Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function von Bian, Zehua, Wang, Qiang, Zhou, Xinyu, Tan, Tao, Park, Ki Ho, Kramer, H. Fritz, McDougal, Alan, Laping, Nicholas J., Kumar, Sanjay, Adesanya, T. M. Ayodele, Sermersheim, Matthew, Yi, Frank, Wang, Xinxin, Wu, Junwei, Gumpper, Kristyn, Jiang, Qiwei, He, Duofen, Lin, Pei-Hui, Li, Haichang, Guan, Fangxia, Zhou, Jingsong, Kohr, Mark J., Zeng, Chunyu, Zhu, Hua, Ma, Jianjie

Volltext

PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome von Grande, Valentina, Ornaghi, Francesca, Comerio, Liliana, Restelli, Elena, Masone, Antonio, Corbelli, Alessandro, Tolomeo, Daniele, Capone, Vanessa, Axten, Jeffrey M, Laping, Nicholas J, Fiordaliso, Fabio, Sallese, Michele, Chiesa, Roberto

Volltext

Development of a Small-Molecule Serum-and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic von SHERK, Andrea B, FRIGO, Daniel E, NORRIS, John D, MCDONNELL, Donald P, SCHNACKENBERG, Christine G, BRAY, Jeffrey D, LAPING, Nicholas J, TRIZNA, Walter, HAMMOND, Marlys, PATTERSON, Jaclyn R, THOMPSON, Scott K, KAZMIN, Dmitri

Volltext

AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome von Lashinger, Erin S. R, Steiginga, Matthew S, Hieble, J. Paul, Leon, Lisa A, Gardner, Scott D, Nagilla, Rakesh, Davenport, Elizabeth A, Hoffman, Bryan E, Laping, Nicholas J, Su, Xin

Volltext

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 von Inman, Gareth J, Nicolás, Francisco J, Callahan, James F, Harling, John D, Gaster, Laramie M, Reith, Alastair D, Laping, Nicholas J, Hill, Caroline S

Volltext

SB-505124 Is a Selective Inhibitor of Transforming Growth Factor-β Type I Receptors ALK4, ALK5, and ALK7 von DaCosta Byfield, Stacey, Major, Christopher, Laping, Nicholas J., Roberts, Anita B.

Volltext

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy von Koren, Shon A, Hamm, Matthew J, Cloyd, Ryan, Fontaine, Sarah N, Chishti, Emad, Lanzillotta, Chiara, Rodriguez-Rivera, Jennifer, Ingram, Alexandria, Bell, Michelle, Galvis-Escobar, Sara M, Zulia, Nicholas, Di Domenico, Fabio, Duong, Duc, Seyfried, Nicholas T, Powell, David, Vandsburger, Moriel, Frolinger, Tal, Hartz, Anika M S, Koren, 3rd, John, Axten, Jeffrey M, Laping, Nicholas J, Abisambra, Jose F

Volltext

A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator von Madauss, Kevin P, Grygielko, Eugene T, Deng, Su-Jun, Sulpizio, Anthony C, Stanley, Thomas B, Wu, Charlene, Short, Steve A, Thompson, Scott K, Stewart, Eugene L, Laping, Nicholas J, Williams, Shawn P, Bray, Jeffrey D

Volltext

Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria von Wang, Amy, Ziyadeh, Fuad N, Lee, Eun Young, Pyagay, Petr E, Sung, Sun Hee, Sheardown, Steven A, Laping, Nicholas J, Chen, Sheldon

Volltext

SB-431542, a small molecule transforming growth factor-β-receptor antagonist, inhibits human glioma cell line proliferation and motility von Hjelmeland, Mark D, Hjelmeland, Anita B, Sathornsumetee, Sith, Reese, Elizabeth D, Herbstreith, Michael H, Laping, Nicholas J, Friedman, Henry S, Bigner, Darell D, Wang, Xiao-Fan, Rich, Jeremy N

Volltext

Tumor-Specific Efficacy of Transforming Growth Factor-βRI Inhibition in Eker Rats von LAPING, Nicholas J, EVERITT, Jeffrey I, FRAZIER, Kendall S, BURGERT, Mark, PORTIS, Melisa J, CADACIO, Caprice, GOLD, Leslie I, WALKER, Cheryl L

Volltext

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5) von Callahan, James F, Burgess, Joelle L, Fornwald, James A, Gaster, Laramie M, Harling, John D, Harrington, Frank P, Heer, Jag, Kwon, Chet, Lehr, Ruth, Mathur, A, Olson, Barbara A, Weinstock, Joseph, Laping, Nicholas J

Volltext

Tgf-β3-induced palatal fusion is mediated by Alk-5/Smad pathway von Dudas, Marek, Nagy, Andre, Laping, Nicholas J, Moustakas, Aristidis, Kaartinen, Vesa

Volltext

Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice von McCafferty, Gerald P, Misajet, Blake A, Laping, Nicholas J, Edwards, Richard M, Thorneloe, Kevin S

Volltext

Discovery of 4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388):  A Potent, Selective, and Orally Active Transforming Growth Fac... von Gellibert, Françoise, de Gouville, Anne-Charlotte, Woolven, James, Mathews, Neil, Nguyen, Van-Loc, Bertho-Ruault, Cécile, Patikis, Angela, Grygielko, Eugene T, Laping, Nicholas J, Huet, Stéphane

Volltext

Effects of Rho-kinase inhibition on myosin light chain phosphorylation and obstruction-induced detrusor overactivity von Marx, James O, Basha, Maureen E, Mohanan, Sunish, Hypolite, Joseph A, Chang, Shaohua, Wein, Alan J, Zderic, Stephen A, Laping, Nicholas J, Chacko, Samuel

Volltext

Modulation of bladder function by prostaglandin EP3 receptors in the central nervous system von Su, Xin, Leon, Lisa A, Wu, Charlene W, Morrow, Dwight M, Jaworski, Jon-Paul, Hieble, J. Paul, Lashinger, Erin S. R, Jin, Jian, Edwards, Richard M, Laping, Nicholas J

Volltext

Estrogen-induced stromal cell-derived factor-1 (SDF-1/ Cxcl12) expression is repressed by progesterone and by Selective Estrogen Receptor Modulators via estrogen receptor α in rat... von Glace, Lindsay, Grygielko, Eugene T., Boyle, Ryan, Wang, Qi, Laping, Nicholas J., Sulpizio, Anthony C., Bray, Jeffrey D.

Volltext

TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis von Laping, Nicholas J., DeMartino, Michael P., Cottom, Joshua E., Axten, Jeffrey M., Emery, John G., Guss, Jeffrey H., Burman, Miriam, Foley, James J., Cheung, Mui, Oliff, Allen, Kumar, Sanjay

Volltext

An excitatory role for peripheral EP3 receptors in bladder afferent function von Su, Xin, Lashinger, Erin S. R, Leon, Lisa A, Hoffman, Bryan E, Hieble, J. Paul, Gardner, Scott D, Fries, Harvey E, Edwards, Richard M, Li, Jun, Laping, Nicholas J

Volltext