Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein von Järås, Marcus, Johnels, Petra, Hansen, Nils, Ågerstam, Helena, Tsapogas, Panagiotis, Rissler, Marianne, Lassen, Carin, Olofsson, Tor, Bjerrum, Ole Weis, Richter, Johan, Fioretos, Thoas

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Molecular Signatures in Childhood Acute Leukemia and Their Correlations to Expression Patterns in Normal Hematopoietic Subpopulations von Anna Andersson, Tor Olofsson, David Lindgren, Nilsson, Björn, Cecilia Ritz, Patrik Edén, Carin Lassen, Johan Råde, Magnus Fontes, Helena Mörse, Jesper Heldrup, Mikael Behrendtz, Mitelman, Felix, Höglund, Mattias, Johansson, Bertil, Thoas Fioretos

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Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice von Ågerstam, Helena, Järås, Marcus, Andersson, Anna, Johnels, Petra, Hansen, Nils, Lassen, Carin, Rissler, Marianne, Gisselsson, David, Olofsson, Tor, Richter, Johan, Fan, Xiaolong, Ehinger, Mats, Fioretos, Thoas

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Clinical impact of internal tandem duplications and activating point mutations in FLT3 in acute myeloid leukemia in elderly patients von Andersson, Anna, Johansson, Bertil, Lassen, Carin, Mitelman, Felix, Billström, Rolf, Fioretos, Thoas

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Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients von Mustjoki, S, Richter, J, Barbany, G, Ehrencrona, H, Fioretos, T, Gedde-Dahl, T, Gjertsen, B T, Hovland, R, Hernesniemi, S, Josefsen, D, Koskenvesa, P, Dybedal, I, Markevärn, B, Olofsson, T, Olsson-Strömberg, U, Rapakko, K, Thunberg, S, Stenke, L, Simonsson, B, Porkka, K, Hjorth-Hansen, H

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Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/ CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia von PANAGOPOULOS, I, LASSEN, C, ISAKSSON, M, MITELMAN, F, MANDAHL, N, AMAN, P

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IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome von Landberg, N, Hansen, N, Askmyr, M, Ågerstam, H, Lassen, C, Rissler, M, Hjorth-Hansen, H, Mustjoki, S, Järås, M, Richter, J, Fioretos, T

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Microarray-based classification of a consecutive series of 121 childhood acute leukemias: prediction of leukemic and genetic subtype as well as of minimal residual disease status von ANDERSSON, A, RITZ, C, BEHRENDTZ, M, HÖGLUND, M, JOHANSSON, B, FIORETOS, T, LINDGREN, D, EDEN, P, LASSEN, C, HELDRUP, J, OLOFSSON, T, RADE, J, FONTES, M, PORWIT-MACDONALD, A

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Whole-exome sequencing of pediatric acute lymphoblastic leukemia von Lilljebjörn, H, Rissler, M, Lassen, C, Heldrup, J, Behrendtz, M, Mitelman, F, Johansson, B, Fioretos, T

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Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells von Askmyr, Maria, Agerstam, Helena, Lilljebjörn, Henrik, Hansen, Nils, Karlsson, Christine, Landberg, Niklas, Hogberg, Carl, Lassen, Carin, Rissler, Marianne, Richter, Johan, Ehinger, Mats, Jaras, Marcus, Fioretos, Thoas

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The t(X;7)(q22;q34) in paediatric T‐cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with th... von Karrman, Kristina, Kjeldsen, Eigil, Lassen, Carin, Isaksson, Margareth, Davidsson, Josef, Andersson, Anna, Hasle, Henrik, Fioretos, Thoas, Johansson, Bertil

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Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutat... von Larsson, Nina, Lilljebjörn, Henrik, Lassen, Carin, Johansson, Bertil, Fioretos, Thoas

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Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome von Ågerstam, Helena, Lilljebjörn, Henrik, Lassen, Carin, Swedin, Agneta, Richter, Johan, Vandenberghe, Peter, Johansson, Bertil, Fioretos, Thoas

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Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryp... von LILLJEBJÖRN, H, HEIDENBLAD, M, NILSSON, B, LASSEN, C, HORVAT, A, HELDRUP, J, BEHRENDTZ, M, JOHANSSON, B, ANDERSSON, A, FIORETOS, T

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Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations von ANDERSSON, A, EDEN, P, HÖGLUND, M, FIORETOS, T, LINDGREN, D, NILSSON, J, LASSEN, C, HELDRUP, J, FONTES, M, BORG, A, MITELMAN, F, JOHANSSON, B

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Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cells von SVENSSON, E, VIDOVIC, K, LASSEN, C, RICHTER, J, OLOFSSON, T, FIORETOS, T, GULLBERG, U

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Gene expression analysis of BCR/ABL1-dependent transcriptional response reveals enrichment for genes involved in negative feedback regulation von Håkansson, Petra, Nilsson, Björn, Andersson, Anna, Lassen, Carin, Gullberg, Urban, Fioretos, Thoas

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Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells von Askmyr, M, Ågerstam, H, Lilljebjörn, H, Hansen, N, Karlsson, C, von Palffy, S, Landberg, N, Högberg, C, Lassen, C, Rissler, M, Richter, J, Ehinger, M, Järås, M, Fioretos, T

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FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns von Andersson, Anna, Paulsson, Kajsa, Lilljebjörn, Henrik, Lassen, Carin, Strömbeck, Bodil, Heldrup, Jesper, Behrendtz, Mikael, Johansson, Bertil, Fioretos, Thoas

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A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a res... von BARBOUTI, Aikaterini, HÖGLUND, Mattias, JOHANSSON, Bertil, LASSEN, Carin, NILSSON, Per-Gunnar, HAGEMEIJER, Anne, MITELMAN, Felix, FIORETOS, Thoas

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