Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors von Calandrini, Camilla, van Hooff, Sander R., Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M., Langenberg, Karin P.S., van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R., Tytgat, Godelieve A.M., van den Heuvel-Eibrink, Marry M., Molenaar, Jan J., Drost, Jarno

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P316: PRIORITIZING PRECISION MEDICINES IN PEDIATRIC BLOOD CANCER: EXPERIENCE OF THE DUTCH INDIVIDUALIZED THERAPY (ITHER) STUDY’S MOLECULAR TUMOR BOARD von Boer, Judith M., Ilan, Uri, Hoen, Babette D.J., Boeree, Aurelie, Langenberg, Karin P.S., Koster, Jan, Bourquin, Jean‐Pierre, Molenaar, Jan J., Goemans, Bianca, Den Boer, Monique L., Zwaan, Michel

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Paternal exposure to recreational drugs before conception and its effect on live‐born offspring: A scoping review von Verstegen, Ruud H.J., Wang, Guo, Langenberg‐Ververgaert, Karin P.S., Ren, Lily Yuxi, Nulman, Irena

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The Landscape of Pediatric Precision Oncology: Program Design, Actionable Alterations, and Clinical Trial Development von Langenberg, Karin P S, Looze, Eleonora J, Molenaar, Jan J

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The potential of PARP as a therapeutic target across pediatric solid malignancies von Keller, Kaylee M, Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L, Langenberg, Karin P S, Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M Emmy M, Molenaar, Jan J, van Hooff, Sander R

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Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes von Meister, Michael T, Groot Koerkamp, Marian J A, de Souza, Terezinha, Breunis, Willemijn B, Frazer‐Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H D, Janse, Alex, Dolman, M Emmy M, Eising, Selma, Langenberg, Karin P S, van Tuil, Marc, Knops, Rutger R G, van Scheltinga, Sheila Terwisscha, Hiemcke‐Jiwa, Laura S, Flucke, Uta, Merks, Johannes H M, van Noesel, Max M, Tops, Bastiaan B J, Hehir‐Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C P

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Myeloproliferative Neoplasm Driven by ETV6-ABL1 in an Adolescent with Recent History of Burkitt Leukemia von Renzi, Samuele, Algawahmed, Fatimah, Davidson, Scott, Langenberg, Karin P S, Fuligni, Fabio, Ali, Salah, Anderson, Nathaniel, Brunga, Ledia, Bartram, Jack, Abdelhaleem, Mohamed, Naqvi, Ahmed, Beimnet, Kassa, Schuh, Andre, Tierens, Anne, Malkin, David, Shlien, Adam, Shago, Mary, Villani, Anita

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The potential of PARP as a therapeutic target across pediatric solid malignancies von Keller, Kaylee M, Koetsier, Joost, Schild, Linda, Amo-Addae, Vicky, Eising, Selma, van den Handel, Kim, Ober, Kimberley, Koopmans, Bianca, Essing, Anke, van den Boogaard, Marlinde L, Langenberg, Karin P.S, Jäger, Natalie, Kool, Marcel, Pfister, Stefan, Dolman, M. Emmy M, Molenaar, Jan J, van Hooff, Sander R

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Case series on clinical applications of liquid biopsy in pediatric solid tumors: towards improved diagnostics and disease monitoring von Gelineau, Nina U, van Barneveld, Astrid, Samim, Atia, Van Zogchel, Lieke, Lak, Nathalie, Tas, Michelle L, Matser, Yvette, Mavinkurve-Groothuis, Annelies M C, van Grotel, Martine, Zsiros, Jószef, van Eijkelenburg, Natasha K A, Knops, Rutger R G, van Ewijk, Roelof, Langenberg, Karin P S, Krijger, Ronald De, Hiemcke-Jiwa, Laura S, Van Paemel, Ruben, Cornelli, Lotte, De Preter, Katleen, De Wilde, Bram, Van Der Schoot, Ellen, Tytgat, Godelieve

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Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm von Bakhuizen, Jette J, Hopman, Saskia M J, Bosscha, Machteld I, Dommering, Charlotte J, van den Heuvel-Eibrink, Marry M, Hol, Janna A, Kester, Lennart A, Koudijs, Marco J, Langenberg, Karin P S, Loeffen, Jan L C, van der Lugt, Jasper, Moll, Annette C, van Noesel, Max M, Smetsers, Stephanie E, de Vos-Kerkhof, Evelien, Merks, Johannes H M, Kuiper, Roland P, Jongmans, Marjolijn C J

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The pediatric precision oncology study INFORM: Clinical outcome and benefit for molecular subgroups von van Tilburg, Cornelis Martinus, Pfaff, Elke, Pajtler, Kristian W., Langenberg, Karin P.S., Fiesel, Petra, Jones, Barbara C., Balasubramanian, Gnana Prakash, Stark, Sebastian, Johann, Pascal D., Blattner-Johnson, Mirjam, Schramm, Kathrin, Jäger, Natalie, von Deimling, Andreas, Dirksen, Uta, Freitag, Angelika, Witt, Ruth, Lichter, Peter, Jones, David T.W., Pfister, Stefan M., Witt, Olaf

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Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’ von Langenberg, Karin P.S, Meister, Michael T, Bakhuizen, Jette J, Boer, Judith M, van Eijkelenburg, Natasha K.A, Hulleman, Esther, Ilan, Uri, Looze, Eleonora J, Dierselhuis, Miranda P, van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G, Ober, Kimberley, van Hooff, Sander R, Scheijde-Vermeulen, Marijn A, Hiemcke-Jiwa, Laura S, Flucke, Uta E, Kranendonk, Mariette E.G, Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P, Volckmann, Richard, Hehir-Kwa, Jayne Y, Kester, Lennart A, Koudijs, Marco M.J, Waanders, Esme, Holstege, Frank C.P, Vormoor, H. Josef, Hoving, Eelco W, van Noesel, Max M, Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P, Van Tilburg, Cornelis M, Jones, Barbara C, Jones, David T.W, Witt, Olaf, Pfister, Stefan M, Jongmans, Marjolijn C.J, Kuiper, Roland P, de Krijger, Ronald R, Wijnen, Marc H.W, den Boer, Monique L, Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J, Goemans, Bianca F, Molenaar, Jan J

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mRNA Expression Level of ALK in Neuroblastoma Is Associated with Histological Subtype, ALK Mutations and ALK Immunohistochemical Protein Expression von Bruinsma, Rixt S, Fiocco, Marta F, de Leng, Wendy W.J, Kester, Lennart A, Langenberg, Karin P.S, Tytgat, Godelieve A.M, van Noesel, Max M, Wijnen, Marc H.W.A, van der Steeg, Alida F.W, de Krijger, Ronald R

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Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience von Boer, Judith M, Ilan, Uri, Boeree, Aurélie, Langenberg, Karin P.S, Koster, Jan, Koudijs, Marco J, Hehir-Kwa, Jayne Y, Rossi, Corinne, Nierkens, Stefan, Molenaar, Jan J, Goemans, Bianca F, den Boer, Monique L, Zwaan, C. Michel

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Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors von Calandrini, Camilla, van Hooff, Sander R, Paassen, Irene, Ayyildiz, Dilara, Derakhshan, Sepide, Dolman, M. Emmy M, Langenberg, Karin P.S, van de Ven, Marieke, de Heus, Cecilia, Liv, Nalan, Kool, Marcel, de Krijger, Ronald R, Tytgat, Godelieve A.M, van den Heuvel-Eibrink, Marry M, Molenaar, Jan J, Drost, Jarno

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Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes von Meister, Michael T, Groot Koerkamp, Marian J.A, de Souza, Terezinha, Breunis, Willemijn B, Frazer-Mendelewska, Ewa, Brok, Mariël, DeMartino, Jeff, Manders, Freek, Calandrini, Camilla, Kerstens, Hinri H.D, Janse, Alex, Dolman, M. Emmy M, Eising, Selma, Langenberg, Karin P.S, van Tuil, Marc, Knops, Rutger R.G, van Scheltinga, Sheila Terwisscha, Hiemcke-Jiwa, Laura S, Flucke, Uta, Merks, Johannes H.M, van Noesel, Max M, Tops, Bastiaan B.J, Hehir-Kwa, Jayne Y, Kemmeren, Patrick, Molenaar, Jan J, van de Wetering, Marc, van Boxtel, Ruben, Drost, Jarno, Holstege, Frank C.P

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Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell von Kildisiute, Gerda, Kholosy, Waleed M, Young, Matthew D, Roberts, Kenny, Elmentaite, Rasa, van Hooff, Sander R, Pacyna, Clarissa N, Khabirova, Eleonora, Piapi, Alice, Thevanesan, Christine, Bugallo-Blanco, Eva, Burke, Christina, Mamanova, Lira, Keller, Kaylee M, Langenberg-Ververgaert, Karin P S, Lijnzaad, Philip, Margaritis, Thanasis, Holstege, Frank C P, Tas, Michelle L, Wijnen, Marc H W A, van Noesel, Max M, Del Valle, Ignacio, Barone, Giuseppe, van der Linden, Reinier, Duncan, Catriona, Anderson, John, Achermann, John C, Haniffa, Muzlifah, Teichmann, Sarah A, Rampling, Dyanne, Sebire, Neil J, He, Xiaoling, de Krijger, Ronald R, Barker, Roger A, Meyer, Kerstin B, Bayraktar, Omer, Straathof, Karin, Molenaar, Jan J, Behjati, Sam

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Outcome of Children and Adolescents With Relapsed/Refractory/Progressive Malignancies Treated With Molecularly Informed Targeted Drugs in the Pediatric Precision Oncology Registry... von Heipertz, AE, Pajtler, KW, Pfaff, E, Schramm, K, Blattner-Johnson, M, Milde, T, Jones, BC, Zuliani, C, Hutter, C, Lohi, O, Kattamis, A, Dachowska-Kalwak, I, Nilsson, A, Gerber, NU, Langenberg, KPS, Goemans, B, Zwaan, CM, Molenaar, JJ, Jager, N, Dirksen, U, Witt, R, Pfister, SM, Jones, DTW, Kopp-Schneider, A, Witt, O, van Tilburg, CM

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Assessment of Cancer Predisposition Syndromes in a National Cohort of Children With a Neoplasm von Bakhuizen, Jette J, Hopman, Saskia M.J, Bosscha, Machteld I, Dommering, Charlotte J, van den Heuvel-Eibrink, Marry M, Hol, Janna A, Kester, Lennart A, Koudijs, Marco J, Langenberg, Karin P.S, Loeffen, Jan L.C, van der Lugt, Jasper, Moll, Annette C, van Noesel, Max M, Smetsers, Stephanie E, de Vos-Kerkhof, Evelien, Merks, Johannes H.M, Kuiper, Roland P, Jongmans, Marjolijn C.J

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Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma von Langenberg-Ververgaert, Karin P S, Laxer, Ronald M, Punnett, Angela S, Dupuis, L Lee, Finkelstein, Yaron, Abla, Oussama

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