrophobic benzoic acids as inhibitors of influenza neuraminidase von Atigadda, Venkatram R., Brouillette, Wayne J., Duarte, Franco, Babu, Yarlagadda S., Bantia, Shanta, Chand, Pooran, Chu, Naiming, Montgomery, John A., Walsh, David A., Sudbeck, Elise, Finley, James, Air, Gillian M., Luo, Ming, Laver, Graeme W.

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Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants von Tulip, W.R., Varghese, J.N., Baker, A.T., van Donkelaar, A., Laver, W.G., Webster, R.G., Colman, P.M.

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Structure of the catalytic and antigenic sites in influenza virus neuraminidase von Colman, P. M., Varghese, J. N., Laver, W. G.

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Structure-Based Inhibitors of Influenza Virus Sialidase. A Benzoic Acid Lead with Novel Interaction von Singh, Sangeeta, Jedrzejas, Marek J, Air, Gillian M, Luo, Ming, Laver, W. Graeme, Brouillette, Wayne J

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Antibody Epitopes on the Neuraminidase of a Recent H3N2 Influenza Virus (A/Memphis/31/98) von Gulati, Upma, Hwang, Chi-Ching, Venkatramani, Lalitha, Gulati, Shelly, Stray, Stephen J, Lee, Janis T, Laver, W Graeme, Bochkarev, Alexey, Zlotnick, Adam, Air, Gillian M

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Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface von Tulip, W.R., Varghese, J.N., Webster, R.G., Laver, W.G., Colman, P.M.

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Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase von SAITO, T, TAYLOR, G, LAVER, W. G, KAWAOKA, Y, WEBSTER, R. G

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Drug Development in Space? von Laver, W. Graeme

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