Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications von Sonawane, Ravindra P., Jheengut, Vishal, Rabalakos, Constantinos, Larouche-Gauthier, Robin, Scott, Helen K., Aggarwal, Varinder K.

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CpRh(III)‐Catalyzed C8 C−H Alkylation of Quinoline N‐Oxides with Diazo Meldrum's Acid von Huestis, Malcolm P., Leclerc, Jean‐Philippe, Larouche‐Gauthier, Robin, Aubert‐Nicol, Samuel, Yadav, Arun, Sivamuthuraman, Koilpitchai

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Ate Complexes of Secondary Boronic Esters as Chiral Organometallic-Type Nucleophiles for Asymmetric Synthesis von Larouche-Gauthier, Robin, Elford, Tim G, Aggarwal, Varinder K

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Rapid Assembly of Quinolizidines via Consecutive Nucleophilic Cyclizations onto Activated Amides von Bélanger, Guillaume, O’Brien, Gary, Larouche-Gauthier, Robin

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Asymmetric Total Synthesis of (+)-Virosine A via Sequential Nucleophilic Cyclizations onto an Activated Formamide von Bélanger, Guillaume, Dupuis, Marianne, Larouche-Gauthier, Robin

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Synthesis of the Tricyclic Core of Alkaloid Securinol B Using a Cascade of Vilsmeier−Haack and Mannich Cyclizations von Larouche-Gauthier, Robin, Bélanger, Guillaume

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Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters von Larouche-Gauthier, Robin, Fletcher, Catherine J., Couto, Irantzu, Aggarwal, Varinder K.

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Cover Picture: Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications (Angew. Chem. Int. Ed. 16/2011) von Sonawane, Ravindra P., Jheengut, Vishal, Rabalakos, Constantinos, Larouche-Gauthier, Robin, Scott, Helen K., Aggarwal, Varinder K.

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Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications von Sonawane, Ravindra P., Jheengut, Vishal, Rabalakos, Constantinos, Larouche-Gauthier, Robin, Scott, Helen K., Aggarwal, Varinder K.

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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma von Bronner, Sarah M., Merrick, Karl A., Murray, Jeremy, Salphati, Laurent, Moffat, John G., Pang, Jodie, Sneeringer, Christopher J., Dompe, Nicholas, Cyr, Patrick, Purkey, Hans, Boenig, Gladys de Leon, Li, Jun, Kolesnikov, Aleksandr, Larouche-Gauthier, Robin, Lai, Kwong Wah, Shen, Xiaoli, Aubert-Nicol, Samuel, Chen, Yi-Chen, Cheong, Jonathan, Crawford, James J., Hafner, Marc, Haghshenas, Pouyan, Jakalian, Araz, Leclerc, Jean-Philippe, Lim, Ngiap-Kie, O'Brien, Tom, Plise, Emile G., Shalan, Hadil, Sturino, Claudio, Wai, John, Xiao, Yang, Yin, Jianping, Zhao, Liang, Gould, Stephen, Olivero, Alan, Heffron, Timothy P.

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Titelbild: Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications (Angew. Chem. 16/2011) von Sonawane, Ravindra P., Jheengut, Vishal, Rabalakos, Constantinos, Larouche-Gauthier, Robin, Scott, Helen K., Aggarwal, Varinder K.

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Intramolecular Additions of Various π-Nucleophiles to Chemoselectively Activated Amides and Application to the Synthesis of (±)-Tashiromine von Bélanger, Guillaume, Larouche-Gauthier, Robin, Ménard, Frédéric, Nantel, Miguel, Barabé, Francis

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Cover Feature: CpRh(III)‐Catalyzed C8 C−H Alkylation of Quinoline N‐Oxides with Diazo Meldrum's Acid (Eur. J. Org. Chem. 3/2021) von Huestis, Malcolm P., Leclerc, Jean‐Philippe, Larouche‐Gauthier, Robin, Aubert‐Nicol, Samuel, Yadav, Arun, Sivamuthuraman, Koilpitchai

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Addition of Tethered Nonaromatic Carbon Nucleophiles to Chemoselectively Activated Amides von Bélanger, Guillaume, Larouche-Gauthier, Robin, Ménard, Frédéric, Nantel, Miguel, Barabé, Francis

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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic E... von Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew

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Use of alkyl 2,4,6-triisopropylbenzoates in the asymmetric homologation of challenging boronic esters von Larouche-Gauthier, Robin, Fletcher, Catherine J, Couto, Irantzu, Aggarwal, Varinder K

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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease von Terrett, Jack A., Ly, Justin Q., Katavolos, Paula, Hasselgren, Catrin, Laing, Steven, Zhong, Fiona, Villemure, Elisia, Déry, Martin, Larouche-Gauthier, Robin, Chen, Huifen, Shore, Daniel G., Lee, Wyne P., Suto, Eric, Johnson, Kevin, Brooks, Marjory, Stablein, Alyssa, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Elstrott, Justin, Gandham, Vineela, Joseph, Victory, Booler, Helen, Cain, Gary, Chou, Carolina, Fullerton, Aaron, Lepherd, Michelle, Stainton, Shannon, Torres, Elizabeth, Urban, Konnie, Yu, Lanlan, Zhong, Yu, Bao, Linda, Chou, Kang-Jye, Lin, Jessica, Zhang, Wei, La, Hank, Liu, Liling, Mulder, Teresa, Chen, Jun, Chernov-Rogan, Tania, Johnson, Adam R., Hackos, David H., Leahey, Rebecca, Shields, Shannon D., Balestrini, Alessia, Riol-Blanco, Lorena, Safina, Brian S., Volgraf, Matthew, Magnuson, Steven, Kakiuchi-Kiyota, Satoko

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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists von Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew

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ChemInform Abstract: Prins Cyclization of α-Bromoethers under Basic Conditions von Arpin, Patrice, Hill, Bryan, Larouche-Gauthier, Robin, Spino, Claude

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Optimization of a Novel DEL Hit That Binds in the Cbl‑b SH2 Domain and Blocks Substrate Binding von Liang, Jun, Lambrecht, Michael J., Arenzana, Teresita L., Aubert-Nicol, Samuel, Bao, Linda, Broccatelli, Fabio, Cai, Jianping, Eidenschenk, Celine, Everett, Christine, Garner, Thomas, Gruber, Felix, Haghshenas, Pouyan, Huestis, Malcolm P., Hsu, Peter L., Kou, Ponien, Jakalian, Araz, Larouche-Gauthier, Robin, Leclerc, Jean-Philippe, Leung, Dennis H., Martin, Aaron, Murray, Jeremy, Prangley, Madeleine, Rutz, Sascha, Kakiuchi-Kiyota, Satoko, Satz, Alexander Lee, Skelton, Nicholas J., Steffek, Micah, Stoffler, Daniel, Sudhamsu, Jawahar, Tan, Sophia, Wang, Jian, Wang, Shouliang, Wang, Qiuyue, Wendorff, Timothy J., Wichert, Moreno, Yadav, Arun, Yu, Christine, Wang, Xiaojing

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