PROTAC targeted protein degraders: the past is prologue von Békés, Miklós, Langley, David R., Crews, Craig M.

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A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling von Ni, Shengyang, Garrido‐Castro, Alberto F., Merchant, Rohan R., de Gruyter, Justine N., Schmitt, Daniel C., Mousseau, James J., Gallego, Gary M., Yang, Shouliang, Collins, Michael R., Qiao, Jennifer X., Yeung, Kap‐Sun, Langley, David R., Poss, Michael A., Scola, Paul M., Qin, Tian, Baran, Phil S.

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Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry von Lai, Yen-Ting, Wang, Tao, O’Dell, Sijy, Louder, Mark K., Schön, Arne, Cheung, Crystal S. F., Chuang, Gwo-Yu, Druz, Aliaksandr, Lin, Bob, McKee, Krisha, Peng, Dongjun, Yang, Yongping, Zhang, Baoshan, Herschhorn, Alon, Sodroski, Joseph, Bailer, Robert T., Doria-Rose, Nicole A., Mascola, John R., Langley, David R., Kwong, Peter D.

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The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors von Lambert, Sebastian M., Langley, David R., Garnett, James A., Angell, Richard, Hedgethorne, Katy, Meanwell, Nicholas A., Matthews, Steve J.

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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core von Sivaprakasam, Prasanna, Han, Xiaojun, Civiello, Rita L, Jacutin-Porte, Swanee, Kish, Kevin, Pokross, Matt, Lewis, Hal A, Ahmed, Nazia, Szapiel, Nicolas, Newitt, John A, Baldwin, Eric T, Xiao, Hong, Krause, Carol M, Park, Hyunsoo, Nophsker, Michelle, Lippy, Jonathan S, Burton, Catherine R, Langley, David R, Macor, John E, Dubowchik, Gene M

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Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action von Langley, David R., Roy Kimura, S., Sivaprakasam, Prasanna, Zhou, Nannan, Dicker, Ira, McAuliffe, Brian, Wang, Tao, Kadow, John F., Meanwell, Nicholas A., Krystal, Mark

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Inhibition of Hepatitis B Virus Polymerase by Entecavir von LANGLEY, David R, WALSH, Ann W, BALDICK, Carl J, EGGERS, Betsy J, ROSE, Ronald E, LEVINE, Steven M, JAYNE KAPUR, A, COLONNO, Richard J, TENNEY, Daniel J

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Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development von Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

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Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir von Walsh, Ann W, Langley, David R, Colonno, Richard J, Tenney, Daniel J

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Inhibitors of HIV‑1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir von Meanwell, Nicholas A, Krystal, Mark R, Nowicka-Sans, Beata, Langley, David R, Conlon, David A, Eastgate, Martin D, Grasela, Dennis M, Timmins, Peter, Wang, Tao, Kadow, John F

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Expanding GPCR homology model binding sites via a balloon potential: A molecular dynamics refinement approach von Kimura, S. Roy, Tebben, Andrew J., Langley, David R.

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In Vivo Patterns of Resistance to the HIV Attachment Inhibitor BMS-488043 von NANNAN ZHOU, NOWICKA-SANS, Beata, KADOW, John, GRASELA, Dennis, HANNA, George J, ALEXANDER, Louis, COLONNO, Richard, KRYSTAL, Mark, LIN, Pin-Fang, SHARON ZHANG, LI FAN, JIE FANG, HUA FANG, GONG, Yi-Fei, EGGERS, Betsy, LANGLEY, David R, TAO WANG

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Biochemical and Genetic Characterizations of a Novel Human Immunodeficiency Virus Type 1 Inhibitor That Blocks gp120-CD4 Interactions von Guo, Qi, Ho, Hsu-Tso, Dicker, Ira, Fan, Li, Zhou, Nannan, Friborg, Jacques, Wang, Tao, McAuliffe, Brian V, Wang, Hwei-Gene Heidi, Rose, Ronald E, Fang, Hua, Scarnati, Helen T, Langley, David R, Meanwell, Nicholas A, Abraham, Ralph, Colonno, Richard J, Lin, Pin-Fang

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect von Meanwell, Nicholas A, Gao, Min, Nettles, Richard E, Belema, Makonen, Snyder, Lawrence B, Nguyen, Van N, Fridell, Robert A, Serrano-Wu, Michael H, Langley, David R, Sun, Jin-Hua, O’Boyle II, Donald R, Lemm, Julie A, Wang, Chunfu, Knipe, Jay O, Chien, Caly, Colonno, Richard J, Grasela, Dennis M, Hamann, Lawrence G

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Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529 von Pancera, Marie, Lai, Yen-Ting, Bylund, Tatsiana, Druz, Aliaksandr, Narpala, Sandeep, O'Dell, Sijy, Schön, Arne, Bailer, Robert T, Chuang, Gwo-Yu, Geng, Hui, Louder, Mark K, Rawi, Reda, Soumana, Djade I, Finzi, Andrés, Herschhorn, Alon, Madani, Navid, Sodroski, Joseph, Freire, Ernesto, Langley, David R, Mascola, John R, McDermott, Adrian B, Kwong, Peter D

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Targeting a Binding Pocket within the Trimer-of-Hairpins: Small-Molecule Inhibition of Viral Fusion von Cianci, Christopher, Langley, David R., Dischino, Douglas D., Sun, Yaxiong, Yu, Kuo-Long, Stanley, Anne, Roach, Julia, Li, Zhufang, Dalterio, Richard, Colonno, Richard, Meanwell, Nicholas A., Krystal, Mark, Palese, Peter

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Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors von Dicker, Ira B., Samanta, Himadri K., Li, Zhufang, Hong, Yang, Tian, Yuan, Banville, Jacques, Remillard, Roger R., Walker, Michael A., Langley, David R., Krystal, Mark

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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules von Hickey, Christopher M., Digianantonio, Katherine M., Zimmermann, Kurt, Harbin, Alicia, Quinn, Connor, Patel, Avani, Gareiss, Peter, Chapman, Amanda, Tiberi, Bernadette, Dobrodziej, Jennifer, Corradi, John, Cacace, Angela M., Langley, David R., Békés, Miklós

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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors von Luo, Guanglin, Chen, Ling, Burton, Catherine R, Xiao, Hong, Sivaprakasam, Prasanna, Krause, Carol M, Cao, Yang, Liu, Nengyin, Lippy, Jonathan, Clarke, Wendy J, Snow, Kimberly, Raybon, Joseph, Arora, Vinod, Pokross, Matt, Kish, Kevin, Lewis, Hal A, Langley, David R, Macor, John E, Dubowchik, Gene M

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors von Li, Guo, Meanwell, Nicholas A, Krystal, Mark R, Langley, David R, Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A, Ng, Alicia, Trainor, George L, Cianci, Christopher, Dicker, Ira B, Walker, Michael A, Lin, Zeyu, Protack, Tricia, Discotto, Linda, Jenkins, Susan, Gerritz, Samuel W, Pendri, Annapurna

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