Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine in patients with refractory solid tumors von Italiano, A., Infante, J.R., Shapiro, G.I., Moore, K.N., LoRusso, P.M., Hamilton, E., Cousin, S., Toulmonde, M., Postel-Vinay, S., Tolaney, S., Blackwood, E.M., Mahrus, S., Peale, F.V., Lu, X., Moein, A., Epler, J., DuPree, K., Tagen, M., Murray, E.R., Schutzman, J.L., Lauchle, J.O., Hollebecque, A., Soria, J.-C.

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495 The PI3K/mTOR Inhibitor GDC-0980 Demonstrates Target Engagement and Pathway Modulation in Tumor Tissue at Tolerated Doses von Yan, Y, Spoerke, J, Wu, J, Desai, R, Koeppen, H, Hampton, G, Fredrickson, J, Derynck, M, Lauchle, J, Lackner, M

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Abstract P5-11-01: Phamacodynamic and circulating tumor DNA evaluation in a phase I study of GDC-0927, a selective estrogen receptor antagonist/ degrader (SERD) von Spoerke, JM, Daemen, A, Chang, C-W, Giltnane, J, Metcalfe, C, Dickler, MN, Bardia, A, Perez Fidalgo, JA, Mayer, IA, Boni, V, Winer, EP, Hamilton, EP, Bellet, M, Urruticoechea, A, Gonzalez Martin, A, Cortes, J, Martin, M, Gates, M, Cheeti, S, Fredrickson, J, Wang, X, Friedman, LS, Liu, L, Li, R, Chan, IT, Mueller, L, Milan, S, Lauchle, J, Humke, EW, Lackner, MR

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Phase I study of the checkpoint kinase 1 inhibitor GDC-0575 in combination with gemcitabine (gem) in patients (pts) with refractory solid tumors von Italiano, A., Infante, J.R., Shapiro, G., Moore, K.N., Lorusso, P., Postel-Vinay, S., Cousin, S., Toulmonde, M., Lucchesi, C., Blackwood, E., Mahrus, S., Lu, X., Tagen, M., Schutzman, J., Lauchle, J., Soria, J-C.

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Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive... von Dickler, MN, Villanueva, R, Perez Fidalgo, JA, Mayer, IA, Boni, V, Winer, EP, Hamilton, EP, Bellet, M, Urruticoechea, A, Gonzalez-Martin, A, Cortes, J, Martin, M, Giltnane, J, Gates, M, Cheeti, S, Fredrickson, J, Wang, X, Friedman, LS, Spoerke, JM, Metcalfe, C, Liu, L, Li, R, Morley, R, McCurry, U, Chan, IT, Mueller, L, Milan, S, Lauchle, J, Humke, EW, Bardia, A

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389 A phase I study evaluating the pharmacokinetics (PK) and pharmacodynamic (PD) activity of the dual PI3K/mTor inhibitor GDC-0980 administered QW von Wagner, A.J, Jayson, G.C, Gomez-Roca, C, Zee, Y.K, Morgan, J.A, Yan, Y, Ware, J, Mazina, K.E, Lauchle, J, Soria, J.C

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Inherited predispositions and hyperactive Ras in myeloid leukemogenesis von Lauchle, Jennifer O., Braun, Benjamin S., Loh, Mignon L., Shannon, Kevin

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A first-in-human phase I study to evaluate GDC-0980, an oral PI3K/mTOR inhibitor, administered QD in patients with advanced solid tumors von Wagner, A. J., Bendell, J. C., Dolly, S., Morgan, J. A., Ware, J. A., Fredrickson, J., Mazina, K. E., Lauchle, J. O., Burris, H. A., De Bono, J. S.

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Somatic inactivation of Nfl in hematopoietic cells results in a progressive myeloproliferative disorder von LE, Doan T, NAMIE KONG, SHANNON, Kevin M, YUAN ZHU, LAUCHLE, Jennifer O, AIYIGARI, Abigail, BRAUN, Benjamin S, ENDI WANG, KOGAN, Scott C, LE BEAU, Michelle M, PARADA, Luis

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Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22 von Curtiss, Nicole P., Bonifas, Jeannette M., Lauchle, Jennifer O., Balkman, Jason D., Kratz, Christian P., Emerling, Brooke M., Green, Eric D., Le Beau, Michelle M., Shannon, Kevin M.

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Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors von Dolly, Saoirse O, Wagner, Andrew J, Bendell, Johanna C, Kindler, Hedy L, Krug, Lee M, Seiwert, Tanguy Y, Zauderer, Marjorie G, Lolkema, Martijn P, Apt, Doris, Yeh, Ru-Fang, Fredrickson, Jill O, Spoerke, Jill M, Koeppen, Hartmut, Ware, Joseph A, Lauchle, Jennifer O, Burris, 3rd, Howard A, de Bono, Johann S

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Aerodynamic lift and drag fluctuations of a sphere von HOWE, M. S., LAUCHLE, G. C., WANG, J.

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Development of a velocity gradient underwater acoustic intensity sensor von Bastyr, Kevin J., Lauchle, Gerald C., McConnell, James A.

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Abstract A03: Comprehensive predictive biomarker evaluation in two phase II clinical trials of the PI3K/mTOR inhibitor GDC-0980 in metastatic renal cell carcinoma and advanced endo... von Spoerke, Jill M., Makker, Vicky, Aghajanian, Carol, Thomas, Powles, Motzer, Robert J., Lauchle, Jennifer O., Parmar, Hema, Gilbert, Houston, Lin, Wei, O'Keeffe, Bridget, Byrtek, Michelle, Koeppen, Hartmut, Wang, Yulei, Lu, Shan, Huw, Ling-Yuh, Hampton, Garret M., Lackner, Mark R.

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Flow-induced force fluctuations on a sphere at high Strouhal number von Wang, J., Lauchle, G.C., Howe, M.S.

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Abstract B153: A phase I study evaluating the pharmacokinetics (PK) and pharmacodynamic (PD) activity of the dual PI3K/mTOR inhibitor GDC-0980 administered once weekly (QW) von Hollebecque, Antoine, Clamp, Andrew, Horsley, Laura, Morgan, Jeffrey A., Bahleda, Rastilav, George, Suzanne, Shaw, Danielle, Lauchle, Jennifer O., Ware, Joseph, Desai, Rupal, Wu, Jenny, Fu, Ling, Jayson, Gordon C., Soria, Jean-Charles, Wagner, Andrew J.

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Flow-induced noise on a pressure-acceleration underwater acoustic intensity probe von McConnell, James A., Lauchle, Gerald C.

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Flow-induced noise on a bluff body von McEachern, James F., Lauchle, Gerald C.

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Acoustic intensity in the interaction region of a parametric source von Lauchle, G. C., Gabrielson, T. B., Van Tol, D. J., Kottke, N. F., McConnell, J. A.

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Preliminary results of water tunnel acoustic measurements using a time reversal mirror von Barber, Christopher, Lauchle, Gerald C., Kottke, Nelson J.

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