Insulinoma-Associated-1: From Neuroendocrine Tumor Marker to Cancer Therapeutics von Chen, Chiachen, Notkins, Abner L, Lan, Michael S

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Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathway... von CHEN, CHIACHEN, CHANG, YUAN-CHING, LAN, MICHAEL S, BRESLIN, MARY

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Small Molecules Targeting INSM1 for the Treatment of High-Risk Neuroblastoma von Lan, Michael S, Chen, Chiachen

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Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation von Lan, Michael S, Breslin, Mary B

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Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma von Chen, Chiachen, Lan, Michael S.

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INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma von Chen, Chiachen, Breslin, Mary B, Lan, Michael S

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Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells von Nelson, Branden R., Hartman, Byron H., Georgi, Sean A., Lan, Michael S., Reh, Thomas A.

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Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction von Zhang, Tao, Chen, Chiachen, Breslin, Mary B., Song, Kejing, Lan, Michael S.

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Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance von Wang, Lin, Sun, Zhong Sheng, Xiang, Bingwu, Wei, Chi-Ju, Wang, Yan, Sun, Kevin, Chen, Guanjie, Lan, Michael S, Carmona, Gilberto N, Notkins, Abner L, Cai, Tao

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A promoter-driven assay for INSM1-associated signaling pathway in neuroblastoma von Chen, Chiachen, Lan, Michael S.

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Ectopic expression of a small cell lung cancer transcription factor, INSM1 impairs alveologenesis in lung development von Chen, Chiachen, Breslin, Mary B, Lan, Michael S

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Repurposing a plant alkaloid homoharringtonine targets insulinoma associated-1 in N-Myc-activated neuroblastoma von Chen, Chiachen, Wu, Jiande, Hicks, Chindo, Lan, Michael S.

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Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest von Zhang, Tao, Liu, Wei-Dong, Saunee, Nicolle A., Breslin, Mary B., Lan, Michael S.

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Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer von Chen, Chiachen, Breslin, Mary B., Lan, Michael S.

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Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology von Conn, Kelly J., Gao, Wenwu, McKee, Ann, Lan, Michael S., Ullman, M. David, Eisenhauer, Patricia B., Fine, Richard E., Wells, John M.

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Human CD1D gene expression is regulated by LEF-1 through distal promoter regulatory elements von Chen, Qiao-Yi, Zhang, Tao, Pincus, Seth H, Wu, Shixiu, Ricks, David, Liu, Donald, Sun, Zhongsheng, Maclaren, Noel, Lan, Michael S

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INSM1 functions as a transcriptional repressor of the neuroD/β2 gene through the recruitment of cyclin D1 and histone deacetylases von Liu, Wei-Dong, Wang, Hong-Wei, Muguira, Michelle, Breslin, Mary B., Lan, Michael S.

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NeuroD1/E47 Regulates the E-box Element of a Novel Zinc Finger Transcription Factor, IA-1, in Developing Nervous System von Breslin, Mary B., Zhu, Min, Lan, Michael S.

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5′-Iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth von Chen, Chiachen, Breslin, Mary Beth, Guidry, Jessie J., Lan, Michael S.

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Targeted Disruption of the Protein Tyrosine Phosphatase-Like Molecule IA-2 Results in Alterations in Glucose Tolerance Tests and Insulin Secretion von SAEKI, Keiichi, ZHU, Min, KUBOSAKI, Atsutaka, XIE, Jingping, LAN, Michael S, NOTKINS, Abner Louis

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