Systematic discovery of complex insertions and deletions in human cancers von Ye, Kai, Wang, Jiayin, Jayasinghe, Reyka, Lameijer, Eric-Wubbo, McMichael, Joshua F, Ning, Jie, McLellan, Michael D, Xie, Mingchao, Cao, Song, Yellapantula, Venkata, Huang, Kuan-lin, Scott, Adam, Foltz, Steven, Niu, Beifang, Johnson, Kimberly J, Moed, Matthijs, Slagboom, P Eline, Chen, Feng, Wendl, Michael C, Ding, Li

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Characteristics of de novo structural changes in the human genome von Kloosterman, Wigard P, Francioli, Laurent C, Hormozdiari, Fereydoun, Marschall, Tobias, Hehir-Kwa, Jayne Y, Abdellaoui, Abdel, Lameijer, Eric-Wubbo, Moed, Matthijs H, Koval, Vyacheslav, Renkens, Ivo, van Roosmalen, Markus J, Arp, Pascal, Karssen, Lennart C, Coe, Bradley P, Handsaker, Robert E, Suchiman, Eka D, Cuppen, Edwin, Thung, Djie Tjwan, McVey, Mitch, Wendl, Michael C, Uitterlinden, André, van Duijn, Cornelia M, Swertz, Morris A, Wijmenga, Cisca, van Ommen, GertJan B, Slagboom, P Eline, Boomsma, Dorret I, Schönhuth, Alexander, Eichler, Evan E, de Bakker, Paul I W, Ye, Kai, Guryev, Victor

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A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis von Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Kloppenburg, Margreet, Ye, Kai, Lameijer, Eric-Wubbo E M W, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid

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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array von Slieker, Roderick C, Bos, Steffan D, Goeman, Jelle J, Bovée, Judith Vmg, Talens, Rudolf P, van der Breggen, Ruud, Suchiman, H Eka D, Lameijer, Eric-Wubbo, Putter, Hein, van den Akker, Erik B, Zhang, Yanju, Jukema, J Wouter, Slagboom, P Eline, Meulenbelt, Ingrid, Heijmans, Bastiaan T

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Computational pan-genomics: status, promises and challenges von Marschall, Tobias, Marz, Manja, Abeel, Thomas, Dijkstra, Louis, Dutilh, Bas E, Ghaffaari, Ali, Kersey, Paul, Kloosterman, Wigard P, Mäkinen, Veli, Novak, Adam M, Paten, Benedict, Porubsky, David, Rivals, Eric, Alkan, Can, Baaijens, Jasmijn A, Paul I W De Bakker, Boeva, Valentina, Bonnal, Raoul J P, Chiaromonte, Francesca, Chikhi, Rayan, Ciccarelli, Francesca D, Cijvat, Robin, Datema, Erwin, Van Duijn, Cornelia M, Eichler, Evan E, Ernst, Corinna, Eskin, Eleazar, Garrison, Erik, El-Kebir, Mohammed, Klau, Gunnar W, Korbel, Jan O, Eric-Wubbo Lameijer, Langmead, Benjamin, Martin, Marcel, Medvedev, Paul, Mu, John C, Neerincx, Pieter, Ouwens, Klaasjan, Peterlongo, Pierre, Pisanti, Nadia, Rahmann, Sven, Raphael, Ben, Reinert, Knut, de Ridder, Dick, de Ridder, Jeroen, Schlesner, Matthias, Schulz-Trieglaff, Ole, Sanders, Ashley D, Sheikhizadeh, Siavash, Shneider, Carl, Smit, Sandra, Valenzuela, Daniel, Wang, Jiayin, Wessels, Lodewyk, Zhang, Ying, Guryev, Victor, Vandin, Fabio, Ye, Kai, Schönhuth, Alexander

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A high-quality human reference panel reveals the complexity and distribution of genomic structural variants von Hehir-Kwa, Jayne Y., Marschall, Tobias, Kloosterman, Wigard P., Francioli, Laurent C., Baaijens, Jasmijn A., Dijkstra, Louis J., Abdellaoui, Abdel, Koval, Vyacheslav, Thung, Djie Tjwan, Wardenaar, René, Renkens, Ivo, Coe, Bradley P., Deelen, Patrick, de Ligt, Joep, Lameijer, Eric-Wubbo, van Dijk, Freerk, Hormozdiari, Fereydoun, Uitterlinden, André G., van Duijn, Cornelia M., Eichler, Evan E., de Bakker, Paul I. W., Swertz, Morris A., Wijmenga, Cisca, van Ommen, Gert-Jan B., Slagboom, P. Eline, Boomsma, Dorret I., Schönhuth, Alexander, Ye, Kai, Guryev, Victor

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An integrated map of structural variation in 2,504 human genomes von Sudmant, Peter H., Rausch, Tobias, Gardner, Eugene J., Handsaker, Robert E., Abyzov, Alexej, Huddleston, John, Zhang, Yan, Ye, Kai, Jun, Goo, Hsi-Yang Fritz, Markus, Konkel, Miriam K., Malhotra, Ankit, Stütz, Adrian M., Shi, Xinghua, Paolo Casale, Francesco, Chen, Jieming, Hormozdiari, Fereydoun, Dayama, Gargi, Chen, Ken, Malig, Maika, Chaisson, Mark J. P., Walter, Klaudia, Meiers, Sascha, Kashin, Seva, Garrison, Erik, Auton, Adam, Lam, Hugo Y. K., Jasmine Mu, Xinmeng, Alkan, Can, Antaki, Danny, Bae, Taejeong, Cerveira, Eliza, Chines, Peter, Chong, Zechen, Clarke, Laura, Dal, Elif, Ding, Li, Emery, Sarah, Fan, Xian, Gujral, Madhusudan, Kahveci, Fatma, Kidd, Jeffrey M., Kong, Yu, Lameijer, Eric-Wubbo, McCarthy, Shane, Flicek, Paul, Gibbs, Richard A., Marth, Gabor, Mason, Christopher E., Menelaou, Androniki, Muzny, Donna M., Nelson, Bradley J., Noor, Amina, Parrish, Nicholas F., Pendleton, Matthew, Quitadamo, Andrew, Raeder, Benjamin, Schadt, Eric E., Romanovitch, Mallory, Schlattl, Andreas, Sebra, Robert, Shabalin, Andrey A., Untergasser, Andreas, Walker, Jerilyn A., Wang, Min, Yu, Fuli, Zhang, Chengsheng, Zhang, Jing, Zheng-Bradley, Xiangqun, Zhou, Wanding, Zichner, Thomas, Sebat, Jonathan, Batzer, Mark A., McCarroll, Steven A., Mills, Ryan E., Gerstein, Mark B., Bashir, Ali, Stegle, Oliver, Devine, Scott E., Lee, Charles, Eichler, Evan E., Korbel, Jan O.

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The Molecule Evoluator. An Interactive Evolutionary Algorithm for the Design of Drug-Like Molecules von Lameijer, Eric-Wubbo, Kok, Joost N, Bäck, Thomas, IJzerman, Ad P

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A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors von Ye, Kai, Lameijer, Eric-Wubbo M., Beukers, Margot W., IJzerman, Adriaan P.

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Precision Medicine: What Challenges Are We Facing? von Xue, Yu, Lameijer, Eric-Wubbo, Ye, Kai, Zhang, Kunlin, Chang, Suhua, Wang, Xiaoyue, Wu, Jianmin, Gao, Ge, Zhao, Fangqing, Li, Jian, Han, Chunsheng, Xu, Shuhua, Xiao, Jingfa, Yang, Xuerui, Ying, Xiaomin, Zhang, Xuegong, Chen, Wei-Hua, Liu, Yun, Zhang, Zhang, Huang, Kun, Yu, Jun

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Mining a Chemical Database for Fragment Co-occurrence:  Discovery of “Chemical Clichés” von Lameijer, Eric-Wubbo, Kok, Joost N, Bäck, Thomas, IJzerman, Ad P

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Integrated clinical and omics approach to rare diseases: novel genes and oligogenic inheritance in holoprosencephaly von Kim, Artem, Savary, Clara, Dubourg, Christèle, Carré, Wilfrid, Mouden, Charlotte, Hamdi-Rozé, Houda, Guyodo, Hélène, Douce, Jerome Le, Pasquier, Laurent, Flori, Elisabeth, Gonzales, Marie, Bénéteau, Claire, Boute, Odile, Attié-Bitach, Tania, Roume, Joelle, Goujon, Louise, Akloul, Linda, Odent, Sylvie, Watrin, Erwan, Dupé, Valérie, de Tayrac, Marie, David, Véronique

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Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs von Ye, Kai, Beekman, Marian, Lameijer, Eric-Wubbo, Zhang, Yanju, Moed, Matthijs H., van den Akker, Erik B., Deelen, Joris, Houwing-Duistermaat, Jeanine J., Kremer, Dennis, Anvar, Seyed Yahya, Laros, Jeroen F. J., Jones, David, Raine, Keiran, Blackburne, Ben, Potluri, Shobha, Long, Quan, Guryev, Victor, van der Breggen, Ruud, Westendorp, Rudi G. J., ‘t Hoen, Peter A. C., den Dunnen, Johan, van Ommen, Gert Jan B., Willemsen, Gonneke, Pitts, Steven J., Cox, David R., Ning, Zemin, Boomsma, Dorret I., Slagboom, P. Eline

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PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data von Zhang, Yanju, Lameijer, Eric-Wubbo, 't Hoen, Peter A. C., Ning, Zemin, Slagboom, P. Eline, Ye, Kai

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Negative selection in humans and fruit flies involves synergistic epistasis von Sohail, Mashaal, Vakhrusheva, Olga A., Sul, Jae Hoon, Pulit, Sara L., Francioli, Laurent C., van den Berg, Leonard H., Veldink, Jan H., de Bakker, Paul I. W., Bazykin, Georgii A., Kondrashov, Alexey S., Sunyaev, Shamil R.

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Designing Active Template Molecules by Combining Computational De Novo Design and Human Chemist's Expertise von Lameijer, Eric-Wubbo, Tromp, Reynier A, Spanjersberg, Ronald F, Brussee, Johannes, IJzerman, Adriaan P

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Whole-genome sequence variation, population structure and demographic history of the Dutch population von Francioli, Laurent C, Menelaou, Androniki, Pulit, Sara L, van Dijk, Feerk, Palamara, Pier Francesco, Elbers, Clara C, Neerincx, Pieter B T, Ye, Kai, Guryev, Victor, Kloosterman, Wigard P, Deelen, Patrick, Abdellaoui, Abdel, van Leeuwen, Elisabeth M, van Oven, Mannis, Vermaat, Martijn, Li, Mingkun, Laros, Jeroen F J, Karssen, Lennart C, Kanterakis, Alexandros, Amin, Najaf, Hottenga, Jouke Jan, Lameijer, Eric-Wubbo, Kattenberg, Mathijs, Dijkstra, Martijn, Byelas, Heorhiy, van Setten, Jessica, van Schaik, Barbera D C, Bot, Jan, Nijman, Isaäc J, Renkens, Ivo, Marschall, Tobias, Schönhuth, Alexander, Hehir-Kwa, Jayne Y, Handsaker, Robert E, Polak, Paz, Sohail, Mashaal, Vuzman, Dana, Hormozdiari, Fereydoun, van Enckevort, David, Mei, Hailiang, Koval, Vyacheslav, Moed, Matthijs H, van der Velde, K Joeri, Rivadeneira, Fernando, Estrada, Karol, Medina-Gomez, Carolina, Isaacs, Aaron, McCarroll, Steven A, Beekman, Marian, de Craen, Anton J M, Suchiman, H Eka D, Hofman, Albert, Oostra, Ben, Uitterlinden, André G, Willemsen, Gonneke, Platteel, Mathieu, Veldink, Jan H, van den Berg, Leonard H, Pitts, Steven J, Potluri, Shobha, Sundar, Purnima, Cox, David R, Sunyaev, Shamil R, den Dunnen, Johan T, Stoneking, Mark, de Knijff, Peter, Kayser, Manfred, Li, Qibin, Li, Yingrui, Du, Yuanping, Chen, Ruoyan, Cao, Hongzhi, Li, Ning, Cao, Sujie, Wang, Jun, Bovenberg, Jasper A, Pe'er, Itsik, Slagboom, P Eline, van Duijn, Cornelia M, Boomsma, Dorret I, van Ommen, Gert-Jan B, de Bakker, Paul I W, Swertz, Morris A, Wijmenga, Cisca

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Evolutionary Algorithms in Drug Design von Lameijer, Eric-Wubbo, Bäck, Thomas, Kok, Joost N., Ijzerman, AD P.

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Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck von Li, Mingkun, Rothwell, Rebecca, Vermaat, Martijn, Wachsmuth, Manja, Schröder, Roland, Laros, Jeroen F J, van Oven, Mannis, de Bakker, Paul I W, Bovenberg, Jasper A, van Duijn, Cornelia M, van Ommen, Gert-Jan B, Slagboom, P Eline, Swertz, Morris A, Wijmenga, Cisca, Kayser, Manfred, Boomsma, Dorret I, Zöllner, Sebastian, de Knijff, Peter, Stoneking, Mark

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Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency von Kiezun, Adam, Pulit, Sara L, Francioli, Laurent C, van Dijk, Freerk, Swertz, Morris, Boomsma, Dorret I, van Duijn, Cornelia M, Slagboom, P Eline, van Ommen, G J B, Wijmenga, Cisca, de Bakker, Paul I W, Sunyaev, Shamil R

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