Alix Arrives Late During HIV-1 Assembly von Ku, Pei-I, Landesman, Michael L., Saffarian, Saveez

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Proton Permeability of HIV Virus like Particles and Vesicular Stomatitis Virus von Ku, Pei-I, Hodges, Jefferey, Landesman, Michael L., Williams, Peter, Tang, Xiaolin, Saffarian, Saveez

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Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias von Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo

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Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma von Chari, Ajai, Vogl, Dan T, Gavriatopoulou, Maria, Nooka, Ajay K, Yee, Andrew J, Huff, Carol A, Moreau, Philippe, Dingli, David, Cole, Craig, Lonial, Sagar, Dimopoulos, Meletios, Stewart, A. Keith, Richter, Joshua, Vij, Ravi, Tuchman, Sascha, Raab, Marc S, Weisel, Katja C, Delforge, Michel, Cornell, Robert F, Kaminetzky, David, Hoffman, James E, Costa, Luciano J, Parker, Terri L, Levy, Moshe, Schreder, Martin, Meuleman, Nathalie, Frenzel, Laurent, Mohty, Mohamad, Choquet, Sylvain, Schiller, Gary, Comenzo, Raymond L, Engelhardt, Monika, Illmer, Thomas, Vlummens, Philip, Doyen, Chantal, Facon, Thierry, Karlin, Lionel, Perrot, Aurore, Podar, Klaus, Kauffman, Michael G, Shacham, Sharon, Li, Lingling, Tang, Shijie, Picklesimer, Carla, Saint-Martin, Jean-Richard, Crochiere, Marsha, Chang, Hua, Parekh, Samir, Landesman, Yosef, Shah, Jatin, Richardson, Paul G, Jagannath, Sundar

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A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma von Lassman, Andrew B, Wen, Patrick Y, van den Bent, Martin J, Plotkin, Scott R, Walenkamp, Annemiek M E, Green, Adam L, Li, Kai, Walker, Christopher J, Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J, Califano, Andrea, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Mau-Sørensen, Morten

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Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents von Kashyap, Trinayan, Argueta, Christian, Unger, Thaddeus, Klebanov, Boris, Debler, Sophia, Senapedis, William, Crochiere, Marsha L, Lee, Margaret S, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

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XPO1 Target Occupancy Measurements Using Fluorescence Cross Correlation Spectroscopy Support the Selinexor Recommended Phase 2 Dose von Crochiere, Marsha L., Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Kauffman, Michael, Landesman, Yosef

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A Phase 2 Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma von Lassman, Andrew B., Wen, Patrick Y., van den Bent, Martin, Plotkin, Scott R., Walenkamp, Annemiek M. E., Green, Adam L., Li, Kai, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J., Califano, Andrea, Landesman, Yosef, Kauffman, Michael G., Shacham, Sharon, Mau-Soerensen, Morten

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XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose von Crochiere, Marsha L, Hannus, Stefan, Hansen, Kerrin, Becker, Frank, Baloglu, Erkan, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

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A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds von Crochiere, Marsha L, Baloglu, Erkan, Klebanov, Boris, Donovan, Scott, Del Alamo, Diego, Lee, Margaret, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

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Combination Therapy of Selinexor with Bortezomib or Carfilzomib Overcomes Drug Resistance to Proteasome Inhibitors (PI) in Human Multiple Myeloma von Sullivan, Daniel M, Kashyap, Trinayan, Dawson, Jana L, Landesman, Yosef, Grant, Steven, Shain, Kenneth H., Dai, Yun, Kauffman, Michael, Shacham, Sharon, Turner, Joel G

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Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma von Chari, Ajai, Vogl, Dan T, Gavriatopoulou, Maria, Nooka, Ajay K, Yee, Andrew J, Huff, Carol A, Moreau, Philippe, Dingli, David, Cole, Craig, Lonial, Sagar, Dimopoulos, Meletios, Stewart, A. Keith, Richter, Joshua, Vij, Ravi, Tuchman, Sascha, Raab, Marc S, Weisel, Katja C, Delforge, Michel, Cornell, Robert F, Kaminetzky, David, Hoffman, James E, Costa, Luciano J, Parker, Terri L, Levy, Moshe, Schreder, Martin, Meuleman, Nathalie, Frenzel, Laurent, Mohty, Mohamad, Choquet, Sylvain, Schiller, Gary, Comenzo, Raymond L, Engelhardt, Monika, Illmer, Thomas, Vlummens, Philip, Doyen, Chantal, Facon, Thierry, Karlin, Lionel, Perrot, Aurore, Podar, Klaus, Kauffman, Michael G, Shacham, Sharon, Li, Lingling, Tang, Shijie, Picklesimer, Carla, Saint-Martin, Jean-Richard, Crochiere, Marsha, Chang, Hua, Parekh, Samir, Landesman, Yosef, Shah, Jatin, Richardson, Paul G, Jagannath, Sundar

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Preliminary phase II results of selinexor, an oral selective inhibitor of nuclear export in patients with heavily pretreated gynecological cancers von Vergote, Ignace, Lund, Bente, Havsteen, Hanne, Ujmajuridze, Zaza, Leunen, Karin, Aaquist Haslund, Charlotte, Juhler-Noettrup, Trine, Roed, Henrik, Rashal, Tami, Kranich, Anne L., Landesman, Yosef, Saint-Martin, Jean-Richard, Carlson, Robert, Shacham, Sharon, Kauffman, Michael, Mirza, Mansoor Raza

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Abstract 3810: Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo von Crochiere, Marsha L., Kashyap, Trinayan, Klebanov, Boris, Senapedis, William, Alamo, Diego del, Tamir, Sharon, Baloglu, Erkan, McCauley, Dilara, Carlson, Robert, Kauffman, Michael, Shacham, Sharon, Demetri, George, Wagner, Andrew, Sicinska, Ewa, Gokhale, Prafulla, Kohl, Nancy, Saur, Amy, Landesman, Yosef

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A first-in-class, first-in-human phase I trial of KPT-330 (selinexor), a selective inhibitor of nuclear export (SINE) in patients (pts) with advanced solid tumors von Mau-Soerensen, Morten, Razak, Albiruni R. A., Shields, Anthony Frank, Gabrail, Nashat Y., Gerecitano, John F., Shacham, Sharon, Lassen, Ulrik Niels, Rashal, Tami, Cooksey, Jennifer, Landesman, Yosef, Pond, Gregory, Oza, Amit M., Kauffman, Michael, Siu, Lillian L., Bedard, Philippe L., Mahaseth, Hemchandra, Mirza, Mansoor Raza, Mahipal, Amit

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Abstract A188: SINE resistant fibrosarcoma cells reveal changes in profile of gene expression, but continue to be sensitive to combination treatment by proteasome inhibition von Crochiere, Marsha L., Kashyap, Trinayan, Saint-Martin, Jean-Richard, Shechter, Sharon, Kalid, Ori, Shacham, Eran, Senapedis, William, Klebanov, Boris, Tamir, Sharon, del Alamo, Diego, Hamuza, Mwanasha, Golan, Gali, Baloglu, Erkan, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Landesman, Yosef

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Abstract 1831: Selective inhibitors of nuclear export (SINE) induce multiple tumor suppressor proteins (TSP) activity and show single agent antitumor effect and synergy with Bcl-2... von McCauley, Dilara, Rashal, Tami, Shacham, Sharon, Kauffman, Michael, Landesman, Yossi, St-Martin, Jean, Kashyap, Trinayan, Senapedis, William, Williams, Jennifer L., Nir, Raphael, Illuz, Maya, Peled, Nir

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Abstract 2943: KPT-SINE (Selective Inhibitors of Nuclear Export) induce apoptosis in colon cancer cells in-vitro and in-vivo through nuclear localization of Tumor Suppressor Protei... von Senapedis, William, Landesman, Yossi, St-Martin, Jean, Kashyap, Trinayan, Plamondon, Louis, Sandanayaka, Vincent, Shechter, Sharon, Froim, Doriana, McCauley, Dilara, Nir, Raphael, Williams, Jennifer L., Kauffman, Michael, Shacham, Sharon

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First-in-class, first-in-human phase I trial of KPT-330, a selective inhibitor of nuclear export (SINE) in patients (pts) with advanced solid tumors von Razak, Albiruni R A, Soerensen, Morten Mau, Mahipal, Amit, Shacham, Sharon, Yau, Cindy Y. F., Lassen, Ulrik Niels, McCauley, Dilara, Cooksey, Jennifer, Tan, David Shao Peng, Saint-Martin, Jean-Richard, Landesman, Yossi, Pond, Gregory, Oza, Amit M., Kauffman, Michael, Siu, Lillian L., Mirza, Mansoor Raza

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CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis von Tai, Yu-Tzu, Landesman, Yosef, Acharya, Chirag, Zhong, Mike Y, Calle, Yolanda, Cea, Michele, Hu, Yiguo, Cagnetta, Antonia, Tannenbaum, Daniel, Chen, Michelle, Munshi, Aditya, Senapedis, William, Saint-Martin, Jean-Richard, Kashyap, Trinayan, Ying, Haoqiang, McCauley, Dilara, Shacham, Sharon, Kauffman, Michael, Gu, Yumei, Wu, Lizi, Schey, Stephen, Kung, Andrew L., Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C.

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