Compact Cas9d and HEARO enzymes for genome editing discovered from uncultivated microbes von Aliaga Goltsman, Daniela S., Alexander, Lisa M., Lin, Jyun-Liang, Fregoso Ocampo, Rodrigo, Freeman, Benjamin, Lamothe, Rebecca C., Perez Rivas, Andres, Temoche-Diaz, Morayma M., Chadha, Shailaja, Nordenfelt, Natalie, Janson, Owen P., Barr, Ian, Devoto, Audra E., Cost, Gregory J., Butterfield, Cristina N., Thomas, Brian C., Brown, Christopher T.

Volltext

1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells von Narayan, Santosh, Drain, Allison P, Swanson, Nathaniel, Rouillard, Nicholas, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

Volltext

355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses von Drain, Allison P, Rouillard, Nicholas, Swanson, Nathaniel, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

Volltext

Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome Engineering for Cell Therapy Development von Cost, Gregory J., Lamothe, Rebecca C., Storlie, Meghan D., Rivas, Andres, Espinosa, Diego A., Goltsman, Daniela S.A., Alexander, Lisa, Butterfield, Cristina N., Brown, Christopher T., Thomas, Brian C.

Volltext

Cancer Vulnerabilities Unveiled by Genomic Loss von Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Bhatia, Sangeeta N., Beroukhim, Rameen, Hahn, William C.

Volltext

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability von Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen

Volltext

Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses von Elde, Nels C., Child, Stephanie J., Eickbush, Michael T., Kitzman, Jacob O., Rogers, Kelsey S., Shendure, Jay, Geballe, Adam P., Malik, Harmit S.

Volltext

Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection A Multicenter Cross-Sectional Analysis von Bjornstad, Erica C., Krallman, Kelli A., Askenazi, David, Zappitelli, Michael, Goldstein, Stuart L., Basu, Rajit K.

Volltext

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations von Kurata, Harley T., Jamra, Rami Abou, Alkelai, Anna, Antonarakis, Stylianos E., Bolkier, Yoav, Dickson, Patricia, Donald, Kirsten A., Eliyahu, Aviva, Emrick, Lisa, Odent, Sylvie, Ortiz-Gonzalez, Xilma, Rosenfeld, Jill A., Skraban, Cara, Alejandro, Mercedes E., Azamian, Mahshid S., Chao, Hsiao-Tuan, Dai, Hongzheng, Dhar, Shweta U., Karaviti, Lefkothea, Lee, Brendan H., Rosenfeld, Jill A., Scott, Daryl A., Wangler, Michael F., Eng, Christine M., Sullivan, Kathleen, Goldstein, David B., McConkie-Rosell, Allyn, Schoch, Kelly, Shashi, Vandana, Beggs, Alan H., Cobban, Laurel A., Cooper, Cynthia M., Fieg, Elizabeth L., Korrick, Susan, Loscalzo, Joseph, Maas, Richard L., MacRae, Calum A., Stoler, Joan M., Nagy, Anna, Dasari, Surendra, Lanpher, Brendan C., Bivona, Stephanie, Isasi, Rosario, Levitt, Roy, Tekin, Mustafa, Thorson, Willa, Eckstein, David J., Mamounas, Laura A., D’Souza, Precilla, Ferreira, Carlos, Godfrey, Rena A., Groden, Catherine A., Macnamara, Ellen F., Maduro, Valerie V., Nath, Avi, Baker, Eva, Power, Bradley, Mosbrook-Davis, Deborah, Rossignol, Francis, Yousef, Muhammad, Amendola, Laura, Bamshad, Michael, Beck, Anita, Bennett, Jimmy, Blue, Elizabeth, Chanprasert, Sirisak, Glass, Ian, Jarvik, Gail P., Jarvik, Jeffrey, Mefford, Heather, Merritt, J. Lawrence, Raskind, Wendy, Sybert, Virginia, Wener, Mark, Wenger, Tara, Fisher, Paul G., Reuter, Chloe M., Smith, Kevin S., Zastrow, Diane B., Nakano-Okuno, Mariko, Whitlock, Jordan, Butte, Manish J., Fogel, Brent L., Krakow, Deborah, Lee, Hane, Palmer, Christina G.S., Papp, Jeanette C., Woods, Jeremy D., Andrews, Ashley, Pace, Laura, Viskochil, Dave, Bican, Anna, Kennedy, Jennifer, Cogan, Joy D., Cole, F. Sessions, Kiley, Dana, Sisco, Kathy, Schedl, Timothy, Solnica-Krezel, Lilianna, Pitt, Geoffrey S.

Volltext

Anti-IL4Ra therapy is superior to other biologic classes in treating allergic bronchopulmonary aspergillosis von Lamothe, Pedro A., Humphrey Pruett, Charles Lewis, Smirnova, Natalia, Shepherd, Aaron, Runnstrom, Martin C., Park, Jiwon, Zhang, Rebecca H., Zhao, Leshan, Swenson, Colin, Lee, F. Eun-Hyung

Volltext

Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations (Jun, 10.1038/s41436-021-01232-8, 2021) von Rodan, Lance H., Spillmann, Rebecca C., Kurata, Harley T., Lamothe, Shawn M., Maghera, Jasmine, Jamra, Rami Abou, Alkelai, Anna, Antonarakis, Stylianos E., Atallah, Isis, Bar-Yosef, Omer, Bilan, Frederic, Bjorgo, Kathrine, Blanc, Xavier, Van Bogaert, Patrick, Bolkier, Yoav, Burrage, Lindsay C., Christ, Bjorn U., Granadillo, Jorge L., Dickson, Patricia, Donald, Kirsten A., Dubourg, Christele, Eliyahu, Aviva, Emrick, Lisa, Engleman, Kendra, Gonfiantini, Michaela Veronika, Good, Jean-Marc, Kalser, Judith, Kloeckner, Chiara, Lachmeijer, Guus, Macchiaiolo, Marina, Nicita, Francesco, Odent, Sylvie, O'Heir, Emily, Ortiz-Gonzalez, Xilma, Pacio-Miguez, Marta, Palomares-Bralo, Maria, Pena, Loren, Platzer, Konrad, Quinodoz, Mathieu, Ranza, Emmanuelle, Rosenfeld, Jill A., Roulet-Perez, Eliane, Santani, Avni, Santos-Simarro, Fernando, Pode-Shakked, Ben, Skraban, Cara, Slaugh, Rachel, Superti-Furga, Andrea, Thiffault, Isabelle, van Jaabrsveld, Richard H., Vincent, Marie, Wang, Hong-Gang, Zacher, Pia, Rush, Eric, Pitt, Geoffrey S., Au, Ping Yee Billie, Shashi, Vandana

Volltext

Abstract 4369: Genome-wide copy number dependency analysis identifies partial copy loss of SF3B1 as a novel cancer vulnerability von Paolella, Brenton R., Gibson, William J., Urbanski, Laura M., Alberta, John A., Zack, Travis I., Bandopadhayay, Pratiti, Nichols, Caitlin A., Agarwalla, Pankaj K., Brown, Meredith S., Lamothe, Rebecca, Yu, Yong, Choi, Peter S., Obeng, Esther A., Heckl, Dirk, Ebert, Benjamin L., Wei, Guo, Wang, Belinda, Hahn, William C., Vazquez, Francisca, Weir, Barbara A., Stiles, Charles D., Reed, Robin, Beroukhim, Rameen

Volltext

ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

Volltext bestellen

ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

Volltext bestellen

ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

Volltext bestellen

NOVEL ENGINEERED AND CHIMERIC NUCLEASES von LIN, Jyun-Liang, TEMOCHE-DIAZ, Morayma M, BUTTERFIELD, Cristina, BROOKS, Alan, LAMOTHE, Rebecca, THOMAS, Brian C, BROWN, Christopher, COST, Greg

Volltext bestellen

ENDONUCLEASE SYSTEMS von BUTTERFIELD, Cristina, GOLTSMAN, Daniela S.A, LAMOTHE, Rebecca, DEVOTO, Audra, THOMAS, Brian C, BROWN, Christopher, ALEXANDER, Lisa

Volltext bestellen

ENDONUCLEASE SYSTEMS von DEVOTO, AUDRA, GOLTSMAN, DANIELA S.A, THOMAS, BRIAN C, BUTTERFIELD, CRISTINA, ALEXANDER, LISA, BROWN, CHRISTOPHER, LAMOTHE, REBECCA

Volltext bestellen

ENGINEERED AND CHIMERIC NUCLEASES von LIN, Jyun-Liang, TEMOCHE-DIAZ, Morayma M, BUTTERFIELD, Cristina, BROOKS, Alan, LAMOTHE, Rebecca, THOMAS, Brian C, BROWN, Christopher, COST, Greg

Volltext bestellen

NOVEL ENGINEERED AND CHIMERIC NUCLEASES von LIN, Jyun-Liang, TEMOCHE-DIAZ, Morayma M, BUTTERFIELD, Cristina, BROOKS, Alan, LAMOTHE, Rebecca, THOMAS, Brian C, BROWN, Christopher, COST, Greg

Volltext bestellen