Safety and efficacy of the erdafitinib (erda) intravesical delivery system, TAR-210, in patients (pts) with non–muscle-invasive bladder cancer (NMIBC) or muscle-invasive bladder ca... von Vilaseca, Antoni, Guerrero, Félix, Zainfeld, Daniel, Shore, Neal D., Rodriguez Faba, Oscar, Meijer, Richard P., Witjes, Alfred Alfred, McRee, Autumn Jackson, Kalota, Anna, Stone, Nicole L., Lauring, Josh David, Zhu, Wei, Beeharry, Neil, O'Dondi, Lang A, Jayram, Gautam

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Results from molecular analysis for therapy choice (MATCH) arm I: Taselisib for PIK3CA-mutated tumors von Krop, Ian E., Jegede, Opeyemi, Grilley-Olson, Juneko E., Lauring, Josh David, Hamilton, Stanley R., Zwiebel, James A., Li, Shuli, Rubinstein, Lawrence, Doyle, Austin, Patton, David R., Mitchell, Edith P., Arteaga, Carlos L., Conley, Barbara A., Sims, David, Harris, Lyndsay, Chen, Alice P., Flaherty, Keith

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ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients von Chu, David, Paoletti, Costanza, Gersch, Christina, VanDenBerg, Dustin A, Zabransky, Daniel J, Cochran, Rory L, Wong, Hong Yuen, Toro, Patricia Valda, Cidado, Justin, Croessmann, Sarah, Erlanger, Bracha, Cravero, Karen, Kyker-Snowman, Kelly, Button, Berry, Parsons, Heather A, Dalton, W Brian, Gillani, Riaz, Medford, Arielle, Aung, Kimberly, Tokudome, Nahomi, Chinnaiyan, Arul M, Schott, Anne, Robinson, Dan, Jacks, Karen S, Lauring, Josh, Hurley, Paula J, Hayes, Daniel F, Rae, James M, Park, Ben Ho

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HER2 missense mutations have distinct effects on oncogenic signaling and migration von Zabransky, Daniel J., Yankaskas, Christopher L., Cochran, Rory L., Wong, Hong Yuen, Croessmann, Sarah, Chu, David, Kavuri, Shyam M., Red Brewer, Monica, Rosen, D. Marc, Dalton, W. Brian, Cimino-Mathews, Ashley, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Cidado, Justin, Erlanger, Bracha, Parsons, Heather A., Manto, Kristen M., Bose, Ron, Lauring, Josh, Arteaga, Carlos L., Konstantopoulos, Konstantinos, Park, Ben Ho

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Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells von Konishi, Hiroyuki, Mohseni, Morassa, Tamaki, Akina, Garay, Joseph P, Croessmann, Sarah, Karnan, Sivasundaram, Ota, Akinobu, Wong, Hong Yuen, Konishi, Yuko, Karakas, Bedri, Tahir, Khola, Abukhdeir, Abde M, Gustin, John P, Cidado, Justin, Wang, Grace M, Cosgrove, David, Cochran, Rory, Jelovac, Danijela, Higgins, Michaela J, Arena, Sabrina, Hawkins, Lauren, Lauring, Josh, Gross, Amy L, Heaphy, Christopher M, Hosokawa, Yositaka, Gabrielson, Edward, Meeker, Alan K, Visvanathan, Kala, Argani, Pedram, Bachman, Kurtis E, Park, Ben Ho

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Individualized Molecular Analyses Guide Efforts (IMAGE): A Prospective Study of Molecular Profiling of Tissue and Blood in Metastatic Triple-Negative Breast Cancer von Parsons, Heather A, Beaver, Julia A, Cimino-Mathews, Ashley, Ali, Siraj M, Axilbund, Jennifer, Chu, David, Connolly, Roisin M, Cochran, Rory L, Croessmann, Sarah, Clark, Travis A, Gocke, Christopher D, Jeter, Stacie C, Kennedy, Mark R, Lauring, Josh, Lee, Justin, Lipson, Doron, Miller, Vincent A, Otto, Geoff A, Rosner, Gary L, Ross, Jeffrey S, Slater, Shannon, Stephens, Philip J, VanDenBerg, Dustin A, Wolff, Antonio C, Young, Lauren E, Zabransky, Daniel J, Zhang, Zhe, Zorzi, Jane, Stearns, Vered, Park, Ben H

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Detection of Cancer DNA in Plasma of Patients with Early-Stage Breast Cancer von BEAVER, Julia A, JELOVAC, Danijela, CHU, David, BURNS, Timothy, HIGGINS, Michaela J, STEARNS, Vered, JACOBS, Lisa, HABIBI, Mehran, LANGE, Julie, HURLEY, Paula J, LAURING, Josh, VANDENBERG, Dustin A, BALUKRISHNA, Sasidharan, KESSLER, Jill, JETER, Stacie, SAMUELS, Michael L, MAAR, Dianna, COPE, Leslie, CIMINO-MATHEWS, Ashley, ARGANI, Pedram, WOLFF, Antonio C, BEN HO PARK, COCHRAN, Rory L, CROESSMANN, Sarah, ZABRANSKY, Daniel J, HONG YUEN WONG, TORO, Patricia Valda, CIDADO, Justin, BLAIR, Brian G

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Knockin of mutant PIK3CA activates multiple oncogenic pathways von Gustin, John P, Karakas, Bedri, Weiss, Michele B, Abukhdeir, Abde M, Lauring, Josh, Garay, Joseph P, Cosgrove, David, Tamaki, Akina, Konishi, Hiroyuki, Konishi, Yuko, Mohseni, Morassa, Wang, Grace, Rosen, D. Marc, Denmeade, Samuel R, Higgins, Michaela J, Vitolo, Michele I, Bachman, Kurtis E, Park, Ben Ho

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Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation von Dalton, W Brian, Helmenstine, Eric, Walsh, Noel, Gondek, Lukasz P, Kelkar, Dhanashree S, Read, Abigail, Natrajan, Rachael, Christenson, Eric S, Roman, Barbara, Das, Samarjit, Zhao, Liang, Leone, Robert D, Shinn, Daniel, Groginski, Taylor, Madugundu, Anil K, Patil, Arun, Zabransky, Daniel J, Medford, Arielle, Lee, Justin, Cole, Alex J, Rosen, Marc, Thakar, Maya, Ambinder, Alexander, Donaldson, Joshua, DeZern, Amy E, Cravero, Karen, Chu, David, Madero-Marroquin, Rafael, Pandey, Akhilesh, Hurley, Paula J, Lauring, Josh, Park, Ben Ho

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Comparison of cell stabilizing blood collection tubes for circulating plasma tumor DNA von Toro, Patricia Valda, Erlanger, Bracha, Beaver, Julia A., Cochran, Rory L., VanDenBerg, Dustin A., Yakim, Elizabeth, Cravero, Karen, Chu, David, Zabransky, Daniel J., Wong, Hong Yuen, Croessmann, Sarah, Parsons, Heather, Hurley, Paula J., Lauring, Josh, Park, Ben Ho

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NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability von Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J, Chu, David, Mendonca, Janet, Sharma, Anup, Mohseni, Morassa, Rosen, D Marc, Scharpf, Robert B, Cidado, Justin, Cochran, Rory L, Parsons, Heather A, Dalton, W Brian, Erlanger, Bracha, Button, Berry, Cravero, Karen, Kyker-Snowman, Kelly, Beaver, Julia A, Kachhap, Sushant, Hurley, Paula J, Lauring, Josh, Park, Ben Ho

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Phase 1 study of JNJ-64619178, a protein arginine methyltransferase 5 inhibitor, in patients with lower-risk myelodysplastic syndromes von Haque, Tamanna, Cadenas, Felix López, Xicoy, Blanca, Alfonso-Pierola, Ana, Platzbecker, Uwe, Avivi, Irit, Brunner, Andrew M., Chromik, Jöerg, Morillo, Daniel, Patel, Manish R., Falantes, Jose, Leitch, Heather A., Germing, Ulrich, Preis, Meir, Lenox, Laurie, Lauring, Josh, Brown, Regina J., Kalota, Anna, Mehta, Jaydeep, Pastore, Friederike, Gu, Junchen, Mistry, Pankaj, Valcárcel, David

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Phase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Patients with Lower-Risk Myelodysplastic Syndromes von Haque, Tamanna, Cadenas, Felix López, Xicoy, Blanca, Alfonso, Ana, Platzbecker, Uwe, Avivi, Irit, Brunner, Andrew M., Chromik, Jörg, Morillo, Daniel, Patel, Manish R., Falantes, José F., Leitch, Heather A., Germing, Ulrich, Preis, Meir, Lavie, David, Lenox, Laurie, Lauring, Josh, Kalota, Anna, Brown, Regina, Mehta, Jaydeep, Pastore, Friederike, Mistry, Pankaj, Valcarcel, David

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Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations von Lauring, J, Cosgrove, D P, Fontana, S, Gustin, J P, Konishi, H, Abukhdeir, A M, Garay, J P, Mohseni, M, Wang, G M, Higgins, M J, Gorkin, D, Reis, M, Vogelstein, B, Polyak, K, Cowherd, M, Buckhaults, P J, Park, B H

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Abstract 1408: SF3B1 mutations induce proteome remodeling, metabolic reprogramming, and a novel kind of tumor surface antigen in human cells von Dalton, William B., Shinn, Daniel, Walsh, Noel, Christenson, Eric, Groginski, Taylor, Kelkar, Dhanashree, Magugundu, Anil, Patil, Arun, Zabransky, Daniel, Medford, Arielle, Lee, Justin, Cole, Alex, Donaldson, Josh, DeZern, Amy, Cravero, Karen, Chu, David, Hunter, Natasha, Pandey, Akhilesh, Lauring, Josh, Park, Ben

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Ki-67 is required for maintenance of cancer stem cells but not cell proliferation von Cidado, Justin, Wong, Hong Yuen, Rosen, D Marc, Cimino-Mathews, Ashley, Garay, Joseph P, Fessler, Abigail G, Rasheed, Zeshaan A, Hicks, Jessica, Cochran, Rory L, Croessmann, Sarah, Zabransky, Daniel J, Mohseni, Morassa, Beaver, Julia A, Chu, David, Cravero, Karen, Christenson, Eric S, Medford, Arielle, Mattox, Austin, De Marzo, Angelo M, Argani, Pedram, Chawla, Ajay, Hurley, Paula J, Lauring, Josh, Park, Ben Ho

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PIK3CA mutations and TP53 alterations cooperate to increase cancerous phenotypes and tumor heterogeneity von Croessmann, Sarah, Wong, Hong Yuen, Zabransky, Daniel J., Chu, David, Rosen, D. Marc, Cidado, Justin, Cochran, Rory L., Dalton, W. Brian, Erlanger, Bracha, Cravero, Karen, Button, Berry, Kyker-Snowman, Kelly, Hurley, Paula J., Lauring, Josh, Park, Ben Ho

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Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes von Cochran, Rory L, Cidado, Justin, Kim, Minsoo, Zabransky, Daniel J, Croessmann, Sarah, Chu, David, Wong, Hong Yuen, Beaver, Julia A, Cravero, Karen, Erlanger, Bracha, Parsons, Heather, Heaphy, Christopher M, Meeker, Alan K, Lauring, Josh, Park, Ben Ho

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TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer von Wong, Hong Yuen, Wang, Grace M, Croessmann, Sarah, Zabransky, Daniel J, Chu, David, Garay, Joseph P, Cidado, Justin, Cochran, Rory L, Beaver, Julia A, Aggarwal, Anita, Liu, Min-Ling, Argani, Pedram, Meeker, Alan, Hurley, Paula J, Lauring, Josh, Park, Ben Ho

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PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells von Higgins, Michaela J., Beaver, Julia A., Wong, Hong Yuen, Gustin, John P., Lauring, Josh D., Garay, Joseph P., Konishi, Hiroyuki, Mohseni, Morassa, Wang, Grace M., Cidado, Justin, Jelovac, Danijela, Cosgrove, David P., Tamaki, Akina, Abukhdeir, Abde M., Park, Ben Ho

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