Rasgos estructurales de la integración en una Europa ampliada: convergencia económica y especialización industrial von Landesman, Michael A

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ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly von Ku, Pei-I, Bendjennat, Mourad, Ballew, Jeff, Landesman, Michael B, Saffarian, Saveez

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Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding von Zhai, Qianting, Landesman, Michael B, Robinson, Howard, Sundquist, Wesley I, Hill, Christopher P

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XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer von Cheng, Yan, Holloway, Michael P, Nguyen, Kevin, McCauley, Dilara, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Altura, Rachel A

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Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias von Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo

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Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma von Aboukameel, Amro, Muqbil, Irfana, Senapedis, William, Baloglu, Erkan, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Philip, Philip A, Mohammad, Ramzi M, Azmi, Asfar S

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Identification and Structural Characterization of the ALIX-Binding Late Domains of Simian Immunodeficiency Virus SIVmac239 and SIVagmTan-1 von Zhai, Qianting, Landesman, Michael B, Robinson, Howard, Sundquist, Wesley I, Hill, Christopher P

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Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer von Chen, Ying, Camacho, Sandra Catalina, Silvers, Thomas R, Razak, Albiruni R A, Gabrail, Nashat Y, Gerecitano, John F, Kalir, Eva, Pereira, Elena, Evans, Brad R, Ramus, Susan J, Huang, Fei, Priedigkeit, Nolan, Rodriguez, Estefania, Donovan, Michael, Khan, Faisal, Kalir, Tamara, Sebra, Robert, Uzilov, Andrew, Chen, Rong, Sinha, Rileen, Halpert, Richard, Billaud, Jean-Noel, Shacham, Sharon, McCauley, Dilara, Landesman, Yosef, Rashal, Tami, Kauffman, Michael, Mirza, Mansoor R, Mau-Sørensen, Morten, Dottino, Peter, Martignetti, John A

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Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma von Chari, Ajai, Vogl, Dan T, Gavriatopoulou, Maria, Nooka, Ajay K, Yee, Andrew J, Huff, Carol A, Moreau, Philippe, Dingli, David, Cole, Craig, Lonial, Sagar, Dimopoulos, Meletios, Stewart, A. Keith, Richter, Joshua, Vij, Ravi, Tuchman, Sascha, Raab, Marc S, Weisel, Katja C, Delforge, Michel, Cornell, Robert F, Kaminetzky, David, Hoffman, James E, Costa, Luciano J, Parker, Terri L, Levy, Moshe, Schreder, Martin, Meuleman, Nathalie, Frenzel, Laurent, Mohty, Mohamad, Choquet, Sylvain, Schiller, Gary, Comenzo, Raymond L, Engelhardt, Monika, Illmer, Thomas, Vlummens, Philip, Doyen, Chantal, Facon, Thierry, Karlin, Lionel, Perrot, Aurore, Podar, Klaus, Kauffman, Michael G, Shacham, Sharon, Li, Lingling, Tang, Shijie, Picklesimer, Carla, Saint-Martin, Jean-Richard, Crochiere, Marsha, Chang, Hua, Parekh, Samir, Landesman, Yosef, Shah, Jatin, Richardson, Paul G, Jagannath, Sundar

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Activation of the Retroviral Budding Factor ALIX von QIANTING ZHAI, LANDESMAN, Michael B, CHUNG, Hyo-Young, DIERKERS, Adam, JEFFRIES, Cy M, TREWHELLA, Jill, HILL, Christopher P, SUNDQUIST, Wesley I

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XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer von Kim, Jimi, McMillan, Elizabeth, Kim, Hyun Seok, Venkateswaran, Niranjan, Makkar, Gurbani, Rodriguez-Canales, Jaime, Villalobos, Pamela, Neggers, Jasper Edgar, Mendiratta, Saurabh, Wei, Shuguang, Landesman, Yosef, Senapedis, William, Baloglu, Erkan, Chow, Chi-Wan B., Frink, Robin E., Gao, Boning, Roth, Michael, Minna, John D., Daelemans, Dirk, Wistuba, Ignacio I., Posner, Bruce A., Scaglioni, Pier Paolo, White, Michael A.

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Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo von Kashyap, Trinayan, Murray, Jackelyn, Walker, Christopher J., Chang, Hua, Tamir, Sharon, Hou, Bing, Shacham, Sharon, Kauffman, Michael G., Tripp, Ralph A., Landesman, Yosef

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First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors von Abdul Razak, Albiruni R, Mau-Soerensen, Morten, Gabrail, Nashat Y, Gerecitano, John F, Shields, Anthony F, Unger, Thaddeus J, Saint-Martin, Jean R, Carlson, Robert, Landesman, Yosef, McCauley, Dilara, Rashal, Tami, Lassen, Ulrik, Kim, Richard, Stayner, Lee-Anne, Mirza, Mansoor R, Kauffman, Michael, Shacham, Sharon, Mahipal, Amit

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Selinexor in patients with relapsed or refractory diffuse large B-cell lymphoma (SADAL): a single-arm, multinational, multicentre, open-label, phase 2 trial von Kalakonda, Nagesh, Maerevoet, Marie, Cavallo, Federica, Follows, George, Goy, Andre, Vermaat, Joost S P, Casasnovas, Olivier, Hamad, Nada, Zijlstra, Josée M, Bakhshi, Sameer, Bouabdallah, Reda, Choquet, Sylvain, Gurion, Ronit, Hill, Brian, Jaeger, Ulrich, Sancho, Juan Manuel, Schuster, Michael, Thieblemont, Catherine, De la Cruz, Fátima, Egyed, Miklos, Mishra, Sourav, Offner, Fritz, Vassilakopoulos, Theodoros P, Warzocha, Krzysztof, McCarthy, Daniel, Ma, Xiwen, Corona, Kelly, Saint-Martin, Jean-Richard, Chang, Hua, Landesman, Yosef, Joshi, Anita, Wang, Hongwei, Shah, Jatin, Shacham, Sharon, Kauffman, Michael, Van Den Neste, Eric, Canales, Miguel A

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XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa) von Gravina, Giovanni Luca, Tortoreto, Monica, Mancini, Andrea, Addis, Alessandro, Di Cesare, Ernesto, Lenzi, Andrea, Landesman, Yosef, McCauley, Dilara, Kauffman, Michael, Shacham, Sharon, Zaffaroni, Nadia, Festuccia, Claudio

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XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus von Ranganathan, Parvathi, Kashyap, Trinayan, Yu, Xueyan, Meng, Xiaomei, Lai, Tzung-Huei, McNeil, Betina, Bhatnagar, Bhavana, Shacham, Sharon, Kauffman, Michael, Dorrance, Adrienne M, Blum, William, Sampath, Deepa, Landesman, Yosef, Garzon, Ramiro

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Clinical Dosing Regimen of Selinexor Maintains Normal Immune Homeostasis and T-cell Effector Function in Mice: Implications for Combination with Immunotherapy von Tyler, Paul M, Servos, Mariah M, de Vries, Romy C, Klebanov, Boris, Kashyap, Trinayan, Sacham, Sharon, Landesman, Yosef, Dougan, Michael, Dougan, Stephanie K

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Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms von Walker, Christopher J., Chang, Hua, Henegar, Leah, Kashyap, Trinayan, Shacham, Sharon, Sommer, Josh, Wick, Michael J., Levy, Joan, Landesman, Yosef

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DEK-NUP214 Acute Myeloid Leukemia Depends on CRM1 In Vivo von Charles Cano, Fiorella, Kloos, Arnold, Hebalkar, Rucha Yeshwanta, Gabdoulline, Razif, Fangmann, Thomas, Landesman, Yosef, Döhner, Konstanze, Shcherbata, Halyna R., Ganser, Arnold, Heuser, Michael

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A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma von Lassman, Andrew B, Wen, Patrick Y, van den Bent, Martin J, Plotkin, Scott R, Walenkamp, Annemiek M E, Green, Adam L, Li, Kai, Walker, Christopher J, Chang, Hua, Tamir, Sharon, Henegar, Leah, Shen, Yao, Alvarez, Mariano J, Califano, Andrea, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Mau-Sørensen, Morten

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