TRK Inhibition: A New Tumor-Agnostic Treatment Strategy von Kummar, Shivaani, Lassen, Ulrik N.

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A systematic review of targeted agents for non-small cell lung cancer von Vestergaard, Hannah H., Christensen, Marcus R., Lassen, Ulrik N.

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Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib von Yang, James C H, Brose, Marcia S, Castro, Gilberto, Kim, Edward S, Lassen, Ulrik N, Leyvraz, Serge, Pappo, Alberto, López-Ríos, Fernando, Reeves, John A, Fellous, Marc, Penault-Llorca, Frédérique, Rudzinski, Erin R, Tabatabai, Ghazaleh, Vassal, Gilles, Drilon, Alexander, Trent, Jonathan

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Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children von Drilon, Alexander, Laetsch, Theodore W, Kummar, Shivaani, DuBois, Steven G, Lassen, Ulrik N, Demetri, George D, Nathenson, Michael, Doebele, Robert C, Farago, Anna F, Pappo, Alberto S, Turpin, Brian, Dowlati, Afshin, Brose, Marcia S, Mascarenhas, Leo, Federman, Noah, Berlin, Jordan, El-Deiry, Wafik S, Baik, Christina, Deeken, John, Boni, Valentina, Nagasubramanian, Ramamoorthy, Taylor, Matthew, Rudzinski, Erin R, Meric-Bernstam, Funda, Sohal, Davendra P.S, Ma, Patrick C, Raez, Luis E, Hechtman, Jaclyn F, Benayed, Ryma, Ladanyi, Marc, Tuch, Brian B, Ebata, Kevin, Cruickshank, Scott, Ku, Nora C, Cox, Michael C, Hawkins, Douglas S, Hong, David S, Hyman, David M

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Precision oncology: a clinical and patient perspective von Lassen, Ulrik N, Makaroff, Lydia E, Stenzinger, Albrecht, Italiano, Antoine, Vassal, Gilles, Garcia-Foncillas, Jesus, Avouac, Bernard

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Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas von Kummar, Shivaani, Shen, Lin, Hong, David S, McDermott, Ray, Keedy, Vicki L, Casanova, Michela, Demetri, George D, Dowlati, Afshin, Melcón, Soledad Gallego, Lassen, Ulrik N, Leyvraz, Serge, Liu, Tianshu, Moreno, Victor, Patel, Jyoti, Patil, Tejas, Mallick, Atrayee Basu, Sousa, Nuno, Tahara, Makoto, Ziegler, David S, Norenberg, Ricarda, Arvis, Pierre, Brega, Nicoletta, Drilon, Alexander, Tan, Daniel S W

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First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors von Meulendijks, Didier, Jacob, Wolfgang, Martinez-Garcia, Maria, Taus, Alvaro, Lolkema, Martijn P, Voest, Emile E, Langenberg, Marlies H G, Fleitas Kanonnikoff, Tania, Cervantes, Andres, De Jonge, Maja J, Sleijfer, Stefan, Soerensen, Morten Mau, Thomas, Marlene, Ceppi, Maurizio, Meneses-Lorente, Georgina, James, Ian, Adessi, Celine, Michielin, Francesca, Abiraj, Keelara, Bossenmaier, Birgit, Schellens, Jan H M, Weisser, Martin, Lassen, Ulrik N

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Phase Ib Study of Lumretuzumab Plus Cetuximab or Erlotinib in Solid Tumor Patients and Evaluation of HER3 and Heregulin as Potential Biomarkers of Clinical Activity von Meulendijks, Didier, Jacob, Wolfgang, Voest, Emile E, Mau-Sorensen, Morten, Martinez-Garcia, Maria, Taus, Alvaro, Fleitas, Tania, Cervantes, Andres, Lolkema, Martijn P, Langenberg, Marlies H G, De Jonge, Maja J, Sleijfer, Stefan, Han, Ji-Youn, Calles, Antonio, Felip, Enriqueta, Kim, Sang-We, Schellens, Jan H M, Wilson, Sabine, Thomas, Marlene, Ceppi, Maurizio, Meneses-Lorente, Georgina, James, Ian, Vega-Harring, Suzana, Dua, Rajiv, Nguyen, Maitram, Steiner, Lori, Adessi, Celine, Michielin, Francesca, Bossenmaier, Birgit, Weisser, Martin, Lassen, Ulrik N

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Quality of Life in Adult and Pediatric Patients with Tropomyosin Receptor Kinase Fusion Cancer Receiving Larotrectinib von Kummar, Shivaani, Berlin, Jordan, Mascarenhas, Leo, van Tilburg, Cornelis M., Geoerger, Birgit, Lassen, Ulrik N., Schilder, Russell J., Turpin, Brian, Nanda, Shivani, Keating, Karen, Childs, Barrett H., Chirila, Costel, Laetsch, Theodore W., Hyman, David M., Drilon, Alexander, Hong, David S.

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A phase I monotherapy study of RG7212, a first-in-class monoclonal antibody targeting TWEAK signaling in patients with advanced cancers von Lassen, Ulrik N, Meulendijks, Didier, Siu, Lilian L, Karanikas, Vaios, Mau-Sorensen, Morten, Schellens, Jan H M, Jonker, Derek J, Hansen, Aaron R, Simcox, Mary E, Schostack, Kathleen J, Bottino, Dean, Zhong, Hua, Roessler, Markus, Vega-Harring, Suzana M, Jarutat, Tiantom, Geho, David, Wang, Ka, DeMario, Mark, Goss, Glenwood D

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Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors von Meulendijks, Didier, Lassen, Ulrik N, Siu, Lillian L, Huitema, Alwin D R, Karanikas, Vaios, Mau-Sorensen, Morten, Jonker, Derek J, Hansen, Aaron R, Simcox, Mary E, Schostack, Kathleen J, Bottino, Dean, Zhong, Hua, Roessler, Markus, Vega-Harring, Suzana M, Jarutat, Tiantom, Geho, David, Wang, Karen, DeMario, Mark, Goss, Glenwood D, Schellens, Jan H M

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CTNI-07. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TRK FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS von Perreault, Sébastien, Spano, Jean-Philippine, Nilsson, Anna, Deyell, Rebecca J, Doz, François, Geoerger, Birgit, Gumus, Mahmut, Lassen, Ulrik N, Nysom, Karsten, Valero-Arrese, Lorena, Idbaih, Ahmed, Bernard-Gauthier, Vadim, Neu, Natascha, Brega, Nicoletta, Drilon, Alexander, Laetsch, Theodore W, van Tilburg, Cornelis M

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CTNI-62. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS von Perreault, Sébastien, Drilon, Alexander, Lassen, Ulrik N, Geoerger, Birgit, Nysom, Karsten, Øra, Ingrid, Gavrilovic, Igor T, Norenberg, Ricarda, Bernard-Gauthier, Vadim, De La Cuesta, Esther, Laetsch, Theodore W, Doz, François, Van Tilburg, Cornelis M

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Abstract CT199: Larotrectinib in TRK fusion cancer patients: Outcomes by prior therapy and performance status von Drilon, Alexander, van Tilburg, Cornelis M., Farago, Anna F., Kummar, Shivaani, Berlin, Jordan, Albert, Catherine M., McDermott, Ray, Lassen, Ulrik N., Reeves, John A., Brega, Nicoletta, Childs, Barrett H., Laetsch, Theodore W., Hong, David S.

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CTNI-04. ACTIVITY OF LAROTRECTINIB IN TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION CANCER PATIENTS WITH CENTRAL NERVOUS SYSTEM (CNS) METASTASES von Patel, Jyoti D, Farago, Anna F, Hong, David S, Lassen, Ulrik N, Leyvraz, Serge, Park, Keunchil, Sohal, Davendra P S, Solomon, Benjamin, Reeves, John A, Dima, Laura, Brega, Nicoletta, Drilon, Alexander

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A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors von de Weger, Vincent A, Goel, Sanjay, von Moos, Roger, Schellens, Jan H M, Mach, Nicholas, Tan, Eugene, Anand, Suraj, Scott, Jeffrey W, Lassen, Ulrik N

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Abstract CT228: Concordance between tissue and circulating tumor DNA (ctDNA) testing for neurotrophic tyrosine receptor kinase ( NTRK ) gene fusions in larotrectinib (laro) clinica... von Rudzinski, Erin R., Ladanyi, Marc, Ritterhouse, Lauren L., Sahm, Felix, Norenberg, Ricarda, Zheng, Hong, Chen, Chi, Bernard-Gauthier, Vadim, Brega, Nicoletta, van Tilburg, Cornelis M., Lin, Jessica J., Brose, Marcia S., Lassen, Ulrik N., McDermott, Ray, Laetsch, Theodore W., Hong, David S., Drilon, Alexander, Roy-Chowdhuri, Sinchita

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Abstract CT545: Variability in NTRK gene fusions does not appear to impact response to larotrectinib von Ladanyi, Marc, Roy-Chowdhuri, Sinchita, Ritterhouse, Lauren, Sahm, Felix, Norenberg, Ricarda, Shen, Kui, Chen, Chi, Fellous, Marc, Brega, Nicoletta, van Tilburg, Cornelis M., Lin, Jessica J., Brose, Marcia S., Lassen, Ulrik N., McDermott, Ray, Laetsch, Theodore W., Hong, David S., Drilon, Alexander, Rudzinski, Erin R.

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Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors von Meulendijks, Didier, Lassen, Ulrik N, Siu, Lillian L, Huitema, Alwin D R, Karanikas, Vaios, Mau-Sorensen, Morten, Jonker, Derek J, Hansen, Aaron R, Simcox, Mary E, Schostack, Kathleen J, Bottino, Dean, Zhong, Hua, Roessler, Markus, Vega-Harring, Suzana M, Jarutat, Tiantom, Geho, David, Wang, Karen, DeMario, Mark, Goss, Glenwood D, Schellens, Jan H M

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Outcome of combination chemotherapy in extensive stage small-cell lung cancer: Any treatment related progress? von Lassen, Ulrik N, Hirsch, Fred R, Østerlind, Kell, Bergman, Bengt, Dombernowsky, Per

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