R-spondin protein family von de Lau, Wim BM, Snel, Berend, Clevers, Hans C

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A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses von Beumer, Joep, Geurts, Maarten H., Lamers, Mart M., Puschhof, Jens, Zhang, Jingshu, van der Vaart, Jelte, Mykytyn, Anna Z., Breugem, Tim I., Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B., de Lau, Wim, Pleguezuelos-Manzano, Cayetano, Busslinger, Georg, Haagmans, Bart L., Clevers, Hans

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The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength von de Lau, Wim, Peng, Weng Chuan, Gros, Piet, Clevers, Hans

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Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5 von Peng, Weng Chuan, de Lau, Wim, Forneris, Federico, Granneman, Joke C.M., Huch, Meritxell, Clevers, Hans, Gros, Piet

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Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling von Janda, Claudia Y., Dang, Luke T., You, Changjiang, Chang, Junlei, de Lau, Wim, Zhong, Zhendong A., Yan, Kelley S., Marecic, Owen, Siepe, Dirk, Li, Xingnan, Moody, James D., Williams, Bart O., Clevers, Hans, Piehler, Jacob, Baker, David, Kuo, Calvin J., Garcia, K. Christopher

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Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells von Kemper, Kristel, Prasetyanti, Pramudita R., De Lau, Wim, Rodermond, Hans, Clevers, Hans, Medema, Jan Paul

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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo von Miao, Yi, Ha, Andrew, de Lau, Wim, Yuki, Kanako, Santos, António J.M., You, Changjiang, Geurts, Maarten H., Puschhof, Jens, Pleguezuelos-Manzano, Cayetano, Peng, Weng Chuan, Senlice, Ramazan, Piani, Carol, Buikema, Jan W., Gbenedio, Oghenekevwe M., Vallon, Mario, Yuan, Jenny, de Haan, Sanne, Hemrika, Wieger, Rösch, Kathrin, Dang, Luke T., Baker, David, Ott, Melanie, Depeille, Philippe, Wu, Sean M., Drost, Jarno, Nusse, Roeland, Roose, Jeroen P., Piehler, Jacob, Boj, Sylvia F., Janda, Claudia Y., Clevers, Hans, Kuo, Calvin J., Garcia, K. Christopher

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Peyer's Patch M Cells Derived from Lgr5+ Stem Cells Require SpiB and Are Induced by RankL in Cultured “Miniguts” von de Lau, Wim, Kujala, Pekka, Schneeberger, Kerstin, Middendorp, Sabine, Li, Vivian S. W., Barker, Nick, Martens, Anton, Hofhuis, Frans, DeKoter, Rodney P., Peters, Peter J., Nieuwenhuis, Edward, Clevers, Hans

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Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling von Peng, Weng Chuan, de Lau, Wim, Madoori, Pramod K, Forneris, Federico, Granneman, Joke C M, Clevers, Hans, Gros, Piet

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Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade von Ng, Ser Sue, Mahmoudi, Tokameh, Danenberg, Esther, Bejaoui, Inés, de Lau, Wim, Korswagen, Hendrik C., Schutte, Mieke, Clevers, Hans

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Method for estimating the single molecular affinity von Schasfoort, Richard B.M., de Lau, Wim, van der Kooi, Alex, Clevers, Hans, Engbers, Gerard H.M.

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Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins von Ren, Zemin, van Andel, Harmen, de Lau, Wim, Hartholt, Robin B., Maurice, Madelon M., Clevers, Hans, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling von de Lau, Wim, Barker, Nick, Low, Teck Y., Koo, Bon-Kyoung, Li, Vivian S. W., Teunissen, Hans, Kujala, Pekka, Haegebarth, Andrea, Peters, Peter J., van de Wetering, Marc, Stange, D. E., van Es, J., Guardavaccaro, Daniele, Schasfoort, Richard B. M., Mohri, Yasuaki, Nishimori, Katsuhiko, Mohammed, Shabaz, Heck, Albert J. R., Clevers, Hans

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Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets von Wijnakker, Joost J A P M, van Son, Gijs J F, Krueger, Daniel, van de Wetering, Willine J, Lopez-Iglesias, Carmen, Schreurs, Robin, van Rijt, Fenna, Lim, Sangho, Lin, Lin, Peters, Peter J, Isberg, Ralph R, Janda, Claudia Y, de Lau, Wim, Clevers, Hans

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Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins von van Andel, Harmen, Ren, Zemin, Koopmans, Iris, Joosten, Sander P. J., Kocemba, Kinga A., de Lau, Wim, Kersten, Marie José, de Bruin, Alexander M., Guikema, Jeroen E. J., Clevers, Hans, Spaargaren, Marcel, Pals, Steven T.

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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells von van de Wetering, Marc, Sancho, Elena, Verweij, Cornelis, de Lau, Wim, Oving, Irma, Hurlstone, Adam, van der Horn, Karin, Batlle, Eduard, Coudreuse, Damien, Haramis, Anna-Pavlina, Tjon-Pon-Fong, Menno, Moerer, Petra, van den Born, Maaike, Soete, Gwen, Pals, Steven, Eilers, Martin, Medema, Rene, Clevers, Hans

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A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses von Beumer, Joep, Geurts, Maarten H, Lamers, Mart M, Puschhof, Jens, Zhang, Jingshu, van der Vaart, Jelte, Mykytyn, Anna Z, Breugem, Tim I, Riesebosch, Samra, Schipper, Debby, van den Doel, Petra B, de Lau, Wim, Pleguezuelos-Manzano, Cayetano, Busslinger, Georg, Haagmans, Bart L, Clevers, Hans

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The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength von de Lau, Wim, Peng, Weng Chuan, Gros, Piet, Clevers, Hans

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LEF1 turns over a new leaf von Lau, Wim de, Clevers, Hans

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Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids von Herpers, Bram, Roovers, Rob, Eppink, Berina, Wetering, Marc Van de, Yan, Kuan, Salinaro, Lucia, Lau, Wim De, Clevers, Hans, Vries, Robert, Throsby, Mark, Price, Leo

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