Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome von Knights, Dan, Lassen, Kara G, Xavier, Ramnik J

Volltext

Mechanisms and function of autophagy in intestinal disease von Lassen, Kara G., Xavier, Ramnik J.

Volltext

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense von Lassen, Kara G., Kuballa, Petric, Conway, Kara L., Patel, Khushbu K., Becker, Christine E., Peloquin, Joanna M., Villablanca, Eduardo J., Norman, Jason M., Liu, Ta-Chiang, Heath, Robert J., Becker, Morgan L., Fagbami, Lola, Horn, Heiko, Mercer, Johnathan, Yilmaz, Omer H., Jaffe, Jacob D., Shamji, Alykhan F., Bhan, Atul K., Carr, Steven A., Daly, Mark J., Virgin, Herbert W., Schreiber, Stuart L., Stappenbeck, Thaddeus S., Xavier, Ramnik J.

Volltext

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk von Lassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R., Xavier, Ramnik J.

Volltext

Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice von Ferder, Ianina C, Fung, Leslie, Ohguchi, Yasuyo, Zhang, Xiaoyu, Lassen, Kara G, Capen, Diane, Brown, Dennis, Xavier, Ramnik J, Wang, Ning

Volltext

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells von Selleck, Elizabeth M, Orchard, Robert C, Lassen, Kara G, Beatty, Wandy L, Xavier, Ramnik J, Levine, Beth, Virgin, Herbert W, Sibley, L David

Volltext

The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response von Lavoie, Sydney, Conway, Kara L, Lassen, Kara G, Jijon, Humberto B, Pan, Hui, Chun, Eunyoung, Michaud, Monia, Lang, Jessica K, Gallini Comeau, Carey Ann, Dreyfuss, Jonathan M, Glickman, Jonathan N, Vlamakis, Hera, Ananthakrishnan, Ashwin, Kostic, Aleksander, Garrett, Wendy S, Xavier, Ramnik J

Volltext

RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy von Heath, Robert J., Goel, Gautam, Baxt, Leigh A., Rush, Jason S., Mohanan, Vishnu, Paulus, Geraldine L.C., Jani, Vijay, Lassen, Kara G., Xavier, Ramnik J.

Volltext

A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs von Lassen, Kara G, Hebbeler, Andrew M, Bhattacharyya, Darshana, Lobritz, Michael A, Greene, Warner C

Volltext

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 von Khor, Bernard, Conway, Kara L, Omar, Abdifatah S, Biton, Moshe, Haber, Adam L, Rogel, Noga, Baxt, Leigh A, Begun, Jakob, Kuballa, Petric, Gagnon, John D, Lassen, Kara G, Regev, Aviv, Xavier, Ramnik J

Volltext

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics von Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.

Volltext

Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIV von Chan, Jonathan K, Bhattacharyya, Darshana, Lassen, Kara G, Ruelas, Debbie, Greene, Warner C

Volltext

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1) von Sakane, Naoki, Kwon, Hye-Sook, Pagans, Sara, Kaehlcke, Katrin, Mizusawa, Yasuhiro, Kamada, Masafumi, Lassen, Kara G, Chan, Jonathan, Greene, Warner C, Schnoelzer, Martina, Ott, Melanie

Volltext

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo von Murano, Tatsuro, Najibi, Mehran, Paulus, Geraldine L. C., Adiliaghdam, Fatemeh, Valencia-Guerrero, Aida, Selig, Martin, Wang, Xiaofei, Jeffrey, Kate, Xavier, Ramnik J., Lassen, Kara G., Irazoqui, Javier E.

Volltext

Integrated Genomics of Crohn’s Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy von Begun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A.B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca, Xavier, Ramnik J.

Volltext

Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells von Lassen, Kara G, Ramyar, Kasra X, Bailey, Justin R, Zhou, Yan, Siliciano, Robert F

Volltext

IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies von Friedrich, Matthias, Pohin, Mathilde, Jackson, Matthew A., Korsunsky, Ilya, Bullers, Samuel J., Rue-Albrecht, Kevin, Christoforidou, Zoe, Sathananthan, Dharshan, Thomas, Tom, Ravindran, Rahul, Tandon, Ruchi, Peres, Raphael Sanches, Sharpe, Hannah, Wei, Kevin, Watts, Gerald F. M., Mann, Elizabeth H., Geremia, Alessandra, Attar, Moustafa, McCuaig, Sarah, Thomas, Lloyd, Collantes, Elena, Uhlig, Holm H., Sansom, Stephen N., Easton, Alistair, Raychaudhuri, Soumya, Travis, Simon P., Powrie, Fiona M.

Volltext

Neutralizing Antibodies Do Not Mediate Suppression of Human Immunodeficiency Virus Type 1 in Elite Suppressors or Selection of Plasma Virus Variants in Patients on Highly Active An... von BAILEY, Justin R, LASSEN, Kara G, YANG, Hung-Chih, QUINN, Thomas C, RAY, Stuart C, BLANKSON, Joel N, SILICIANO, Robert F

Volltext

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules von Shaw, Stanley Y, Tran, Khoa, Castoreno, Adam B, Peloquin, Joanna M, Lassen, Kara G, Khor, Bernard, Aldrich, Leslie N, Tan, Pauline H, Graham, Daniel B, Kuballa, Petric, Goel, Gautam, Daly, Mark J, Shamji, Alykhan F, Schreiber, Stuart L, Xavier, Ramnik J

Volltext

Analysis of Human Immunodeficiency Virus Type 1 Transcriptional Elongation in Resting CD4+ T Cells In Vivo von LASSEN, Kara G, BAILEY, Justin R, SILICIANO, Robert F

Volltext