KS05.6.A T-CELL THERAPY COMBINED WITH LOW-INTENSITY PULSED FOCUSED ULTRASOUND, MICROBUBBLES AND POLY-ICLC PROMOTES THE PRESENTATION OF BRAIN-DERIVED ANTIGENS, BREAKING CNS TOLERANC... von Gallus, M, Yamamichi, A, Andres Arrieta, V, Saijo, A, Chuntova, P, Haegelin, J, Phyu, S, Phung, L, Long, J, Lakshmanachetty, S, Nejo, T, Okada, K, Chen, L, Habashy, K, Gould, A, Amidei, C, Chang, C, Stupp, R, Canney, M, Sonabend, A, Okada, H

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Mapping the tumor-infiltrating immune cells during glioblastoma progression von Lakshmanachetty, Senthilnath, Mitra, Siddhartha S.

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Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma von Gallus, Marco, Kwok, Darwin, Lakshmanachetty, Senthilnath, Yamamichi, Akane, Okada, Hideho

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Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. Cancers 2023, 15 , 3726 von Gallus, Marco, Kwok, Darwin, Lakshmanachetty, Senthilnath, Yamamichi, Akane, Okada, Hideho

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Correction: Gallus et al. Immunotherapy Approaches in Isocitrate-Dehydrogenase-Mutant Low-Grade Glioma. ICancers/I 2023, I15/I, 3726 von Gallus, Marco, Kwok, Darwin, Lakshmanachetty, Senthilnath, Yamamichi, Akane, Okada, Hideho

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IMMU-52. LOW-INTENSITY PULSED ULTRASOUND CONDUCTS ANTIGEN-INDEPENDENT T CELL HOMING INTO THE BRAIN PARENCHYMA WITH THE INTACT BLOOD-BRAIN BARRIER von Gallus, Marco, Saijo, Atsuro, Haegelin, Jeffrey, Chuntova, Pavlina, Yamamichi, Akane, Lakshmanachetty, Senthilnath, Okada, Hideho

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XRT-02. SINGLE-CELL RNA SEQUENCING IDENTIFIES FUNCTIONAL MACROPHAGE SUBSETS THAT ARE ENRICHED IN RESPONSE TO DIFFERENTIAL PHAGOCYTOSIS INDUCTION AGAINST GLIOMA von Lakshmanachetty, Senthilnath, Riemondy, Kent, Donson, Andrew, Balakrishnan, Illango, Venkataraman, Sujatha, Vibhakar, Rajeev, Foreman, Nicholas, Mitra, Siddhartha

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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma von Nejo, Takahide, Wang, Lin, Leung, Kevin K., Wang, Albert, Lakshmanachetty, Senthilnath, Gallus, Marco, Kwok, Darwin W., Hong, Chibo, Chen, Lee H., Carrera, Diego A., Zhang, Michael Y., Stevers, Nicholas O., Maldonado, Gabriella C., Yamamichi, Akane, Watchmaker, Payal B., Naik, Akul, Shai, Anny, Phillips, Joanna J., Chang, Susan M., Wiita, Arun P., Wells, James A., Costello, Joseph F., Diaz, Aaron A., Okada, Hideho

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New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistanc... von Lakshmanachetty, Senthilnath, Cruz-Cruz, Joselyn, Hoffmeyer, Eric, Cole, Allison P, Mitra, Siddhartha S

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Loss of TP63 Promotes the Metastasis of Head and Neck Squamous Cell Carcinoma by Activating MAPK and STAT3 Signaling von Lakshmanachetty, Senthilnath, Balaiya, Velmurugan, High, Whitney A, Koster, Maranke I

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TRP63/TP63 loss accelerates skin tumorigenesis through activation of Wnt/β-catenin signaling von Lakshmanachetty, Senthilnath, Balaiya, Velmurugan, Johnson, Linda K., Koster, Maranke I.

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CNSC-06. REDIRECTING IMMUNOSUPPRESSIVE GLIOMA MICROENVIRONMENT THROUGH PHARMACOLOGICAL INTERVENTION TARGETING NEURONAL ACTIVITY von Nejo, Takahide, Krishna, Saritha, Yamamichi, Akane, Jimenez, Christian, Lakshmanachetty, Senthilnath, Young, Jacob, Phyu, Su, Watchmaker, Payal, Hervey-Jumper, Shawn, Okada, Hideho

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DIPG-32. PRECLINICAL TESTING OF THE EFFICACY AND SAFETY OF CRISPR/CAS9 GENE EDITED CAR-T CELL THERAPY FOR DIFFUSE MIDLINE GLIOMA (DMG) von Balakrishnan, Ilango, Leach, Lillie, Pierce, Angela, Lakshmanachetty, Senthilnath, Madhavan, Krishna, Fosmire, Susan, Chatwin, Hannah, Green, Adam, Fry, Terry, Vibhakar, Rajeev, Kohler, Eric M, Venkataraman, Sujatha

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DIPG-15. NOVEL CNS SENSING SYNNOTCH-CAR T CELLS FOR TARGETING DIFFUSE MIDLINE GLIOMA von Lakshmanachetty, Senthilnath, Simic, Milos, Haegelin, Jeffrey, Watchmaker, Payal, Long, Haoyu, Deucker, Jason, Zhu, Robert, Sheperd, Chanelle, Yu, Wei, Ng, Ben, Wang, Yuan, Troyanskaya, Olga, Cardarelli, Lia, Sidhu, Sachdev, Lim, Wendell, Okada, Hideho

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Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth von Madhavan, Krishna, Balakrishnan, Ilango, Lakshmanachetty, Senthilnath, Pierce, Angela, Sanford, Bridget, Fosmire, Susan, Elajaili, Hanan B, Walker, Faye, Wang, Dong, Nozik, Eva S, Mitra, Siddhartha S, Dahl, Nathan A, Vibhakar, Rajeev, Venkataraman, Sujatha

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IMMU-16. PUBLIC TUMOR-WIDE NEOANTIGENS DERIVED FROM CLONAL ABERRANT SPLICING EVENTS DRIVE TUMOR-SPECIFIC T-CELL RESPONSES von Kwok, Darwin, Stevers, Nicholas, Nejo, Takahide, Jung, Jangham, Chen, Lee, Lakshmanachetty, Senthilnath, Etxeberria, Inaki, Gallus, Marco, Yamamichi, Akane, Ramos, Emilio, Hong, Chibo, Colton, Maggie, Chan, Gary, Du, Aidan, Woo, James, Wiita, Arun, Klebanoff, Christopher, Costello, Joseph, Okada, Hideho

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ATRT-23. SIRT2 cooperates with SMARCB1 to induce a differentiation block in ATRT von Alimova, Irina, Wang, Dong, Pierce, Angela, Lakshmanachetty, Senthilnath, Prince, Eric, Danis, Etienne, Serkova, Natalie, Madhavan, Krishna, Balakrishnan, Ilango, Yang, Min, Lin, Henning, Foreman, Nicholas, Venkataraman, Sujatha, Vibhakar, Rajeev

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IMMU-23. Novel gene-edited CAR-T cell therapy against Diffuse Intrinsic Pontine Glioma von Balakrishnan, Ilango, Leach, Lillie, Lakshmanachetty, Senthilnath, Pierce, Angela, Madhavan, Krishna, Chatwin, Hannah, Fosmire, Susan, Meadows, Christina, Green, Adam, Fry, Terry, Vibhakar, Rajeev, Kohler, Eric M, Venkataraman, Sujatha

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956 Glioma-neuronal circuit remodeling induces regional immunosuppression von Nejo, Takahide, Krishna, Saritha, Yamamichi, Akane, Jimenez, Christian, Young, Jacob S, Lakshmanachetty, Senthilnath, Chen, Tiffany, Phyu, Su, Watchmaker, Payal, Choudhury, Abrar, Raleigh, David R, Hervey-Jumper, Shawn L, Okada, Hideho

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277 SynNotch-CAR T cells demonstrate potent anti-tumor efficacy in a preclinical immunocompetent mouse model for glioblastoma von Lakshmanachetty, Senthilnath, Simic, Milos, Watchmaker, Payal, Yamamichi, Akane, Chen, Tiffany, Phyu, Su, Nejo, Takahide, Shepherd, Chanelle, Duecker, Jason, Wang, Yuan, Troyanskaya, Olga, Cardarelli, Lia, Sidhu, Sachdev, Lim, Wendell, Okada, Hideho

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