Challenge of Atropisomerism in Drug Discovery von Clayden, Jonathan, Moran, Wesley J, Edwards, Paul J, LaPlante, Steven R

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Drug Self-Aggregation into Nano-Entities Has the Potential to Induce Immune Responses von Shahout, Fatma, Vanharen, Marion, Saafane, Abdelaziz, Gillard, James, Girard, Denis, LaPlante, Steven R.

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Assessing Atropisomer Axial Chirality in Drug Discovery and Development von LaPlante, Steven R, D. Fader, Lee, Fandrick, Keith R, Fandrick, Daniel R, Hucke, Oliver, Kemper, Ray, Miller, Stephen P. F, Edwards, Paul J

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Revealing Atropisomer Axial Chirality in Drug Discovery von LaPlante, Steven R., Edwards, Paul J., Fader, Lee D., Jakalian, Araz, Hucke, Oliver

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Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy von Mistretta, Maxime, Cimino, Mena, Campagne, Pascal, Volant, Stevenn, Kornobis, Etienne, Hebert, Olivier, Rochais, Christophe, Dallemagne, Patrick, Lecoutey, Cédric, Tisnerat, Camille, Lepailleur, Alban, Ayotte, Yann, LaPlante, Steven R., Gangneux, Nicolas, Záhorszká, Monika, Korduláková, Jana, Vichier-Guerre, Sophie, Bonhomme, Frédéric, Pokorny, Laura, Albert, Marvin, Tinevez, Jean-Yves, Manina, Giulia

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Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings von Fnaiche, Ahmed, Mélin, Léa, Suárez, Narjara González, Paquin, Alexis, Vu, Victoria, Li, Fengling, Allali-Hassani, Abdellah, Bolotokova, Albina, Allemand, Frédéric, Gelin, Muriel, Cotelle, Philippe, Woo, Simon, LaPlante, Steven R., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Guichou, Jean-François, Annabi, Borhane, Gagnon, Alexandre

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NMR strategies to support medicinal chemistry workflows for primary structure determination von Oguadinma, Paul, Bilodeau, Francois, LaPlante, Steven R.

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Fragment‐Based Phenotypic Lead Discovery: Cell‐Based Assay to Target Leishmaniasis von Ayotte, Yann, Bilodeau, François, Descoteaux, Albert, LaPlante, Steven R.

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Exposing Small-Molecule Nanoentities by a Nuclear Magnetic Resonance Relaxation Assay von Ayotte, Yann, Marando, Victoria M, Vaillancourt, Louis, Bouchard, Patricia, Heffron, Gregory, Coote, Paul W, Larda, Sacha T, LaPlante, Steven R

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NMR spectroscopy can help accelerate antiviral drug discovery programs von LaPlante, Steven R., Coric, Pascale, Bouaziz, Serge, França, Tanos C.C.

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Synthesis of a thiophene-based fluorinated library applied to fragment-based drug discovery via19F NMR with confirmed binding to mutant HRASG12V von Bendahan, David, Franca, Tanos C C, Amiens, Kathleen C, Ayotte, Yann, gione, Pat, LaPlante, Steven R

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A Multi-epitope Vaccine Candidate Against Bolivian Hemorrhagic fever Caused by Machupo Virus von Ali, Zeeshan, Cardoza, Jyothsna Volisha, Basak, Srijita, Narsaria, Utkarsh, Bhattacharjee, Surjit, G., Unnati Meher, Isaac, Samuel Paul, Franca, Tanos C. C., LaPlante, Steven R., George, Sudhan S.

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Probing the free-state solution behavior of drugs and their tendencies to self-aggregate into nano-entities von LaPlante, Steven R., Roux, Valérie, Shahout, Fatma, LaPlante, Gabriela, Woo, Simon, Denk, Maria M., Larda, Sacha T., Ayotte, Yann

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Compound Aggregation in Drug Discovery: Implementing a Practical NMR Assay for Medicinal Chemists von LaPlante, Steven R, Carson, Rebekah, Gillard, James, Aubry, Norman, Coulombe, René, Bordeleau, Sylvain, Bonneau, Pierre, Little, Michael, O’Meara, Jeff, Beaulieu, Pierre L

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Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors von Wypych, Rachel M., LaPlante, Steven R., White, Peter W., Martin, Stephen F.

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Practical Considerations and Guidelines for Spectral Referencing for Fluorine NMR Ligand Screening von Ayotte, Yann, Woo, Simon, LaPlante, Steven R

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Computational assessment of the binding modes of the first VHL-recruiting PROTACs designed for oncogenic KRasG12C von Franca, Tanos C C, Delaire, Eleonore K M, Drummond, Michael, Maximilian C C J C Ebert, Ajamian, Al, LaPlante, Steven R

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Fragment-Based Phenotypic Lead Discovery To Identify New Drug Seeds That Target Infectious Diseases von Ayotte, Yann, Bernet, Eve, Bilodeau, François, Cimino, Mena, Gagnon, Dominic, Lebughe, Marthe, Mistretta, Maxime, Ogadinma, Paul, Ouali, Sarah-Lisa, Sow, Aïssatou Aïcha, Chatel-Chaix, Laurent, Descoteaux, Albert, Manina, Giulia, Richard, Dave, Veyrier, Frédéric, LaPlante, Steven R

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Robust Strategy for Hit-to-Lead Discovery: NMR for SAR von Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.

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N-Phenylpyridine-3-Carboxamide and 6-Acetyl-1H-Indazole Inhibit the RNA Replication Step of the Dengue Virus Life Cycle von Sow, Aïssatou Aïcha, Pahmeier, Felix, Ayotte, Yann, Anton, Anaïs, Mazeaud, Clément, Charpentier, Tania, Angelo, Léna, Woo, Simon, Cerikan, Berati, Falzarano, Darryl, Abrahamyan, Levon, Lamarre, Alain, Labonté, Patrick, Cortese, Mirko, Bartenschlager, Ralf, LaPlante, Steven R, Chatel-Chaix, Laurent

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