Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist von Mowbray, Charles E., Bell, Andrew S., Clarke, Nicholas P., Collins, Michelle, Jones, Rhys M., Lane, Charlotte A.L., Liu, Wai L., Newman, Sandra D., Paradowski, Michael, Schenck, Emanuel J., Selby, Mathew D., Swain, Nigel A., Williams, David H.

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Synthesis of novel histamine H4 receptor antagonists von Lane, Charlotte A.L., Hay, Duncan, Mowbray, Charles E., Paradowski, Michael, Selby, Matthew D., Swain, Nigel A., Williams, David H.

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1 A mouse model highlights a role for p53 in 5q− syndrome von Barlow, J.L, Drynan, L.F, Trim, N.L, Hewett, D.R, Holmes, L.R, Lorenzo-Abalde, S, Lane, A.L, John, H.E, Pannell, R, Wong, S.H, Warren, A.J, Erber, W.N, Wainscoat, J.S, Boultwood, J, McKenzie, A.N

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Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals? von te Lintel Hekkert, Maaike, Newton, Gary, Chapman, Kathryn, Aqil, Rehan, Downham, Robert, Yan, Robert, Merkus, Daphne, Whitlock, Gavin, Lane, Charlotte A. L., Cawkill, Darren, Perrior, Trevor, Duncker, Dirk J., Schneider, Michael D.

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Structure–activity relationship of chemical defenses from the freshwater plant Micranthemum umbrosum von Lane, Amy L., Kubanek, Julia

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Inhalation by Design: Novel Ultra-Long-Acting β2-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfona... von Glossop, Paul A, Lane, Charlotte A. L, Price, David A, Bunnage, Mark E, Lewthwaite, Russell A, James, Kim, Brown, Alan D, Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A, Clarke, Nicholas P, Webster, Robert, Jones, Rhys M, Burrows, Jane L, Feeder, Neil, Taylor, Stefan C. J, Spence, Fiona J

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Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain von Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.

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The discovery of long acting β2-adrenoreceptor agonists von BROWN, Alan D, BUNNAGE, Mark E, TREVETHICK, Mike, WEBSTER, Rob, GLOSSOP, Paul A, JAMES, Kim, JONES, Rhys, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A

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The discovery of adamantyl-derived, inhaled, long acting β2-adrenoreceptor agonists von BROWN, Alan D, BUNNAGE, Mark E, TREVETHICK, Mike, WEBSTER, Rob, GLOSSOP, Paul A, JAMES, Kim, JONES, Rhys, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A

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A Novel Series of Potent and Selective PDE5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability von Allerton, Charlotte M. N, Barber, Christopher G, Beaumont, Kevin C, Brown, David G, Cole, Susan M, Ellis, David, Lane, Charlotte A. L, Maw, Graham N, Mount, Natalie M, Rawson, David J, Robinson, Colin M, Street, Stephen D. A, Summerhill, Nicholas W

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The eccentric Saturnian ringlets at 1.29Rs and 1.45Rs von Porco, C., Nicholson, P.D., Borderies, N., Danielson, G.E., Goldreich, P., Holdberg, J.B., Lane, A.L.

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Exploring the Universe with the IUE Satellite von Kondo, Y, Wamsteker, Willem, Boggess, A, Grewing, M, de Jager, C, Lane, A. L, Linsky, Jeffrey L, Wilson, R

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The discovery of indole-derived long acting β2-adrenoceptor agonists for the treatment of asthma and COPD von BROWN, Alan D, BUNNAGE, Mark E, WEBSTER, Rob, GLOSSOP, Paul A, HOLBROOK, Mark, JONES, Rhys D, LANE, Charlotte A. L, LEWTHWAITE, Russell A, MANTELL, Simon, PERROS-HUGUET, Christelle, PRICE, David A

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Europa: Disk-Resolved Ultraviolet Measurements Using the Galileo Ultraviolet Spectrometer von Hendrix, A.R., Barth, C.A., Hord, C.W., Lane, A.L.

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The discovery of adamantyl-derived, inhaled, long acting β 2-adrenoreceptor agonists von Brown, Alan D., Bunnage, Mark E., Glossop, Paul A., James, Kim, Jones, Rhys, Lane, Charlotte A.L., Lewthwaite, Russell A., Mantell, Simon, Perros-Huguet, Christelle, Price, David A., Trevethick, Mike, Webster, Rob

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Mariner 9 ultraviolet spectrometer experiment: Mars airglow spectroscopy and variations in Lyman alpha von Barth, C.A., Stewart, A.I., Hord, C.W., Lane, A.L.

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The Mars Oxidant experiment (MOx) for Mars '96 von McKay, Christopher P., Grunthaner, F.J., Lane, A.L., Herring, M., Bartman, R.K., Ksendzov, A., Manning, C.M., Lamb, J.L., Williams, R.M., Ricco, A.J., Butler, M.A., Murray, B.C., Quinn, R.C., Zent, A.P., Klein, H.P., Levin, G.V.

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The discovery of indole-derived long acting β 2-adrenoceptor agonists for the treatment of asthma and COPD von Brown, Alan D., Bunnage, Mark E., Glossop, Paul A., Holbrook, Mark, Jones, Rhys D., Lane, Charlotte A.L., Lewthwaite, Russell A., Mantell, Simon, Perros-Huguet, Christelle, Price, David A., Webster, Rob

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The discovery of long acting β 2-adrenoreceptor agonists von Brown, Alan D., Bunnage, Mark E., Glossop, Paul A., James, Kim, Jones, Rhys, Lane, Charlotte A.L., Lewthwaite, Russell A., Mantell, Simon, Perros-Huguet, Christelle, Price, David A., Trevethick, Mike, Webster, Rob

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Galileo Ultraviolet Spectrometer experiment von Hord, C. W., Mcclintock, W. E., Stewart, A. I. F., Barth, C. A., Esposito, L. W., Thomas, G. E., Sandel, B. R., Hunten, D. M., Broadfoot, A. L., Shemansky, D. E.

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