Structural Basis of Substrate Methylation and Inhibition of SMYD2 von Ferguson, Andrew D., Larsen, Nicholas A., Howard, Tina, Pollard, Hannah, Green, Isabelle, Grande, Christie, Cheung, Tony, Garcia-Arenas, Renee, Cowen, Scott, Wu, Jiaquan, Godin, Robert, Chen, Huawei, Keen, Nicholas

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Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors von Cretu, Constantin, Gee, Patricia, Liu, Xiang, Agrawal, Anant, Nguyen, Tuong-Vi, Ghosh, Arun K., Cook, Andrew, Jurica, Melissa, Larsen, Nicholas A., Pena, Vladimir

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The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action von Finci, Lorenzo I, Zhang, Xiaofeng, Huang, Xiuliang, Zhou, Qiang, Tsai, Jennifer, Teng, Teng, Agrawal, Anant, Chan, Betty, Irwin, Sean, Karr, Craig, Cook, Andrew, Zhu, Ping, Reynolds, Dominic, Smith, Peter G, Fekkes, Peter, Buonamici, Silvia, Larsen, Nicholas A

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Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)‑7-Oxozeaenol von Wu, Jiaquan, Powell, Francoise, Larsen, Nicholas A, Lai, Zhongwu, Byth, Kate F, Read, Jon, Gu, Rong-Fang, Roth, Mark, Toader, Dorin, Saeh, Jamal Carlos, Chen, Huawei

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BluB cannibalizes flavin to form the lower ligand of vitamin B12 von Taga, Michiko E., Larsen, Nicholas A., Howard-Jones, Annaleise R., Walsh, Christopher T., Walker, Graham C.

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Crystal Structure of a TOG Domain: Conserved Features of XMAP215/Dis1-Family TOG Domains and Implications for Tubulin Binding von Al-Bassam, Jawdat, Larsen, Nicholas A., Hyman, Anthony A., Harrison, Stephen C.

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Structural Analysis of Bub3 Interactions in the Mitotic Spindle Checkpoint von Larsen, Nicholas A., Al-Bassam, Jawdat, Wei, Ronnie R., Harrison, Stephen C.

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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay von Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.

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Structure of a Central Component of the Yeast Kinetochore: The Spc24p/Spc25p Globular Domain von Wei, Ronnie R., Schnell, Jason R., Larsen, Nicholas A., Sorger, Peter K., Chou, James J., Harrison, Stephen C.

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Antibody Catalysis of the Oxidation of Water von Wentworth, Paul, Jones, Lyn H., Wentworth, Anita D., Zhu, Xueyong, Larsen, Nicholas A., Wilson, Ian A., Xu, Xin, Goddard, William A., Janda, Kim D., Eschenmoser, Albert, Lerner, Richard A.

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An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode von Larsen, Nicholas A, Nash, Tory J, Morningstar, Marshall, Shapiro, Adam B, Joubran, Camil, Blackett, Carolyn J, Patten, Arthur D, Boriack-Sjodin, P Ann, Doig, Peter

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The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity von Nguyen, Tuong-Vi, Yao, Shihua, Wang, Yahong, Rolfe, Alan, Selvaraj, Anand, Darman, Rachel, Ke, Jiyuan, Warmuth, Markus, Smith, Peter G., Larsen, Nicholas A., Yu, Lihua, Zhu, Ping, Fekkes, Peter, Vaillancourt, Frédéric H., Bolduc, David M.

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists von Hennessy, Edward J., Saeh, Jamal C., Sha, Li, MacIntyre, Terry, Wang, Haiyun, Larsen, Nicholas A., Aquila, Brian M., Ferguson, Andrew D., Laing, Naomi M., Omer, Charles A.

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Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists von Irwin, Sean, Karr, Craig, Furman, Craig, Tsai, Jennifer, Gee, Patricia, Banka, Deepti, Wibowo, Ardian S., Dementiev, Alexey A., O’Shea, Morgan, Yang, Joyce, Lowe, Jason, Mitchell, Lorna, Ruppel, Sabine, Fekkes, Peter, Zhu, Ping, Korpal, Manav, Larsen, Nicholas A.

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Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket von Yao, Shihua, Nguyen, Tuong-Vi, Rolfe, Alan, Agrawal, Anant A., Ke, Jiyuan, Peng, Shouyong, Colombo, Federico, Yu, Sean, Bouchard, Patricia, Wu, Jiayi, Huang, Kuan-Chun, Bao, Xingfeng, Omoto, Kiyoyuki, Selvaraj, Anand, Yu, Lihua, Ioannidis, Stephanos, Vaillancourt, Frédéric H., Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.

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Rapid and Robust Protection against Cocaine-Induced Lethality in Rats by the Bacterial Cocaine Esterase von Cooper, Ziva D, Narasimhan, Diwahar, Sunahara, Roger K, Mierzejewski, Pawel, Jutkiewicz, Emily M, Larsen, Nicholas A, Wilson, Ian A, Landry, Donald W, Woods, James H

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Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors von Cowen, Scott D, Russell, Daniel, Dakin, Leslie A, Chen, Huawei, Larsen, Nicholas A, Godin, Robert, Throner, Scott, Zheng, Xiaolan, Molina, Audrey, Wu, Jiaquan, Cheung, Tony, Howard, Tina, Garcia-Arenas, Renee, Keen, Nicholas, Pendleton, Christopher S, Pietenpol, Jennifer A, Ferguson, Andrew D

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering von Johannes, Jeffrey W., Almeida, Lynsie, Daly, Kevin, Ferguson, Andrew D., Grosskurth, Shaun E., Guan, Huiping, Howard, Tina, Ioannidis, Stephanos, Kazmirski, Steven, Lamb, Michelle L., Larsen, Nicholas A., Lyne, Paul D., Mikule, Keith, Ogoe, Claude, Peng, Bo, Petteruti, Philip, Read, Jon A., Su, Nancy, Sylvester, Mark, Throner, Scott, Wang, Wenxian, Wang, Xin, Wu, Jiaquan, Ye, Qing, Yu, Yan, Zheng, Xiaolan, Scott, David A.

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Crystal structure of a bacterial cocaine esterase von Wilson, Ian A, Larsen, Nicholas A, Turner, James M, Stevens, James, Rosser, Susan J, Basran, Amrik, Lerner, Richard A, Bruce, Neil C

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BluB cannibalizes flavin to form the lower ligand of vitamin B 12 von Walker, Graham C, Taga, Michiko E, Howard-Jones, Annaleise R, Walsh, Christopher T, Larsen, Nicholas A

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