Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)­isoxazol-4-yl]methoxy}­piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dysli... von Genin, Michael J, Bueno, Ana B, Agejas Francisco, Javier, Manninen, Peter R, Bocchinfuso, Wayne P, Montrose-Rafizadeh, Chahrzad, Cannady, Ellen A, Jones, Timothy M, Stille, John R, Raddad, Eyas, Reidy, Charles, Cox, Amy, Michael, M. Dodson, Michael, Laura F

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Concordant changes of plasma and kidney microRNA in the early stages of acute kidney injury: time course in a mouse model of bilateral renal ischemia-reperfusion von Bellinger, Melissa A, Bean, James S, Rader, Melissa A, Heinz-Taheny, Kathleen M, Nunes, Jairo S, Haas, Joseph V, Michael, Laura F, Rekhter, Mark D

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Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway[S] von Blackburn, Nicholas B., Michael, Laura F., Meikle, Peter J., Peralta, Juan M., Mosior, Marian, McAhren, Scott, Bui, Hai H., Bellinger, Melissa A., Giles, Corey, Kumar, Satish, Leandro, Ana C., Almeida, Marcio, Weir, Jacquelyn M., Mahaney, Michael C., Dyer, Thomas D., Almasy, Laura, VandeBerg, John L., Williams-Blangero, Sarah, Glahn, David C., Duggirala, Ravindranath, Kowala, Mark, Blangero, John, Curran, Joanne E.

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Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor von Stayrook, Keith R, Bramlett, Kelli S, Savkur, Rajesh S, Ficorilli, James, Cook, Todd, Christe, Michael E, Michael, Laura F, Burris, Thomas P

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Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial von Nicholls, Stephen J, Nissen, Steven E, Fleming, Cynthia, Urva, Shweta, Suico, Jeffrey, Berg, Paul H, Linnebjerg, Helle, Ruotolo, Giacomo, Turner, P. Kellie, Michael, Laura F

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Lepodisiran, an Extended-Duration Short Interfering RNA Targeting Lipoprotein(a): A Randomized Dose-Ascending Clinical Trial von Nissen, Steven E, Linnebjerg, Helle, Shen, Xi, Wolski, Kathy, Ma, Xiaosu, Lim, Shufen, Michael, Laura F, Ruotolo, Giacomo, Gribble, Grace, Navar, Ann Marie, Nicholls, Stephen J

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Restoration of Insulin-Sensitive Glucose Transporter (GLUT4) Gene Expression in Muscle Cells by the Transcriptional Coactivator PGC-1 von Michael, Laura F., Wu, Zhidan, Cheatham, R. Bentley, Puigserver, Pere, Adelmant, Guillaume, Lehman, John J., Kelly, Daniel P., Spiegelman, Bruce M.

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Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals von Leandro, Ana Cristina, Michael, Laura F, Almeida, Marcio, Kuokkanen, Mikko, Huynh, Kevin, Giles, Corey, Duong, Thy, Diego, Vincent P, Duggirala, Ravindranath, Clarke, Geoffrey D, Blangero, John, Meikle, Peter J, Curran, Joanne E

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Farnesoid X Receptor Agonist Reduces Serum Asymmetric Dimethylarginine Levels through Hepatic Dimethylarginine Dimethylaminohydrolase-1 Gene Regulation von Hu, Tonghuan, Chouinard, Michael, Cox, Amy L., Sipes, Philip, Marcelo, Marialuisa, Ficorilli, James, Li, Shuyu, Gao, Hong, Ryan, Timothy P., Michael, M. Dodson, Michael, Laura F.

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Oral Muvalaplin for Lowering of Lipoprotein(a): A Randomized Clinical Trial von Nicholls, Stephen J, Ni, Wei, Rhodes, Grace M, Nissen, Steven E, Navar, Ann Marie, Michael, Laura F, Haupt, Axel, Krege, John H

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Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms von van den Borne, Pleunie, van der Laan, Sander W, Bovens, Sandra M, Koole, Dave, Kowala, Mark C, Michael, Laura F, Schoneveld, Arjan H, van de Weg, Sander M, Velema, Evelyn, de Vries, Jean-Paul, de Borst, Gert J, Moll, Frans L, de Kleijn, Dominique P V, Quax, Paul H A, Hoefer, Imo E, Pasterkamp, Gerard

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Discovery of potent small-molecule inhibitors of lipoprotein(a) formation von Diaz, Nuria, Perez, Carlos, Escribano, Ana Maria, Sanz, Gema, Priego, Julian, Lafuente, Celia, Barberis, Mario, Calle, Luis, Espinosa, Juan Felix, Priest, Birgit T., Zhang, Hong Y., Nosie, Amanda K., Haas, Joseph V., Cannady, Ellen, Borel, Anthony, Schultze, Albert E., Sauder, J. Michael, Hendle, Jörg, Weichert, Ken, Nicholls, Stephen J., Michael, Laura F.

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The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage von Jin, Najia, Matter, William F, Michael, Laura F, Qian, Yuewei, Gheyi, Tarun, Cano, Leticia, Perez, Carlos, Lafuente, Celia, Broughton, Howard B, Espada, Alfonso

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Genome-wide Screen for Modulation of Hepatic Apolipoprotein A-I (ApoA-I) Secretion von Miles, Rebecca R., Perry, William, Haas, Joseph V., Mosior, Marian K., N'Cho, Mathias, Wang, JianW.J., Yu, Peng, Calley, John, Yue, Yong, Carter, Quincy, Han, Bomie, Foxworthy, Patricia, Kowala, Mark C., Ryan, Timothy P., Solenberg, Patricia J., Michael, Laura F.

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Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin von Swearingen, Craig A, Sloan, John H, Rhodes, Grace M, Siegel, Robert W, Bivi, Nico, Qian, Yuewei, Konrad, Robert J, Boffa, Michael, Koschinsky, Marlys, Krege, John, Ruotolo, Giacomo, Nicholls, Stephen J, Michael, Laura F, Wen, Yi

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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres von Spiegelman, Bruce M, Lin, Jiandie, Wu, Hai, Tarr, Paul T, Zhang, Chen-Yu, Wu, Zhidan, Boss, Olivier, Michael, Laura F, Puigserver, Pere, Isotani, Eiji, Olson, Eric N, Lowell, Bradford B, Bassel-Duby, Rhonda

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Disentangling the genetic overlap between cholesterol and suicide risk von Knowles, Emma E M, Curran, Joanne E, Meikle, Peter J, Huynh, Kevin, Mathias, Samuel R, Göring, Harald H H, VandeBerg, John L, Mahaney, Michael C, Jalbrzikowski, Maria, Mosior, Marian K, Michael, Laura F, Olvera, Rene L, Duggirala, Ravi, Almasy, Laura, Glahn, David C, Blangero, John

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A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity von Schmidt, Robert J., Ficorilli, James V., Zhang, Youyan, Bramlett, Kelli S., Beyer, Thomas P., Borchert, Kristen, Dowless, Michele S., Houck, Keith A., Burris, Thomas P., Eacho, Patrick I., Liang, Guosheng, Guo, Li-wei, Wilson, William K., Michael, Laura F., Cao, Guoqing

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T0901317 is a dual LXR/FXR agonist von Houck, Keith A., Borchert, Kristen M., Hepler, Christopher D., Thomas, Jeffrey S., Bramlett, Kelli S., Michael, Laura F., Burris, Thomas P.

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Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3 von Blackburn, Nicholas B., Meikle, Peter J., Peralta, Juan M., Kumar, Satish, Leandro, Ana C., Bellinger, Melissa A., Giles, Corey, Huynh, Kevin, Mahaney, Michael C., Göring, Harald H.H., VandeBerg, John L., Williams-Blangero, Sarah, Glahn, David C., Duggirala, Ravindranath, Blangero, John, Michael, Laura F., Curran, Joanne E.

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