Coumarin Metabolism, Toxicity and Carcinogenicity: Relevance for Human Risk Assessment von Lake, B.G

Volltext

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation von Lake, B. G.

Volltext

Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices von Meredith, C., Scott, M. P., Renwick, A. B., Price, R. J., Lake, B. G.

Volltext

Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase von Lake, B. G., Ball, S. E., Kao, J., Renwick, A. B., Price, R. J., Scatina, J. A.

Volltext

A Cancer Risk Assessment of Di(2-ethylhexyl)phthalate: Application of the New U.S. EPA Risk Assessment Guidelines von Doull, John, Cattley, Russell, Elcombe, Cliff, Lake, Brian G., Swenberg, James, Wilkinson, Christopher, Williams, Gary, van Gemert, Marcia

Volltext

Evolution of the cytochrome P450 superfamily: sequence alignments and pharmacogenetics von Lewis, D.F.V., Watson, E., Lake, B.G.

Volltext

Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals von Lake, B G

Volltext

Induction of drug metabolism: Species differences and toxicological relevance von Graham, Mark J, Lake, Brian G

Volltext

Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes von Price, R. J., Scott, M. P., Giddings, A. M., Walters, D. G., Stierum, R. H., Meredith, C., Lake, B. G.

Volltext

Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices von Renwick, A. B., Ball, S. E., Tredger, J. M., Price, R. J., Walters, D. G., Kao, J., Scatina, J. A., Lake, B. G.

Volltext

Quantitative structure–activity relationships for inducers of cytochromes P450 and nuclear receptor ligands involved in P450 regulation within the CYP1, CYP2, CYP3 and CYP4 familie... von Lewis, D.F.V., Jacobs, M.N., Dickins, M., Lake, B.G.

Volltext

Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme–substrate and enzyme–inhibitor interactions von Lewis, D.F.V, Lake, B.G, Bird, M.G, Loizou, G.D, Dickins, M, Goldfarb, P.S

Volltext

Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster von Lake, B.G, Evans, J.G, Chapuis, F, Walters, D.G, Price, R.J

Volltext

Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans? von Cattley, Russell C., DeLuca, John, Elcombe, Cliff, Fenner-Crisp, Penelope, Lake, Brian G., Marsman, Daniel S., Pastoor, Timothy A., Popp, James A., Robinson, Denise E., Schwetz, Bernard, Tugwood, Jonathan, Wahli, Walter

Volltext

Homology modelling of human CYP1A2 based on the CYP2C5 crystallographic template structure von Lewis, D. F. V., Lake, B. G., Dickins, M., Ueng, Y.-F., Goldfarb, P. S.

Volltext

Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver von Lake, Brian G., Renwick, Anthony B., Cunninghame, Morag E., Price, Roger J., Surry, Dominic, Evans, David C.

Volltext

Homology modelling of CYP2A6 based on the CYP2C5 crystallographic template: enzyme–substrate interactions and QSARs for binding affinity and inhibition von Lewis, D.F.V., Lake, B.G., Dickins, M., Goldfarb, P.S.

Volltext

Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems von Pelkonen, O., Myllynen, P., Taavitsainen, P., Boobis, A. R., Watts, P., Lake, B. G., Price, R. J., Renwick, A. B., Gómez-Lechón, M.-J., Castell, J. V., Ingelman-Sundberg, M., Hidestrand, M., Guillouzo, A., Corcos, L., Goldfarb, P. S., Lewis, D. F. V.

Volltext

Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site... von LEWIS, D. F. V, BIRD, M. G, DICKINS, M, LAKE, B. G, EDDERSHAW, P. J, TARBIT, M. H, GOLDFARB, P. S

Volltext

Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms von RENWICK, A. B., MISTRY, H., BALL, S. E., WALTERS, D. G., KAO, J., LAKE, B. G.

Volltext