Pharmacological characterization of GSK573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases von Salmon, Michael, Luttmann, Mark A, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Burman, Miriam, Webb, Edward F, DeHaas, Christopher J, Kotzer, Charles J, Barrett, Victoria J, Slack, Robert J, Sarau, Henry M, Palovich, Michael R, Lainé, Dramane I, Hay, Douglas W P, Rumsey, William L

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Discovery of Biphenyl Piperazines as Novel and Long Acting Muscarinic Acetylcholine Receptor Antagonists von Jin, Jian, Budzik, Brian, Wang, Yonghui, Shi, Dongchuan, Wang, Feng, Xie, Haibo, Wan, Zehong, Zhu, Chongye, Foley, James J, Webb, Edward F, Berlanga, Manuela, Burman, Miriam, Sarau, Henry M, Morrow, Dwight M, Moore, Michael L, Rivero, Ralph A, Palovich, Michael, Salmon, Michael, Belmonte, Kristen E, Lainé, Dramane I

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Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists von Lainé, Dramane I, McCleland, Brent, Thomas, Sonia, Neipp, Christopher, Underwood, Brian, Dufour, Jeremy, Widdowson, Katherine L, Palovich, Michael R, Blaney, Frank E, Foley, James J, Webb, Edward F, Luttmann, Mark A, Burman, Miriam, Belmonte, Kristen, Salmon, Michael

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Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists von Lainé, Dramane I, Wan, Zehong, Yan, Hongxing, Zhu, Chongjie, Xie, Haibo, Fu, Wei, Busch-Petersen, Jakob, Neipp, Christopher, Davis, Roderick, Widdowson, Katherine L, Blaney, Frank E, Foley, James, Bacon, Alicia M, Webb, Edward F, Luttmann, Mark A, Burman, Miriam, Sarau, Henry M, Salmon, Michael, Palovich, Michael R, Belmonte, Kristen

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Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists von Lainé, Dramane I., Yan, Hongxing, Xie, Haibo, Davis, Roderick S., Dufour, Jeremy, Widdowson, Katherine L., Palovich, Michael R., Wan, Zehong, Foley, James J., Schmidt, Dulcie B., Hunsberger, Gerald E., Burman, Miriam, Bacon, Alicia M., Webb, Edward F., Luttmann, Mark A., Salmon, Michael, Sarau, Henry M., Umbrecht, Sandra T., Landis, Philip S., Peck, Brian J., Busch-Petersen, Jakob

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Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols von Adderley, Nicola J., Buchanan, David J., Dixon, Darren J., Lainé, Dramane I.

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Synthesis of the non-adjacent bis-THF core of cis-sylvaticin using a double oxidative cyclisation von Bhunnoo, Riaz A, Hobbs, Heather, Lainé, Dramane I, Light, Mark E, Brown, Richard C D

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Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists von Lainé, Dramane I., Xie, Haibo, Buffet, Noémie, Foley, James J., Buckley, Peter, Webb, Edward F., Widdowson, Katherine L., Palovich, Michael R., Belmonte, Kristen E.

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An Asymmetric Phase-Transfer Dihydroxylation Reaction von Bhunnoo, Riaz A., Hu, Yulai, Lainé, Dramane I., Brown, Richard C. D.

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Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for th... von Wan, Zehong, Laine, Dramane I., Yan, Hongxing, Zhu, Chongjie, Widdowson, Katherine L., Buckley, Peter T., Burman, Miriam, Foley, James J., Sarau, Henry M., Schmidt, Dulcie B., Webb, Edward F., Belmonte, Kristen E., Palovich, Michael

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M3 muscarinic acetylcholine receptor antagonists : SAR and optimization of bi-aryl amines von BUDZIK, Brian, YONGHUI WANG, SARAU, Henry M, MORROW, Dwight M, MOORE, Michael L, RIVERO, Ralph A, PALOVICH, Michael, SALMON, Michael, BELMONTE, Kristen E, LAINE, Dramane I, JIAN JIN, DONGCHUAN SHI, FENG WANG, HAIBO XIE, ZEHONG WAN, CHONGYE ZHU, FOLEY, James J, NUTHULAGANTI, Parvathi, KALLAL, Lorena A

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Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity von Angell, Richard, Aston, Nicola M., Bamborough, Paul, Buckton, Jacky B., Cockerill, Stuart, deBoeck, Suzanne J., Edwards, Chris D., Holmes, Duncan S., Jones, Katherine L., Laine, Dramane I., Patel, Shila, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L.

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Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes von Angell, Richard M., Angell, Tony D., Bamborough, Paul, Bamford, Mark J., Chung, Chun-wa, Cockerill, Stuart G., Flack, Stephen S., Jones, Katherine L., Laine, Dramane I., Longstaff, Timothy, Ludbrook, Steve, Pearson, Rosannah, Smith, Kathryn J., Smee, Penny A., Somers, Don O., Walker, Ann L.

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Interim Analysis of a Phase 2 Trial to Assess the Efficacy and Safety of Crizanlizumab in Sickle Cell Disease Patients with Priapism (SPARTAN) von Anderson, Alan, El Rassi, Fuad, DeBaun, Michael R., Idowu, Modupe, Kanter, Julie, Adam, Soheir, Curtis, Susanna, Liles, Darla, Andemariam, Biree, McLemore, Morgan L., Nickel, Robert Sheppard, Ramadas, Poornima, Paulose, Jincy, Laine, Dramane I, Khan, Mahmudul, Darbari, Deepika S., Burnett, Arthur L.

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A Prospective Phase II, Open-Label, Single-Arm, Multicenter Study to Assess the Efficacy and Safety of SEG101 (Crizanlizumab) in Sickle Cell Disease Patients with Priapism (SPARTAN... von El Rassi, Fuad A, Darbari, Deepika S., Burnett, Arthur, Paulose, Jincy, Laine, Dramane I, Purkayastha, Das, Kato, Gregory J

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Short asymmetric syntheses of bioactive β-aryl ethanolamine derivatives via the highly diastereoselective delta lactol oxy-Michael addition von Buchanan, David J., Dixon, Darren J., Scott, Mark S., Lainé, Dramane I.

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Highly Diastereoselective Oxy-Michael Additions of Enantiopure δ-Lactol Anions to Nitroalkenes: Asymmetric Synthesis of 1,2-Amino Alcohols von Adderley, Nicola J., Buchanan, David J., Dixon, Darren J., Lainé, Dramane I.

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Discovery of Novel l-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists von LAINE, Dramane I, MCCLELAND, Brent, WEBB, Edward F, LUTTMANN, Mark A, BURMAN, Miriam, BELMONTE, Kristen, SALMON, Michael, THOMAS, Sonia, NEIPP, Christopher, UNDERWOOD, Brian, DUFOUR, Jeremy, WIDDOWSON, Katherine L, PALOVICH, Michael R, BLANEY, Frank E, FOLEY, James J

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Discovery of (3-endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicycl o[3.2 .1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for t... von Wan, Zehong, Laine, Dramane I, Yan, Hongxing, Zhu, Chongjie, Widdowson, Katherine L, Buckley, Peter T, Burman, Miriam, Foley, James J, Sarau, Henry M, Schmidt, Dulcie B, Webb, Edward F, Belmonte, Kristen E, Palovich, Michael

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An Asymmetric Phase-Transfer Dihydroxylation Reaction von Bhunnoo, Riaz A., Hu, Yulai, Lainé, Dramane I., Brown, Richard C. D.

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